# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.14 07 May 2016: Updated by: TOUCHUP-v1.18 # molecular_function 20150327: root_PTN000184222 has function transmembrane transporter activity (GO:0022857) 20150327: Ascomycota_PTN000185192 has function biotin transmembrane transporter activity (GO:1901603) 20150327: Dikarya_PTN000910851 has function pantothenate transmembrane transporter activity (GO:0015233) 20150327: Ascomycota_PTN000185019 has function cysteine transmembrane transporter activity (GO:0033229) 20150327: saccharomyceta_PTN000910970 has function dipeptide transporter activity (GO:0042936) 20150327: saccharomyceta_PTN000910970 has function allantoate transmembrane transporter activity (GO:0015124) 20150327: Theria _PTN000184401 has function sodium-dependent phosphate transmembrane transporter activity (GO:0015321) 20150327: Theria _PTN000184401 has function sodium:phosphate symporter activity (GO:0005436) 20150327: Euteleostomi_PTN000184256 has function L-glutamate transmembrane transporter activity (GO:0005313) 20150327: Euteleostomi_PTN000184279 has function L-glutamate transmembrane transporter activity (GO:0005313) 20150327: Euteleostomi_PTN000184311 has function sodium:inorganic phosphate symporter activity (GO:0015319) 20150327: Euteleostomi_PTN000184311 has function sodium-dependent phosphate transmembrane transporter activity (GO:0015321) 20150327: Mammalia_PTN000184465 has function sialic acid transmembrane transporter activity (GO:0015136) 20150327: node_PTN000184754 has function inorganic phosphate transmembrane transporter activity (GO:0005315) 20150327: Dikarya_PTN001160829 has function nitrite uptake transmembrane transporter activity (GO:0015513) 20150327: Dikarya_PTN001160829 has function nitrate transmembrane transporter activity (GO:0015112) # cellular_component 20150327: root_PTN000184222 is found in integral component of membrane (GO:0016021) 20150327: Ascomycota_PTN000185192 is found in integral component of plasma membrane (GO:0005887) 20150327: Dikarya_PTN000910851 is found in plasma membrane (GO:0005886) 20150327: saccharomyceta_PTN000910970 is found in plasma membrane (GO:0005886) 20150327: Chordata_PTN001361938 is found in integral component of plasma membrane (GO:0005887) 20150327: Bilateria_PTN000184252 is found in synaptic vesicle membrane (GO:0030672) 20150327: Mammalia_PTN000184465 is found in lysosome (GO:0005764) 20150327: Pancrustacea_PTN000910672 is found in plasma membrane (GO:0005886) 20150327: node_PTN000184754 is found in plastid (GO:0009536) # biological_process 20150327: root_PTN000184222 participates in anion transport (GO:0006820) 20150327: root_PTN000184222 participates in transmembrane transport (GO:0055085) 20150327: Ascomycota_PTN000185192 participates in vitamin transmembrane transport (GO:0035461) 20150327: Ascomycota_PTN000185192 participates in biotin import into cell (GO:0044756) 20150327: Dikarya_PTN000910851 participates in pantothenate import into cell (GO:0044755) 20150327: Ascomycota_PTN000185019 participates in cysteine transport (GO:0042883) 20150327: saccharomyceta_PTN000910970 participates in dipeptide transport (GO:0042938) 20150327: saccharomyceta_PTN000910970 participates in tripeptide transport (GO:0042939) 20150327: Theria _PTN000184401 participates in sodium ion transmembrane transport (GO:0035725) 20150327: Euteleostomi_PTN000184279 participates in L-glutamate transmembrane transport (GO:0089711) 20150327: Euteleostomi_PTN000184311 participates in sodium ion transmembrane transport (GO:0035725) 20150327: Mammalia_PTN000184465 participates in sialic acid transport (GO:0015739) 20150327: node_PTN000184754 participates in anion transmembrane transport (GO:0098656) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).