definition expand assertion to term replaced by Class: ?X DisjointWith: RO_0002162 some ?Y RO:0002161 external never_in_taxon true true never_in_taxon never_in_taxon Term not to be used for direct annotation Term not to be used for direct manual annotation AGR slim Aspergillus GO slim Candida GO slim ChEMBL protein targets summary Generic GO slim Metagenomics GO slim Mouse GO slim PIR GO slim Plant GO slim Fission yeast GO slim synapse GO slim Yeast GO slim label approved by the SynGO project Systematic synonym subset_property synonym_type_property consider has_alternative_id has_broad_synonym database_cross_reference has_exact_synonym has_narrow_synonym has_obo_format_version has_obo_namespace has_related_synonym has_scope has_synonym_type in_subset shorthand BFO:0000050 external part_of part_of part of BFO:0000051 external has_part has_part has_part BFO:0000066 external occurs_in occurs_in occurs in RO:0002091 external starts_during starts_during starts_during RO:0002092 external happens_during happens_during happens_during RO:0002093 external ends_during ends_during ends_during RO:0002211 external regulates regulates regulates RO:0002212 external negatively_regulates negatively_regulates negatively regulates RO:0002213 external positively_regulates positively_regulates positively regulates The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. neurotransmitter recycling Reactome:REACT_106095 Reactome:REACT_106673 Reactome:REACT_107830 Reactome:REACT_114027 Reactome:REACT_13594 Reactome:REACT_29399 Reactome:REACT_30311 Reactome:REACT_82534 Reactome:REACT_88126 Reactome:REACT_89424 Reactome:REACT_92363 Reactome:REACT_93291 Reactome:REACT_94616 Reactome:REACT_97761 Reactome:REACT_98224 Reactome:REACT_98482 Reactome:REACT_98978 Reactome:REACT_99735 neurotransmitter import neurotransmitter import into glial cell neurotransmitter import into neuron biological_process GO:0001504 neurotransmitter uptake The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. ISBN:0123668387 Reactome:REACT_106095 Neurotransmitter uptake and Metabolism In Glial Cells, Gallus gallus Reactome:REACT_106673 Neurotransmitter uptake and Metabolism In Glial Cells, Bos taurus Reactome:REACT_107830 Neurotransmitter uptake and Metabolism In Glial Cells, Arabidopsis thaliana Reactome:REACT_114027 Neurotransmitter uptake and Metabolism In Glial Cells, Staphylococcus aureus N315 Reactome:REACT_13594 Neurotransmitter uptake and Metabolism In Glial Cells, Homo sapiens Reactome:REACT_29399 Neurotransmitter uptake and Metabolism In Glial Cells, Drosophila melanogaster Reactome:REACT_30311 Neurotransmitter uptake and Metabolism In Glial Cells, Rattus norvegicus Reactome:REACT_82534 Neurotransmitter uptake and Metabolism In Glial Cells, Caenorhabditis elegans Reactome:REACT_88126 Neurotransmitter uptake and Metabolism In Glial Cells, Escherichia coli Reactome:REACT_89424 Neurotransmitter uptake and Metabolism In Glial Cells, Sus scrofa Reactome:REACT_92363 Neurotransmitter uptake and Metabolism In Glial Cells, Canis familiaris Reactome:REACT_93291 Neurotransmitter uptake and Metabolism In Glial Cells, Taeniopygia guttata Reactome:REACT_94616 Neurotransmitter uptake and Metabolism In Glial Cells, Schizosaccharomyces pombe Reactome:REACT_97761 Neurotransmitter uptake and Metabolism In Glial Cells, Saccharomyces cerevisiae Reactome:REACT_98224 Neurotransmitter uptake and Metabolism In Glial Cells, Oryza sativa Reactome:REACT_98482 Neurotransmitter uptake and Metabolism In Glial Cells, Xenopus tropicalis Reactome:REACT_98978 Neurotransmitter uptake and Metabolism In Glial Cells, Danio rerio Reactome:REACT_99735 Neurotransmitter uptake and Metabolism In Glial Cells, Mus musculus neurotransmitter import GOC:dph GOC:tb The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. signal transmission across a synapse synaptic transmission Reactome:REACT_102443 Reactome:REACT_102748 Reactome:REACT_102963 Reactome:REACT_104470 Reactome:REACT_104894 Reactome:REACT_105301 Reactome:REACT_106168 Reactome:REACT_106459 Reactome:REACT_107151 Reactome:REACT_107221 Reactome:REACT_112265 Reactome:REACT_113444 Reactome:REACT_13477 Reactome:REACT_13685 Reactome:REACT_29254 Reactome:REACT_29595 Reactome:REACT_29683 Reactome:REACT_30050 Reactome:REACT_30266 Reactome:REACT_31284 Reactome:REACT_33322 Reactome:REACT_33434 Reactome:REACT_78038 Reactome:REACT_78840 Reactome:REACT_79078 Reactome:REACT_80052 Reactome:REACT_82334 Reactome:REACT_82746 Reactome:REACT_86563 Reactome:REACT_86628 Reactome:REACT_88599 Reactome:REACT_88891 Reactome:REACT_89065 Reactome:REACT_89149 Reactome:REACT_89785 Reactome:REACT_90781 Reactome:REACT_93592 Reactome:REACT_98546 Reactome:REACT_99535 Reactome:REACT_99952 Wikipedia:Neurotransmission biological_process neurotransmission GO:0007268 chemical synaptic transmission The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. GOC:jl MeSH:D009435 Reactome:REACT_102443 Transmission across Chemical Synapses, Mycobacterium tuberculosis Reactome:REACT_102748 Neuronal System, Saccharomyces cerevisiae Reactome:REACT_102963 Transmission across Chemical Synapses, Canis familiaris Reactome:REACT_104470 Transmission across Chemical Synapses, Rattus norvegicus Reactome:REACT_104894 Neuronal System, Xenopus tropicalis Reactome:REACT_105301 Transmission across Chemical Synapses, Caenorhabditis elegans Reactome:REACT_106168 Transmission across Chemical Synapses, Escherichia coli Reactome:REACT_106459 Transmission across Chemical Synapses, Mus musculus Reactome:REACT_107151 Neuronal System, Sus scrofa Reactome:REACT_107221 Transmission across Chemical Synapses, Schizosaccharomyces pombe Reactome:REACT_112265 Transmission across Chemical Synapses, Staphylococcus aureus N315 Reactome:REACT_113444 Neuronal System, Staphylococcus aureus N315 Reactome:REACT_13477 Transmission across Chemical Synapses, Homo sapiens Reactome:REACT_13685 Neuronal System, Homo sapiens Reactome:REACT_29254 Neuronal System, Danio rerio Reactome:REACT_29595 Neuronal System, Caenorhabditis elegans Reactome:REACT_29683 Transmission across Chemical Synapses, Drosophila melanogaster Reactome:REACT_30050 Transmission across Chemical Synapses, Gallus gallus Reactome:REACT_30266 Transmission across Chemical Synapses, Sus scrofa Reactome:REACT_31284 Transmission across Chemical Synapses, Saccharomyces cerevisiae Reactome:REACT_33322 Neuronal System, Taeniopygia guttata Reactome:REACT_33434 Neuronal System, Escherichia coli Reactome:REACT_78038 Neuronal System, Rattus norvegicus Reactome:REACT_78840 Transmission across Chemical Synapses, Taeniopygia guttata Reactome:REACT_79078 Transmission across Chemical Synapses, Arabidopsis thaliana Reactome:REACT_80052 Neuronal System, Schizosaccharomyces pombe Reactome:REACT_82334 Transmission across Chemical Synapses, Bos taurus Reactome:REACT_82746 Neuronal System, Arabidopsis thaliana Reactome:REACT_86563 Neuronal System, Mus musculus Reactome:REACT_86628 Neuronal System, Canis familiaris Reactome:REACT_88599 Neuronal System, Bos taurus Reactome:REACT_88891 Neuronal System, Mycobacterium tuberculosis Reactome:REACT_89065 Neuronal System, Gallus gallus Reactome:REACT_89149 Neuronal System, Dictyostelium discoideum Reactome:REACT_89785 Neuronal System, Drosophila melanogaster Reactome:REACT_90781 Transmission across Chemical Synapses, Danio rerio Reactome:REACT_93592 Transmission across Chemical Synapses, Xenopus tropicalis Reactome:REACT_98546 Transmission across Chemical Synapses, Dictyostelium discoideum Reactome:REACT_99535 Transmission across Chemical Synapses, Oryza sativa Reactome:REACT_99952 Neuronal System, Oryza sativa neurotransmission GOC:dph The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission. GO:0010554 Reactome:REACT_100716 Reactome:REACT_102134 Reactome:REACT_102586 Reactome:REACT_102743 Reactome:REACT_105010 Reactome:REACT_105885 Reactome:REACT_110862 Reactome:REACT_11184 Reactome:REACT_113329 Reactome:REACT_115061 Reactome:REACT_13723 Reactome:REACT_29477 Reactome:REACT_29495 Reactome:REACT_29928 Reactome:REACT_77375 Reactome:REACT_85993 Reactome:REACT_91316 Reactome:REACT_95406 Reactome:REACT_99398 neurotransmitter release neurotransmitter secretory pathway biological_process GO:0007269 A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin. neurotransmitter secretion The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission. CHEBI:25512 GOC:dph Reactome:REACT_100716 Neurotransmitter Release Cycle, Bos taurus Reactome:REACT_102134 Neurotransmitter Release Cycle, Arabidopsis thaliana Reactome:REACT_102586 Neurotransmitter Release Cycle, Xenopus tropicalis Reactome:REACT_102743 Neurotransmitter Release Cycle, Rattus norvegicus Reactome:REACT_105010 Neurotransmitter Release Cycle, Oryza sativa Reactome:REACT_105885 Neurotransmitter Release Cycle, Taeniopygia guttata Reactome:REACT_110862 Neurotransmitter Release Cycle, Sus scrofa Reactome:REACT_11184 Botulinum neurotoxicity, Homo sapiens Reactome:REACT_113329 Neurotransmitter Release Cycle, Staphylococcus aureus N315 Reactome:REACT_115061 