# HISTORY
24 Mar 2016: Updated by: TOUCHUP-v1.15
14 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20140725: node_PTN000150424 has function ornithine carbamoyltransferase activity (GO:0004585) 
20140725: node_PTN000150382 contributes to function carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity (GO:0004088) 
20140725: node_PTN000150223 has function carbamoyl-phosphate synthase (ammonia) activity (GO:0004087) 
20140725: node_PTN000150223 has function carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity (GO:0004088) 
20140725: Eukaryota_PTN000150226 has function dihydroorotase activity (GO:0004151) 
20140725: Eukaryota_PTN000150226 has function aspartate carbamoyltransferase activity (GO:0004070) 
20140725: node_PTN000150350 has function aspartate carbamoyltransferase activity (GO:0004070) 
20140725: Dikarya_PTN000892150 has LOST/MODIFIED function dihydroorotase activity (GO:0004151) 
20140725: Dikarya_PTN000892150 has LOST/MODIFIED function aspartate carbamoyltransferase activity (GO:0004070) 

# cellular_component
20140725: root_PTN000150222 is found in cytoplasm (GO:0005737) 
20140725: Eukaryota_PTN000150426 is found in intracellular membrane-bounded organelle (GO:0043231) 
20140725: Opisthokonta_PTN000150427 is found in mitochondrion (GO:0005739) 
20140725: node_PTN000150382 is found in carbamoyl-phosphate synthase complex (GO:0005951) 

# biological_process
20140725: root_PTN000150222 participates in urea cycle (GO:0000050) 
20140725: root_PTN000150222 participates in primary metabolic process (GO:0044238) 
20140725: node_PTN000150424 participates in arginine biosynthetic process via ornithine (GO:0042450) 
20140725: node_PTN000150382 participates in arginine biosynthetic process (GO:0006526) 
20140725: node_PTN000150223 participates in arginine biosynthetic process (GO:0006526) 
20140725: Eukaryota_PTN000150226 participates in 'de novo' pyrimidine nucleobase biosynthetic process (GO:0006207) 
20140725: node_PTN000150350 participates in pyrimidine ribonucleotide biosynthetic process (GO:0009220) 
# PRUNED
20140725: node_PTN000150350 does NOT participate in urea cycle (GO:0000050) 

24 Mar 2016: node_PTN000892177 has been pruned from tree
24 Mar 2016: node_PTN000892110 has been pruned from tree

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
14 Mar 2016: node_PTN000892177 has been pruned from tree
14 Mar 2016: node_PTN000892110 has been pruned from tree
Tree:
- The phylogeny of this family is not clear because it contains gene fusions and truncations (for eg S. cerevisiae CPA1).
- PTN000892126 (A. thaliana PYRB) should probably in another tree.
- Node containing E. coli ArgF should probably in the same subsamily as Human OTC and yeast ARG3.
Yeast URA2
- Has an inactive DHO domain, see PMID:2570735.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).