# HISTORY 25 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20151125: root_PTN000213391 has function symporter activity (GO:0015293) 20151125: Bacteria _PTN000213736 has function glycolate transmembrane transporter activity (GO:0043879) 20151125: Bacteria _PTN000213736 has function acetate transmembrane transporter activity (GO:0015123) 20151125: Eukaryota_PTN001371444 has function spermidine transmembrane transporter activity (GO:0015606) 20151125: Eukaryota_PTN001721680 has function choline binding (GO:0033265) 20151125: Eukaryota_PTN001721680 has function choline:sodium symporter activity (GO:0005307) 20151125: Bacteria _PTN000929722 has function pantothenate transmembrane transporter activity (GO:0015233) 20151125: Bacteria _PTN001371338 has function proline:sodium symporter activity (GO:0005298) 20151125: Chordata_PTN001371381 has function glucose:sodium symporter activity (GO:0005412) 20151125: Chordata_PTN001721754 has function low-affinity glucose:sodium symporter activity (GO:0005362) 20151125: Chordata_PTN000213779 has function myo-inositol:sodium symporter activity (GO:0005367) 20151125: Ascomycota_PTN000213709 has function spermidine transmembrane transporter activity (GO:0015606) 20151125: Ascomycota_PTN000213709 has function urea transmembrane transporter activity (GO:0015204) 20151125: Ascomycota_PTN000213709 has function putrescine transmembrane transporter activity (GO:0015489) 20151125: Deuterostomia_PTN000213617 has function sodium-dependent multivitamin transmembrane transporter activity (GO:0008523) 20151125: Chordata_PTN001721832 has function lactate transmembrane transporter activity (GO:0015129) 20151125: Chordata_PTN001721832 has function secondary active monocarboxylate transmembrane transporter activity (GO:0015355) 20151125: Euteleostomi_PTN000213541 has function iodide transmembrane transporter activity (GO:0015111) 20151125: Euteleostomi_PTN000213541 has function sodium:iodide symporter activity (GO:0008507) 20151125: Viridiplantae_PTN000213725 has function urea transmembrane transporter activity (GO:0015204) # cellular_component 20151125: root_PTN000213391 is found in integral component of plasma membrane (GO:0005887) 20151125: Tetrapoda_PTN000213403 is found in synapse (GO:0045202) 20151125: Tetrapoda_PTN000213403 is found in perikaryon (GO:0043204) 20151125: Tetrapoda_PTN000213403 is found in axon (GO:0030424) 20151125: Tetrapoda_PTN000213403 is found in dendrite (GO:0030425) # biological_process 20151125: Bacteria _PTN000213736 participates in plasma membrane acetate transport (GO:0006847) 20151125: Eukaryota_PTN001371444 participates in spermidine transmembrane transport (GO:1903711) 20151125: Eukaryota_PTN001721680 participates in acetylcholine biosynthetic process (GO:0008292) 20151125: Eukaryota_PTN001721680 participates in choline transport (GO:0015871) 20151125: Tetrapoda_PTN000213403 participates in neuromuscular synaptic transmission (GO:0007274) 20151125: Tetrapoda_PTN000213403 participates in synaptic transmission, cholinergic (GO:0007271) 20151125: Bacteria _PTN001371338 participates in proline transmembrane transport (GO:0035524) 20151125: Chordata_PTN001371381 participates in sodium ion transport (GO:0006814) 20151125: Chordata_PTN001371381 participates in glucose transmembrane transport (GO:1904659) 20151125: Theria _PTN000929918 participates in intestinal D-glucose absorption (GO:0001951) 20151125: Chordata_PTN000213779 participates in inositol metabolic process (GO:0006020) 20151125: Chordata_PTN000213779 participates in myo-inositol transport (GO:0015798) 20151125: Ascomycota_PTN000213709 participates in spermidine transport (GO:0015848) 20151125: Deuterostomia_PTN000213617 participates in biotin transport (GO:0015878) 20151125: Deuterostomia_PTN000213617 participates in pantothenate transmembrane transport (GO:0015887) 20151125: Euteleostomi_PTN000213541 participates in thyroid hormone generation (GO:0006590) 20151125: Euteleostomi_PTN000213541 participates in iodide transport (GO:0015705) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).