Neurotransmitter Release Cycle, Dictyostelium discoideum Reactome:REACT_13723 Neurotransmitter Release Cycle, Homo sapiens Reactome:REACT_29477 Neurotransmitter Release Cycle, Danio rerio Reactome:REACT_29495 Neurotransmitter Release Cycle, Drosophila melanogaster Reactome:REACT_29928 Neurotransmitter Release Cycle, Mus musculus Reactome:REACT_77375 Neurotransmitter Release Cycle, Mycobacterium tuberculosis Reactome:REACT_85993 Neurotransmitter Release Cycle, Canis familiaris Reactome:REACT_91316 Neurotransmitter Release Cycle, Caenorhabditis elegans Reactome:REACT_95406 Neurotransmitter Release Cycle, Gallus gallus Reactome:REACT_99398 Neurotransmitter Release Cycle, Escherichia coli The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional). Wikipedia:Synaptogenesis synapse biogenesis synaptogenesis biological_process GO:0007416 synapse assembly The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional). GOC:mah synapse biogenesis GOC:mah synaptogenesis GOC:mah A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. NIF_Subcellular:sao1071221672 Wikipedia:Synaptic_vesicle docked vesicle cellular_component GO:0008021 This term should not be confused with GO:0097547 'synaptic vesicle protein transport vesicle'. STVs and synaptic vesicles differ both functionally and morphologically. Functionally, STVs are transport vesicles that deliver synaptic vesicle proteins to synapses, while synaptic vesicles are responsible for transmitter release at synapses. Morphologically, synaptic vesicles are very homogeneous, while STVs are very heterogeneous in size and shape. STVs might be a precursor for synaptic vesicles. synaptic vesicle A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane. PMID:10099709 PMID:12563290 docked vesicle NIF_Subcellular:sao403156667 The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses. neuronal targeting biological_process GO:0008039 synaptic target recognition The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses. GOC:mah ISBN:0878932437 The directed movement of organelles or molecules along microtubules in neuron projections. Wikipedia:Axoplasmic_transport axon cargo transport axonal transport axoplasmic transport biological_process GO:0008088 axo-dendritic transport The directed movement of organelles or molecules along microtubules in neuron projections. ISBN:0815316194 The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons. anterograde axon cargo transport biological_process GO:0008089 anterograde axonal transport The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons. ISBN:0815316194 The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons. retrograde axon cargo transport biological_process GO:0008090 retrograde axonal transport The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons. ISBN:0815316194 Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion. biological_process GO:0010807 regulation of synaptic vesicle priming Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion. GOC:dph GOC:kmv GOC:tb PMID:15489511 An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. paola 2013-07-02T09:44:28Z GO:0097481 GO:0097483 NIF_Subcellular:sao1196688972 Wikipedia:Postsynaptic_density neuronal postsynaptic density post synaptic density post-synaptic density postsynaptic density of dendrite cellular_component GO:0014069 postsynaptic density An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. GOC:BHF GOC:dos GOC:ef GOC:jid GOC:pr GOC:sjp PMID:14532281 Wikipedia:Postsynaptic_density http://molneuro.kaist.ac.kr/psd neuronal postsynaptic density GO:0097481 Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft. biological_process GO:0016079 synaptic vesicle exocytosis Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft. GOC:jid GOC:lmg The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process. synaptic vesicle docking involved in exocytosis biological_process synaptic vesicle docking during exocytosis GO:0016081 Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission (dos, pvn, fk synapse project 2015). synaptic vesicle docking The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process. PMID:15217342 synaptic vesicle docking during exocytosis GOC:dph GOC:tb A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane. biological_process GO:0016082 Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission. (dos, pvn, fk synapse project 2015) synaptic vesicle priming A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane. GOC:mah PMID:15217342 PMID:23060190 Budding of synaptic vesicles during the formation of constitutive recycling vesicles from early endosomes. synaptic vesicle budding involved in synaptic vesicle exocytosis biological_process endosome to synaptic vesicle budding GO:0016182 synaptic vesicle budding from endosome Budding of synaptic vesicles during the formation of constitutive recycling vesicles from early endosomes. GOC:curators PMID:10099709 PMID:24596248 synaptic vesicle budding involved in synaptic vesicle exocytosis GOC:mah endosome to synaptic vesicle budding GOC:mah The formation of clathrin coated pits in the presynaptic membrane endocytic zone, triggered by the presence of high concentrations of synaptic vesicle components. This process leads to, but does not include budding of the membrane to form new vesicles. biological_process GO:0016183 synaptic vesicle coating The formation of clathrin coated pits in the presynaptic membrane endocytic zone, triggered by the presence of high concentrations of synaptic vesicle components. This process leads to, but does not include budding of the membrane to form new vesicles. GOC:curators PMID:10099709 PMID:20448150 Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle. synaptic vesicle budding from pre-synaptic membrane synaptic vesicle budding involved in synaptic vesicle endocytosis biological_process GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle. GOC:curators PMID:10099709 PMID:20448150 synaptic vesicle budding involved in synaptic vesicle endocytosis GOC:mah Fusion of a synaptic vesicle with an endosome. biological_process GO:0016189 This covers fusion of synaptic vesicles trafficked to the synapse as well as fusion of endocytosed vesicles as part of recycling. It is there for not part of the synaptic vesicle cycle. synaptic vesicle to endosome fusion Fusion of a synaptic vesicle with an endosome. GOC:curators PMID:10099709 The removal of the protein coat on a synaptic vesicle following the pinching step at the end of budding from the presynaptic membrane. synaptic vesicle coat depolymerization synaptic vesicle coat protein depolymerization biological_process GO:0016191 synaptic vesicle uncoating The removal of the protein coat on a synaptic vesicle following the pinching step at the end of budding from the presynaptic membrane. GOC:curators PMID:10099709 PMID:24596248 The directed movement of mitochondria along microtubules in nerve cell axons. axon transport of mitochondria biological_process GO:0019896 axonal transport of mitochondrion The directed movement of mitochondria along microtubules in nerve cell axons. GOC:ai The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. integral to synaptic vesicle membrane cellular_component GO:0030285 integral component of synaptic vesicle membrane The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. GOC:dos GOC:go_curators The lipid bilayer surrounding a synaptic vesicle. cellular_component GO:0030672 synaptic vesicle membrane The lipid bilayer surrounding a synaptic vesicle. GOC:mah Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft. synaptic vesicle fusion synaptic vesicle fusion to pre-synaptic membrane synaptic vesicle fusion to presynaptic membrane biological_process GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft. ISBN:0071120009 Any process that modulates the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane. regulation of synaptic vesicle fusion to pre-synaptic membrane regulation of synaptic vesicle fusion to presynaptic membrane biological_process GO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane Any process that modulates the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane. GOC:mah The volume enclosed by the synaptic vesicle membrane. cellular_component GO:0034592 synaptic vesicle lumen The volume enclosed by the synaptic vesicle membrane. GOC:rph Synaptic vesicle recycling where vesicles endocytose via clathrin-coated pits, re-acidify, and refill with neurotransmitters after passing through an endosomal intermediate. rebeccafoulger 2014-06-26T11:07:46Z GO:0099090 recycling endosome localization within postsynapse biological_process GO:0036466 synaptic vesicle recycling via endosome Synaptic vesicle recycling where vesicles endocytose via clathrin-coated pits, re-acidify, and refill with neurotransmitters after passing through an endosomal intermediate. GOC:PARL GOC:bf GOC:dos GOC:pad PMID:15217342 The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. neurotransmitter breakdown neurotransmitter catabolism neurotransmitter