# HISTORY 24 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20140813: Eumetazoa_PTN000908679 has function growth factor receptor binding (GO:0070851) 20130404: node_PTN000180420 has function platelet-derived growth factor receptor binding (GO:0005161) # cellular_component 20130404: Eumetazoa_PTN000908679 is found in extracellular space (GO:0005615) # biological_process 20130404: Eumetazoa_PTN000908679 participates in positive regulation of protein autophosphorylation (GO:0031954) 20130404: Eumetazoa_PTN000908679 participates in positive regulation of cell proliferation (GO:0008284) 20130404: node_PTN000180420 participates in positive regulation of phosphatidylinositol 3-kinase signaling (GO:0014068) 20130404: node_PTN000180420 participates in positive regulation of cell migration (GO:0030335) 20130404: node_PTN000180420 participates in blood coagulation (GO:0007596) 20130404: node_PTN000180420 participates in positive regulation of MAP kinase activity (GO:0043406) 20130404: node_PTN000180420 participates in positive regulation of ERK1 and ERK2 cascade (GO:0070374) 20130404: node_PTN000180420 participates in platelet-derived growth factor receptor signaling pathway (GO:0048008) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES PG Review annotations 2014-08-13 # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).