# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 15 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150319: Eukaryota_PTN000331679 has function glucosamine 6-phosphate N-acetyltransferase activity (GO:0004343) # cellular_component # biological_process 20150320: Eukaryota_PTN000331679 participates in UDP-N-acetylglucosamine biosynthetic process (GO:0006048) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES MF: based on pmids:11278591, 18675810 and 16408321 and their lists of important residues for binding/activity, Viridiplantae_PTN000331750 lost important residues; the eubacterial_PTN001000786 and PTN001411007 also lost important residues and more divergent - these groups were excluded from propagation CC: according to pmid:16408321 members of the Leloir pathway are all cytoplasmic. The few experrimental annotations say, the enzyme is membrane associated along the secretory pathway => unsure what to do BP: based on the MF note, propagation of "UDP-N-acetylglucosamine biosynthetic process" seemed warranted # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).