degradation biological_process GO:0042135 neurotransmitter catabolic process The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. CHEBI:25512 GOC:jl The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. neurotransmitter biosynthesis and storage neurotransmitter biosynthetic process and storage Reactome:REACT_101731 Reactome:REACT_107523 Reactome:REACT_108610 Reactome:REACT_108742 Reactome:REACT_110245 Reactome:REACT_112396 Reactome:REACT_115066 Reactome:REACT_13583 Reactome:REACT_28513 Reactome:REACT_77139 Reactome:REACT_81660 Reactome:REACT_82622 Reactome:REACT_83009 Reactome:REACT_89303 Reactome:REACT_93349 Reactome:REACT_99114 Reactome:REACT_99596 Reactome:REACT_99804 neurotransmitter anabolism neurotransmitter biosynthesis neurotransmitter formation neurotransmitter synthesis biological_process GO:0042136 neurotransmitter biosynthetic process The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. CHEBI:25512 GOC:jl Reactome:REACT_101731 Neurotransmitter Clearance In The Synaptic Cleft, Sus scrofa Reactome:REACT_107523 Neurotransmitter Clearance In The Synaptic Cleft, Schizosaccharomyces pombe Reactome:REACT_108610 Neurotransmitter Clearance In The Synaptic Cleft, Mycobacterium tuberculosis Reactome:REACT_108742 Neurotransmitter Clearance In The Synaptic Cleft, Caenorhabditis elegans Reactome:REACT_110245 Neurotransmitter Clearance In The Synaptic Cleft, Xenopus tropicalis Reactome:REACT_112396 Neurotransmitter Clearance In The Synaptic Cleft, Escherichia coli Reactome:REACT_115066 Neurotransmitter Clearance In The Synaptic Cleft, Dictyostelium discoideum Reactome:REACT_13583 Neurotransmitter Clearance In The Synaptic Cleft, Homo sapiens Reactome:REACT_28513 Neurotransmitter Clearance In The Synaptic Cleft, Taeniopygia guttata Reactome:REACT_77139 Neurotransmitter Clearance In The Synaptic Cleft, Rattus norvegicus Reactome:REACT_81660 Neurotransmitter Clearance In The Synaptic Cleft, Arabidopsis thaliana Reactome:REACT_82622 Neurotransmitter Clearance In The Synaptic Cleft, Bos taurus Reactome:REACT_83009 Neurotransmitter Clearance In The Synaptic Cleft, Gallus gallus Reactome:REACT_89303 Neurotransmitter Clearance In The Synaptic Cleft, Oryza sativa Reactome:REACT_93349 Neurotransmitter Clearance In The Synaptic Cleft, Danio rerio Reactome:REACT_99114 Neurotransmitter Clearance In The Synaptic Cleft, Drosophila melanogaster Reactome:REACT_99596 Neurotransmitter Clearance In The Synaptic Cleft, Mus musculus Reactome:REACT_99804 Neurotransmitter Clearance In The Synaptic Cleft, Canis familiaris A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. pre-synaptic membrane presynaptic plasma membrane cellular_component GO:0042734 presynaptic membrane A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. GOC:jl ISBN:0815316194 The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released. NIF_Subcellular:sao243541954 cellular_component GO:0043083 synaptic cleft The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released. GOC:jl http://synapses.mcg.edu/anatomy/chemical/synapse.stm A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including "thin", "stubby", "mushroom", and "branched", with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. NIF_Subcellular:sao1799103720 Wikipedia:Dendritic_spine dendrite spine branched dendritic spine mushroom dendritic spine sessile dendritic spine stubby dendritic spine thin dendritic spine cellular_component GO:0043197 dendritic spine A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including "thin", "stubby", "mushroom", and "branched", with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. GOC:nln branched dendritic spine NIF_Subcellular:sao-965204139 mushroom dendritic spine NIF_Subcellular:sao-876577163 sessile dendritic spine NIF_Subcellular:sao1536532595 stubby dendritic spine NIF_Subcellular:sao317384566 thin dendritic spine NIF_Subcellular:sao1232858786 The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. NIF_Subcellular:sao914572699 Wikipedia:Chemical_synapse synaptic junction mixed synapse cellular_component electrotonic synapse GO:0045202 synapse The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. ISBN:0198506732 mixed synapse NIF_Subcellular:sao1506103497 electrotonic synapse NIF_Subcellular:sao1311109124 A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. post-synaptic membrane cellular_component GO:0045211 postsynaptic membrane A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. ISBN:0198506732 A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms. GO:0008099 biological_process synaptic vesicle retrieval GO:0048488 Changed parent as requested in https://github.com/geneontology/synapse/issues/230 synaptic vesicle endocytosis A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms. GOC:aruk GOC:bc GOC:jid GOC:lmg GOC:mah PMID:20448150 PMID:26430111 The directed movement of synaptic vesicles. GO:0016181 biological_process synaptic vesicle fission synaptic vesicle fusion synaptic vesicle trafficking GO:0048489 synaptic vesicle transport The directed movement of synaptic vesicles. GOC:jid GOC:lmg GOC:pr synaptic vesicle trafficking PMID:15217342 The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse. anterograde axonal transport of synaptic vesicle biological_process GO:0048490 anterograde synaptic vesicle transport The directed movement of synaptic vesicle along axonal microtubules from the cell body to the presynapse. GOC:jid GOC:lmg The directed movement of synaptic vesicle along axonal microtubules from the presynapse to the cell body. retrograde axonal transport of synaptic vesicle biological_process GO:0048491 retrograde synaptic vesicle transport The directed movement of synaptic vesicle along axonal microtubules from the presynapse to the cell body. GOC:jid GOC:lmg PMID:24762653 A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix. NIF_Subcellular:sao792027222 pre-synaptic active zone presynaptic specialization pre-synaptic active zone component cellular_component GO:0048786 presynaptic active zone A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix. GOC:dh GOC:dl GOC:ef GOC:jid GOC:pr PMID:3152289 pre-synaptic active zone component NIF_Subcellular:sao1911631652 The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters. NIF_Subcellular:sao2038461087 active zone plasma membrane active zone pre-synaptic plasma membrane active zone presynaptic plasma membrane pre-synaptic active zone membrane cellular_component GO:0048787 presynaptic active zone membrane The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters. PMID:12812759 PMID:12923177 PMID:3152289 active zone plasma membrane NIF_Subcellular:sao2038461087 A process which maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and docking of vesicles and the release of neurotransmitters. maintenance of pre-synaptic active zone structure biological_process GO:0048790 maintenance of presynaptic active zone structure A process which maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and docking of vesicles and the release of neurotransmitters. GOC:curators GOC:dph GOC:pr Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission. modulation of synaptic transmission regulation of chemical synaptic transmission regulation of synaptic transmission biological_process GO:0050804 modulation of chemical synaptic transmission Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission. GOC:ai Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). regulation of synapse organisation regulation of synapse structure biological_process regulation of synapse organization and biogenesis GO:0050807 regulation of synapse organization Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). GOC:ai GOC:dph GOC:tb regulation of synapse organisation GOC:mah regulation of synapse organization and biogenesis GOC:mah A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). synapse organisation biological_process synapse development synapse morphogenesis synapse organization and biogenesis GO:0050808 synapse organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell). GOC:ai GOC:pr synapse organisation GOC:curators synapse development GOC:aruk synapse morphogenesis GOC:BHF synapse organization and biogenesis GOC:mah Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell. regulation of neurotransmitter import regulation of neurotransmitter reuptake biological_process GO:0051580 regulation of neurotransmitter uptake Any process that modulates the frequency, rate or extent of the directed movement of a neurotransmitter into a neuron or glial cell. GOC:ai regulation of neurotransmitter import GOC:dph GOC:tb Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. regulation of synapse biogenesis regulation of synaptogenesis biological_process GO:0051963 regulation of synapse assembly Any process that modulates the frequency, rate or extent of synapse assembly, the aggregation, arrangement and bonding together of a set of components to form a synapse. GOC:ai GOC:pr The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development. synaptic