# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 15 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150728: Eukaryota_PTN000288208 has function ubiquitin-protein transferase activity (GO:0004842) # cellular_component 20150728: Eukaryota_PTN000288208 is found in CCR4-NOT complex (GO:0030014) # biological_process # PRUNED 25 Mar 2016: Embryophyta_PTN000972435 has been pruned from tree # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES 15 Mar 2016: Embryophyta_PTN000972435 has been pruned from tree Review PMIFD:22027279 NOT4 may not be a stable component of the CCR4-NOT complex. Its role in transcirptional elongation is not clear, so did not propagate the annotation. PG 2015-07-28 # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).