maturation biological_process GO:0060074 synapse maturation The process that organizes a synapse so that it attains its fully functional state. Synaptic maturation plays a critical role in the establishment of effective synaptic connections in early development. GOC:dph GOC:ef Any process that modulates the potential difference across a post-synaptic membrane. regulation of post-synaptic membrane potential biological_process GO:0060078 regulation of postsynaptic membrane potential Any process that modulates the potential difference across a post-synaptic membrane. GOC:dph GOC:ef Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state. tanyaberardini 2009-12-07T03:00:58Z biological_process GO:0090128 regulation of synapse maturation Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state. GOC:ascb_2009 GOC:dph GOC:tb A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. paola 2011-06-07T11:22:09Z cellular_component GO:0097060 synaptic membrane A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. GOC:BHF PMID:20410104 The process that results in grouping synaptic vesicles in presynaptic structures. paola 2011-07-04T01:48:24Z biological_process GO:0097091 Updated definition as requested by SynGO group, see https://github.com/geneontology/synapse/issues/163. synaptic vesicle clustering The process that results in grouping synaptic vesicles in presynaptic structures. GOC:ans GOC:pr PMID:19900895 PMID:7568108 The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). paola 2011-07-27T01:26:49Z post-synaptic membrane assembly biological_process GO:0097104 postsynaptic membrane assembly The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). GOC:BHF GOC:sjp PMID:21424692 The aggregation, arrangement and bonding together of a set of components to form a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction. paola 2011-07-27T01:30:45Z pre-synaptic membrane assembly biological_process GO:0097105 Note that 'presynaptic membrane' in this term should not be mistaken with 'presynaptic active zone'. The latter encompasses more than the former, as it also includes the specialized cortical cytoskeletal matrix in the cell cortex of a presynaptic neuron. presynaptic membrane assembly The aggregation, arrangement and bonding together of a set of components to form a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction. GOC:BHF GOC:pr GOC:sjp PMID:15797875 PMID:18550748 The aggregation, arrangement and bonding together of a set of components to form a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. paola 2011-07-27T05:21:39Z PSD assembly post synaptic density assembly post-synaptic density assembly biological_process GO:0097107 postsynaptic density assembly The aggregation, arrangement and bonding together of a set of components to form a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse. GOC:BHF GOC:sjp PMID:21525273 The acidification of the synaptic vesicle lumen via transport of protons into the vesicle. The resulting electrochemical gradient powers neurotransmitter loading. paola 2012-10-25T09:03:34Z synaptic vesicle lumen pH reduction synaptic vesicle proton loading biological_process GO:0097401 synaptic vesicle lumen acidification The acidification of the synaptic vesicle lumen via transport of protons into the vesicle. The resulting electrochemical gradient powers neurotransmitter loading. GOC:dsf PMID:21172605 PMID:22875945 synaptic vesicle proton loading A specialization of the endomembrane system found in some classes of dendritic spines consisting of two or more closely apposed lamellae with interspersed electron dense material. The endomembrane component is continuous with the smooth endoplasmic reticulum. paola 2012-12-06T14:05:58Z NIF_Subcellular:sao725931194 dense material cellular_component GO:0097444 spine apparatus A specialization of the endomembrane system found in some classes of dendritic spines consisting of two or more closely apposed lamellae with interspersed electron dense material. The endomembrane component is continuous with the smooth endoplasmic reticulum. NIF_Subcellular:sao725931194 PMID:20400711 PMID:8987748 dense material NIF_Subcellular:sao1004601938 A synapse of a mossy fiber onto the dendrite of a granule cell; each mossy fiber can have up to 50 rosettes. paola 2013-02-21T07:42:52Z NIF_Subcellular:nlx_subcell_091021 cerebellar mossy fiber to granule cell synapse cellular_component GO:0097471 mossy fiber rosette A synapse of a mossy fiber onto the dendrite of a granule cell; each mossy fiber can have up to 50 rosettes. NIF_Subcellular:nlx_subcell_091021 http://en.wikipedia.org/wiki/Mossy_fiber_(cerebellum) cerebellar mossy fiber to granule cell synapse The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. cellular_component GO:0098563 intrinsic component of synaptic vesicle membrane The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. GOC:dos The component of the neuronal dense core vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. dos 2017-01-17T16:20:56Z cellular_component GO:0098674 extrinsic component of neuronal dense core vesicle membrane The component of the neuronal dense core vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. GOC:dos The component of the neuronal dense core vesicle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. dos 2017-01-17T16:22:44Z intrinsic to neuronal dense core granule membrane cellular_component GO:0098675 intrinsic component of neuronal dense core vesicle membrane The component of the neuronal dense core vesicle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. GOC:dos GOC:mah A ribbon synpase of an auditory hair cell of the cochlear. These ribbon synapses contain spherical synaptic ribbons and lack and arciform density. dos 2017-02-05T16:16:49Z cellular_component GO:0098683 cochlear hair cell ribbon synapse A ribbon synpase of an auditory hair cell of the cochlear. These ribbon synapses contain spherical synaptic ribbons and lack and arciform density. PMID:15626493 A ribbon synapse between a retinal photoreceptor cell (rod or cone) and a retinal bipolar cell. These contain a plate-like synaptic ribbon. dos 2017-02-05T16:26:27Z cellular_component GO:0098684 photoreceptor ribbon synapse A ribbon synapse between a retinal photoreceptor cell (rod or cone) and a retinal bipolar cell. These contain a plate-like synaptic ribbon. PMID:15626493 A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell. dos 2017-02-05T16:29:43Z cellular_component GO:0098685 Schaffer collateral - CA1 synapse A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell. PMID:16399689 One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell. dos 2017-02-05T16:29:58Z cellular_component GO:0098686 hippocampal mossy fiber to CA3 synapse One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell. DOI:10.1002/1096-9861 PMID:13869693 PMID:23264762 An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells. dos 2017-02-21T18:32:05Z cellular_component GO:0098688 parallel fiber to Purkinje cell synapse An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells. PMID:16623829 PMID:3209740 A synapse that uses glycine as a neurotransmitter. dos 2017-03-07T14:50:33Z cellular_component GO:0098690 glycinergic synapse A synapse that uses glycine as a neurotransmitter. GOC:dos A synapse that uses dopamine as a neurotransmitter. dos 2017-03-07T14:51:52Z cellular_component GO:0098691 dopaminergic synapse A synapse that uses dopamine as a neurotransmitter. GOC:dos Any process that modulates the frequency, rate or extent of the synaptic vesicle cycle. dos 2017-03-21T16:06:48Z biological_process GO:0098693 regulation of synaptic vesicle cycle Any process that modulates the frequency, rate or extent of the synaptic vesicle cycle. GOC:dos Any process that modulates the frequency, rate or extent of synaptic vesicle budding from presynaptic endocytic zone membrane. dos 2017-04-04T17:03:29Z biological_process GO:0098694 regulation of synaptic vesicle budding from presynaptic endocytic zone membrane Any process that modulates the frequency, rate or extent of synaptic vesicle budding from presynaptic endocytic zone membrane. GOC:dos Any inositol 1,4,5-trisphosphate receptor activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration. dos 2017-04-04T17:07:09Z IP3 receptor activity involved in regulation of postsynaptic cytosolic calcium levels molecular_function GO:0098695 inositol 1,4,5-trisphosphate receptor activity involved in regulation of postsynaptic cytosolic calcium levels Any inositol 1,4,5-trisphosphate receptor activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration. GOC:dos Any process that modulates the frequency, rate or extent of neurotransmitter receptor localization to postsynaptic specialization membrane. dos 2017-04-04T16:33:38Z biological_process GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane Any process that modulates the frequency, rate or extent of neurotransmitter receptor localization to postsynaptic specialization membrane. GOC:dos Any ryanodine-sensitive calcium-release channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration. dos 2017-04-04T17:11:38Z molecular_function GO:0098697 ryanodine-sensitive calcium-release channel activity involved in regulation of postsynaptic cytosolic calcium levels Any ryanodine-sensitive calcium-release channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration. GOC:dos The aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane. dos 2017-04-04T17:22:01Z biological_process GO:0098698 postsynaptic specialization assembly The aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane. GOC:dos The action of a molecule that contributes to the structural integrity of a presynaptic actin cytoskeleton. dos 2017-06-09T18:33:07Z molecular_function GO:0098699 structural constituent of presynaptic actin cytoskeleton The action of a molecule that contributes to the structural integrity of a presynaptic actin cytoskeleton. GOC:dos The active transport of neurotransmitters into a synaptic vesicle. This import is fuelled by an electrochemical gradient across the vesicle membrane, established by the action of proton pumps. neurotransmitter import into synaptic vesicle neurotransmitter uptake into synaptic vesicle synaptic vesicle neurotransmitter loading biological_process GO:0098700 neurotransmitter loading into synaptic vesicle The active transport of neurotransmitters into a synaptic vesicle. This import is fuelled by an electrochemical gradient across the vesicle membrane, established by the action of proton pumps. GOC:PARL GOC:bf GOC:pad PMID:10099709 PMID:15217342 neurotransmitter uptake into synaptic vesicle PMID:15217342 synaptic vesicle neurotransmitter loading The part of a synapse that is part of the presynaptic cell. presynaptic terminal cellular_component GO:0098793 presynapse The part of a synapse that is part of the presynaptic cell. GOC:dos The part of a synapse that is part of the post-synaptic cell. cellular_component GO:0098794 postsynapse The part of a synapse that is part of the post-synaptic cell. GOC:dos The directed movement of neurotransmitter molecules from the extrasynaptic space into the presynaptic cytosol. biological_process GO:0098810 neurotransmitter reuptake The directed movement of neurotransmitter molecules from the extrasynaptic space into the presynaptic cytosol. GOC:dos The low level of synaptic transmission that occurs via spontaneous neurotransmitter release into the synaptic cleft in the absence of a presynaptic action potential. basal synaptic transmission biological_process GO:0098814 This is typically measured via detection of mini excitatory post-synaptic currents (mEPSCs). spontaneous synaptic transmission The low level of synaptic transmission that occurs via spontaneous neurotransmitter release into the synaptic cleft in the absence of a presynaptic action potential. PMID:20200227 basal synaptic transmission PMID:16899074 A protein complex that spans the synaptic cleft and has parts in both the pre- and post-synaptic membranes. cellular_component GO:0098820 trans-synaptic protein complex A protein complex that spans the synaptic cleft and has parts in both the pre- and post-synaptic membranes. PMID:20200227 An endosome present in the presynapse that fuses with endocytic vesicles arising in the presynaptic endocytic zone. This organelle is believed to be involved in regeneration of synaptic vesicles. cellular_component GO:0098830 As of 2015, there is still controversy over the nature of presynaptic endosomes and their relationship to regular endosomes. See Jahne et al., 2015 (PMID:25939282) for details. presynaptic endosome An endosome present in the presynapse that fuses with endocytic vesicles arising in the presynaptic endocytic zone. This organelle is believed to be involved in regeneration of synaptic vesicles. PMID:20200227 PMID:25939282 A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles. cortex of presynaptic active zone presynaptic zone cortex cellular_component GO:0098831 presynaptic active zone cytoplasmic component A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles. GOC:dos A specialized region of the plasma membrane and underlying cytoplasm which surround the the active zone, into which synaptic vesicle membranes are recycled following exocytosis. It is especially enriched in endocytic proteins following intense activity. cellular_component GO:0098833 May be identical to periactive zone? presynaptic endocytic zone A specialized region of the plasma membrane and underlying cytoplasm which surround the the active zone, into which synaptic vesicle membranes are recycled following exocytosis. It is especially enriched in endocytic proteins following intense activity. PMID:17455288 The cytoplasmic component of the presynaptic endocytic zone. cortex of presynaptic endocytic zone cellular_component GO:0098834 presynaptic endocytic zone cytoplasmic component The cytoplasmic component of the presynaptic endocytic zone. GOC:dos The region of the presynaptic membrane that is part of the presynaptic endocytic zone - where synaptic vesicles are endocytosed and recycled following release. cellular_component GO:0098835 presynaptic endocytic zone membrane The region of the presynaptic membrane that is part of the presynaptic endocytic zone - where synaptic vesicles are endocytosed and recycled following release. GOC:dos A recycling endosome of the postsynapse. In postsynaptic terminals with dendritic spines, it is typically located at the base of a dendritic spine. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane. In some cases at least, this recycling is activated by postsynaptic signalling and so can play a role in long term potentiation. postsynaptic endosomal recycling compartment postsynaptic recycling outpost cellular_component GO:0098837 postsynaptic recycling endosome A recycling endosome of the postsynapse. In postsynaptic terminals with dendritic spines, it is typically located at the base of a dendritic spine. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane. In some cases at least, this recycling is activated by postsynaptic signalling and so can play a role in long term potentiation. PMID:20820847 postsynaptic endosomal recycling compartment PMID:20820847 postsynaptic recycling outpost PMID:20820847 The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. cellular_component GO:0098839 postsynaptic density membrane The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. GOC:dos An early endosome of the postsynapse. It acts as the major sorting station on the endocytic pathway, targeting neurotransmitter receptors for degregation or recycling. cellular_component GO:0098842 Commonly used markers for postsynaptic early endosomes include RAB5A and EEA1. postsynaptic early endosome An early endosome of the postsynapse. It acts as the major sorting station on the endocytic pathway, targeting neurotransmitter receptors for degregation or recycling. PMID:19603039 PMID:20820847 PMID:24727350 A stably positioned site of clathrin adjacent and physically attached to the postsynaptic specialization, which is the site of endocytosis of post-synaptic proteins. cellular_component GO:0098843 postsynaptic endocytic zone A stably positioned site of clathrin adjacent and physically attached to the postsynaptic specialization, which is the site of endocytosis of post-synaptic proteins. PMID:17880892 The region of the postsynaptic membrane that is part of the postsynaptic endocytic zone. This region of membrane is associated with stable clathrin puncta. cellular_component GO:0098844 postsynaptic endocytic zone membrane The region of the postsynaptic membrane that is part of the postsynaptic endocytic zone. This region of membrane is associated with stable clathrin puncta. PMID:17880892 An endosomal compartment that is part of the post-synapse. Only early and recycling endosomes are typically present in the postsynapse. cellular_component GO:0098845 postsynaptic endosome An endosomal compartment that is part of the post-synapse. Only early and recycling endosomes are typically present in the postsynapse. PMID:20820847 The component of the synaptic vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. cellular_component GO:0098850 extrinsic component of synaptic vesicle membrane The component of the synaptic vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. GOC:dos The actin cytoskeleton that is part of a postsynapse cellular_component GO:0098871 postsynaptic actin cytoskeleton The actin cytoskeleton that is part of a postsynapse GOC:dos A G protein-coupled neurotransmitter receptor activity occurring in the postsynaptic membrane, that is involved in regulating the cytosolic concentration of calcium ions in the postsynapse. G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels molecular_function GO:0098872 G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration A G protein-coupled neurotransmitter receptor activity occurring in the postsynaptic membrane, that is involved in regulating the cytosolic concentration of calcium ions in the postsynapse. GOC:dos G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels The directed movement of neurotransmitter receptor to the plasma membrane in transport vesicles. biological_process GO:0098877 neurotransmitter receptor transport to plasma membrane The directed movement of neurotransmitter receptor to the plasma membrane in transport vesicles. GOC:dos The action of a molecule that contributes to the structural integrity of a postsynaptic specialization. molecular_function GO:0098879 structural constituent of postsynaptic specialization The action of a molecule that contributes to the structural integrity of a postsynaptic specialization. GOC:dos A process which maintains the organization and the arrangement of proteins in the presynaptic specialization. biological_process GO:0098880 maintenance of postsynaptic specialization structure A process which maintains the organization and the arrangement of proteins in the presynaptic specialization. GOC:dos The exocytic fusion of neurotransmitter receptor containing vesicles with a plasma-membrane resulting in the integration of NT receptors with the plasma-membrane. This process includes tethering and docking steps that prepare vesicles for fusion. neurotransmitter receptor insertion biological_process GO:0098881 exocytic insertion of neurotransmitter receptor to plasma membrane The exocytic fusion of neurotransmitter receptor containing vesicles with a plasma-membrane resulting in the integration of NT receptors with the plasma-membrane. This process includes tethering and docking steps that prepare vesicles for fusion. PMID:19503082 The action of a molecule that contributes to the structural integrity of a presynaptic active zone. structural constituent of active zone molecular_function GO:0098882 structural constituent of presynaptic active zone The action of a molecule that contributes to the structural integrity of a presynaptic active zone. GOC:dos structural constituent of active zone A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared. synapse clearance synapse disassembly synapse elimination synapse removal biological_process GO:0098883 synapse pruning A cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared. GOC:dos PMID:12062020 PMID:18083105 PMID:22632716 PMID:29844190 synapse clearance GOC:aruk GOC:bc PMID:22632716 synapse disassembly PMID:12062020 synapse elimination GOC:aruk GOC:bc PMID:18083105 PMID:29844190 synapse removal GOC:aruk GOC:bc PMID:22632716 A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor from the postsynaptic membrane endocytic zone into an endocytic vesicle. postsynaptic neurotransmitter receptor endocytosis biological_process GO:0098884 Added parent as requested in https://github.com/geneontology/synapse/issues/230. postsynaptic neurotransmitter receptor internalization A receptor-mediated endocytosis process that results in the internalization of a neurotransmitter receptor from the postsynaptic membrane endocytic zone into an endocytic vesicle. GOC:dos postsynaptic neurotransmitter receptor endocytosis Any process that modifies the structure of a postsynaptic actin cytoskeleton. postsynaptic actin cytoskeleton remodelling biological_process GO:0098885 This class does not cover assembly or disassembly of synapses, only the modification/remodelling of existing ones. modification of postsynaptic actin cytoskeleton Any process that modifies the structure of a postsynaptic actin cytoskeleton. GOC:dos The directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles. postsynaptic neurotransmitter receptor endosomal trafficking biological_process GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane The directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles. GOC:dos The component of the presynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. extrinsic component of presynaptic plasma membrane cellular_component GO:0098888 extrinsic component of presynaptic membrane The component of the presynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. GOC:autophagy GOC:mf The component of the presynaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. intrinsic to presynaptic membrane cellular_component GO:0098889 intrinsic component of presynaptic membrane The component of the presynaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. GOC:dos GOC:mah The component of the postsynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. cellular_component GO:0098890 extrinsic component of postsynaptic membrane The component of the postsynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. GOC:autophagy GOC:mf The component of the presynaptic active zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. cellular_component GO:0098891 extrinsic component of presynaptic active zone membrane The component of the presynaptic active zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. GOC:autophagy GOC:mf The component of the postsynaptic specialization membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. cellular_component GO:0098892 extrinsic component of postsynaptic specialization membrane The component of the postsynaptic specialization membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. GOC:autophagy GOC:mf The component of the postsynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. cellular_component GO:0098893 extrinsic component of postsynaptic endocytic zone The component of the postsynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. GOC:autophagy GOC:mf The component of the presynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. cellular_component GO:0098894 extrinsic component of presynaptic endocytic zone membrane The component of the presynaptic endocytic zone membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. GOC:autophagy GOC:mf The lipid bilayer surrounding a postsynaptic endosome. cellular_component GO:0098895 postsynaptic endosome membrane The lipid bilayer surrounding a postsynaptic endosome. GOC:pz The lipid bilayer surrounding a postsynaptic early endosome. cellular_component GO:0098896 postsynaptic early endosome membrane The lipid bilayer surrounding a postsynaptic early endosome. GOC:pz The lipid bilayer surrounding the spine apparatus. cellular_component GO:0098897 spine apparatus membrane The lipid bilayer surrounding the spine apparatus. GOC:mah The volume enclosed by the spine apparatus membrane. cellular_component GO:0098899 spine apparatus lumen The volume enclosed by the spine apparatus membrane. GOC:dos The action of a molecule that contributes to the structural integrity of a synapse. molecular_function GO:0098918 structural constituent of synapse The action of a molecule that contributes to the structural integrity of a synapse. GOC:dos The action of a molecule that contributes to the structural integrity of a postsynaptic density. molecular_function GO:0098919 structural constituent of postsynaptic density The action of a molecule that contributes to the structural integrity of a postsynaptic density. GOC:dos Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand. biological_process GO:0098920 retrograde trans-synaptic signaling by lipid Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a lipid ligand. GOC:dos Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an endocannabinoid ligand. biological_process GO:0098921 retrograde trans-synaptic signaling by endocannabinoid Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an endocannabinoid ligand. GOC:dos Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an soluble gas ligand. biological_process GO:0098923 retrograde trans-synaptic signaling by soluble gas Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by an soluble gas ligand. GOC:dos Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide. biological_process GO:0098924 retrograde trans-synaptic signaling by nitric oxide Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide. GOC:dos Modulation of synaptic transmission by cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide. biological_process GO:0098925 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission Modulation of synaptic transmission by cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by nitric oxide. GOC:dos Signal transduction in which the initial step occurs in a postsynapse. postsynaptic signaling pathway biological_process GO:0098926 Do not directly annotate. This term is intended for automatically grouping annotations to signal transduction classes extended with has_start_location/occurs_in postsynapse or one of its parts. postsynaptic signal transduction Signal transduction in which the initial step occurs in a postsynapse. GOC:dos postsynaptic signaling pathway Signal transduction in which the initial step occurs in a presynapse. presynaptic signaling pathway biological_process GO:0098928 Do not directly annotate. This term intended for grouping. Annotate to either a subclass or to some other subclass of signal transduction extended with has_start_location/occurs_in presynapse or one of its parts. Such extensions will result in automatic annotation to this term. presynaptic signal transduction Signal transduction in which the initial step occurs in a presynapse. GOC:dos presynaptic signaling pathway The component of the spine apparatus membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. cellular_component GO:0098929 extrinsic component of spine apparatus membrane The component of the spine apparatus membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. GOC:dos The directed movement of organelles or molecules along microtubules in axons. Wikipedia:Axoplasmic_transport axon cargo transport axoplasmic transport biological_process GO:0098930 axonal transport The directed movement of organelles or molecules along microtubules in axons. ISBN:0815316194 The directed movement of organelles or molecules along microtubules in a dendrite from the postsynapse towards the cell body. biological_process GO:0098934 retrograde dendritic transport The directed movement of organelles or molecules along microtubules in a dendrite from the postsynapse towards the cell body. GOC:dos The directed movement of organelles or molecules along microtubules in dendrites. dendrite cargo transport biological_process GO:0098935 dendritic transport The directed movement of organelles or molecules along microtubules in dendrites. ISBN:0815316194 The component of the postsynaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. intrinsic to postsynaptic membrane cellular_component GO:0098936 intrinsic component of postsynaptic membrane The component of the postsynaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. GOC:dos GOC:mah The directed movement of organelles or molecules along microtubules from the cell body toward the postsynapse in dendrites. biological_process GO:0098937 anterograde dendritic transport The directed movement of organelles or molecules along microtubules from the cell body toward the postsynapse in dendrites. ISBN:0815316194 The actin cytoskeleton that is part of a dendritic spine. cellular_component GO:0098938 actin cytoskeleton of dendritic spine The actin cytoskeleton that is part of a dendritic spine. GOC:dos The directed movement of mitochondria along microtubules in nerve cell dendrites. biological_process GO:0098939 dendritic transport of mitochondrion The directed movement of mitochondria along microtubules in nerve cell dendrites. GOC:ai Cell-cell signaling from presynapse to postynapse, across the synaptic cleft, mediated by nitric oxide. biological_process GO:0098940 anterograde trans-synaptic signaling by nitric oxide Cell-cell signaling from presynapse to postynapse, across the synaptic cleft, mediated by nitric oxide. GOC:dos Cell-cell signaling from presynapse to postynapse, across the synaptic cleft, mediated by a trans-synaptic protein complex. biological_process GO:0098941 anterograde trans-synaptic signaling by trans-synaptic protein complex Cell-cell signaling from presynapse to postynapse, across the synaptic cleft, mediated by a trans-synaptic protein complex. GOC:dos Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by trans-synaptic protein complex. biological_process GO:0098942 retrograde trans-synaptic signaling by trans-synaptic protein complex Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by trans-synaptic protein complex. GOC:dos The directed movement of neurotransmitter receptor from the postsynaptic endosome in tranpsort vesicles to the lysosome for degradation. postsynaptic neurotransmitter receptor endosomal trafficking biological_process GO:0098943 neurotransmitter receptor transport, postsynaptic endosome to lysosome The directed movement of neurotransmitter receptor from the postsynaptic endosome in tranpsort vesicles to the lysosome for degradation. GOC:dos The lipid bilayer surrounding a postsynaptic recycling endosome. cellular_component GO:0098944 postsynaptic recycling endosome membrane The lipid bilayer surrounding a postsynaptic recycling endosome. GOC:pz The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. intrinsic to presynaptic acive zone membrane cellular_component GO:0098945 intrinsic component of presynaptic active zone membrane The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. GOC:dos GOC:mah The component of the presynaptic endocytic zone membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. intrinsic to presynaptic acive zone membrane cellular_component GO:0098946 intrinsic component of presynaptic endocytic zone membrane The component of the presynaptic endocytic zone membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. GOC:dos GOC:mah The component of the postsynaptic endocytic zone membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. intrinsic to postsynaptic acive zone membrane cellular_component GO:0098947 intrinsic component of postsynaptic endocytic zone membrane The component of the postsynaptic endocytic zone membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. GOC:dos GOC:mah The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. intrinsic to postsynaptic specialization membrane cellular_component GO:0098948 intrinsic component of postsynaptic specialization membrane The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. GOC:dos GOC:mah The component of the postsynaptic endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. intrinsic to postsynaptic endosome membrane cellular_component GO:0098949 intrinsic component of postsynaptic endosome membrane The component of the postsynaptic endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. GOC:dos GOC:mah The component of the postsynaptic early endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. intrinsic to postsynaptic early endosome membrane cellular_component GO:0098950 intrinsic component of postsynaptic early endosome membrane The component of the postsynaptic early endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. GOC:dos GOC:mah The component of the postsynaptic recycling endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. intrinsic to postsynaptic recycling endosome membrane cellular_component GO:0098951 intrinsic component of postsynaptic recycling endosome membrane The component of the postsynaptic recycling endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. GOC:dos GOC:mah The component of the spine apparatus membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. intrinsic to spine apparatus membrane cellular_component GO:0098952 intrinsic component of spine apparatus membrane The component of the spine apparatus membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. GOC:dos GOC:mah The lipid bilayer surrounding a presynaptic endosome. cellular_component GO:0098954 presynaptic endosome membrane The lipid bilayer surrounding a presynaptic endosome. GOC:pz The component of the presynaptic endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. intrinsic to presynaptic endosome membrane cellular_component GO:0098955 intrinsic component of presynaptic endosome membrane The component of the presynaptic endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. GOC:dos GOC:mah The directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse. anterograde axon transport of mitochondria biological_process GO:0098957 anterograde axonal transport of mitochondrion The directed movement of mitochondria along microtubules in axons away from the cell body and towards the presynapse. GOC:dos The directed movement of mitochondria along microtubules in axons towards the cell body and away from the presynapse. retrograde axon transport of mitochondria biological_process GO:0098958 retrograde axonal transport of mitochondrion The directed movement of mitochondria along microtubules in axons towards the cell body and away from the presynapse. GOC:dos The directed movement of mitochondria along microtubules in dendrites towards the cell body and away from the postsynapse. retrograde dendrite transport of mitochondria biological_process GO:0098959 retrograde dendritic transport of mitochondrion The directed movement of mitochondria along microtubules in dendrites towards the cell body and away from the postsynapse. GOC:dos The directed movement of a ribonucleoprotein complex along microtubules in nerve cell dendrites. dendritic transport of RNP complex biological_process GO:0098961 dendritic transport of ribonucleoprotein complex The directed movement of a ribonucleoprotein complex along microtubules in nerve cell dendrites. GOC:dos Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors. biological_process GO:0098962 regulation of postsynaptic neurotransmitter receptor activity Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity involved in synaptic transmission. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors. GOC:dos The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites. dendritic transport of mRNA RNP complex biological_process GO:0098963 dendritic transport of messenger ribonucleoprotein complex The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites. GOC:dos The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites towards the postsynapse. anterograde dendritic transport of mRNA RNP complex biological_process GO:0098964 anterograde dendritic transport of messenger ribonucleoprotein complex The directed movement of a messenger ribonucleoprotein complex along microtubules in nerve cell dendrites towards the postsynapse. GOC:dos The portion of the extracellular matrix that lies within the synaptic cleft. ECM of synaptic cleft synaptic cleft ECM cellular_component GO:0098965 extracellular matrix of synaptic cleft The portion of the extracellular matrix that lies within the synaptic cleft. GOC:dos The portion of the extracellular matrix that lies within the perisynaptic space. extrasynaptic extracellular matrix perisynaptic ECM cellular_component GO:0098966 perisynaptic extracellular matrix The portion of the extracellular matrix that lies within the perisynaptic space. GOC:dos The exocytic fusion of neurotransmitter receptor containing vesicles with the postsynaptic membrane resulting in the integration of NT receptors, enabling them to participate in neurotransmitter reception. This process includes tethering and docking steps that prepare vesicles for fusion. biological_process GO:0098967 exocytic insertion of neurotransmitter receptor to postsynaptic membrane The exocytic fusion of neurotransmitter receptor containing vesicles with the postsynaptic membrane resulting in the integration of NT receptors, enabling them to participate in neurotransmitter reception. This process includes tethering and docking steps that prepare vesicles for fusion. PMID:19503082 Vesicle-mediated transport of a neurotransmitter receptor complex from the postsynaptic membrane to the postsynaptic early endosome. biological_process GO:0098968 neurotransmitter receptor transport postsynaptic membrane to endosome Vesicle-mediated transport of a neurotransmitter receptor complex from the postsynaptic membrane to the postsynaptic early endosome. GOC:dos The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles. biological_process GO:0098969 neurotransmitter receptor transport to postsynaptic membrane The directed movement of neurotransmitter receptor to the postsynaptic membrane in transport vesicles. GOC:dos The process by which diffusing neurotransmitter receptor becomes trapped at the postsynaptic specialization membrane. This is typically due to interaction with components of the post-synaptic specialization. biological_process GO:0098970 postsynaptic neurotransmitter receptor diffusion trapping The process by which diffusing neurotransmitter receptor becomes trapped at the postsynaptic specialization membrane. This is typically due to interaction with components of the post-synaptic specialization. PMID:18832033 The directed movement of a neurotransmitter receptor complex along microtubules in nerve cell dendrites towards the postsynapse. biological_process GO:0098971 anterograde dendritic transport of neurotransmitter receptor complex The directed movement of a neurotransmitter receptor complex along microtubules in nerve cell dendrites towards the postsynapse. GOC:dos The directed movement of mitochondria along microtubules in dendrites towards the postsynapse and away from the cell body. biological_process GO:0098972 anterograde dendritic transport of mitochondrion The directed movement of mitochondria along microtubules in dendrites towards the postsynapse and away from the cell body. GOC:dos The action of a molecule that contributes to the structural integrity of a postsynaptic actin cytoskeleton. molecular_function GO:0098973 structural constituent of postsynaptic actin cytoskeleton The action of a molecule that contributes to the structural integrity of a postsynaptic actin cytoskeleton. GOC:dos A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton. biological_process GO:0098974 postsynaptic actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the postsynaptic actin cytoskeleton. GOC:dos A synapse that uses glutamate as a neurotransmitter. cellular_component GO:0098978 glutamatergic synapse A synapse that uses glutamate as a neurotransmitter. GOC:dos A synapse that uses acetylcholine as a neurotransmitter. cellular_component GO:0098981 cholinergic synapse A synapse that uses acetylcholine as a neurotransmitter. GOC:dos A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory. cellular_component GO:0098982 GABA-ergic synapse A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory. GOC:dos Any process that regulates the modification of synaptic structure and as a result regulates synaptic transmission. biological_process GO:0098987 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. regulation of modification of synapse structure, modulating synaptic transmission Any process that regulates the modification of synaptic structure and as a result regulates synaptic transmission. GOC:dos A series of molecular signals initiated by glutamate binding to an AMPA-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription. biological_process GO:0098990 AMPA selective glutamate receptor signaling pathway A series of molecular signals initiated by glutamate binding to an AMPA-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription. GOC:dos ISBN:9780071120005 A series of molecular signals initiated by glutamate binding to an kainate-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription. biological_process GO:0098991 kainate selective glutamate receptor signaling pathway A series of molecular signals initiated by glutamate binding to an kainate-selective glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription. GOC:signaling ISBN:9780071120005 A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals. cellular_component GO:0098992 neuronal dense core vesicle A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals. GOC:dos ISBN:978-0-07-181001-2 Wikipedia:Neuropeptide&oldid=713905176 The component of the synaptic vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. cellular_component GO:0098993 anchored component of synaptic vesicle membrane The component of the synaptic vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. GOC:dos The component of the postsynaptic early endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. cellular_component GO:0098998 extrinsic component of postsynaptic early endosome membrane The component of the postsynaptic early endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. GOC:autophagy GOC:mf The component of the postsynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. cellular_component GO:0098999 extrinsic component of postsynaptic endosome membrane The component of the postsynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. GOC:autophagy GOC:mf Any vesicle-mediated transport that occurs in a synapse biological_process GO:0099003 vesicle-mediated transport in synapse Any vesicle-mediated transport that occurs in a synapse GOC:dos The component of the postsynaptic recycling endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. cellular_component GO:0099005 extrinsic component of postsynaptic recycling endosome membrane The component of the postsynaptic recycling endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. GOC:autophagy GOC:mf The component of the presynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. cellular_component GO:0099007 extrinsic component of presynaptic endosome membrane The component of the presynaptic endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. GOC:autophagy GOC:mf Any process that modifies the structure of a postsynapse. synapse remodelling biological_process GO:0099010 This class does not cover assembly or disassembly of postsynapses, only the modification/remodelling of existing ones. modification of postsynaptic structure Any process that modifies the structure of a postsynapse. GOC:dos The lipid bilayer surrounding a neuronal dense core vesicle. cellular_component GO:0099012 neuronal dense core vesicle membrane The lipid bilayer surrounding a neuronal dense core vesicle. GOC:dos The volume enclosed by a neuronal dense core vesicle membrane. cellular_component GO:0099013 neuronal dense core vesicle lumen The volume enclosed by a neuronal dense core vesicle membrane. GOC:dos The component of the postsynaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. cellular_component GO:0099025 anchored component of postsynaptic membrane The component of the postsynaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. GOC:dos The component of the presynaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. anchored component of presynaptic plasma membrane cellular_component GO:0099026 anchored component of presynaptic membrane The component of the presynaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. GOC:dos The component of the presynaptic endocytic zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. cellular_component GO:0099027 anchored component of presynaptic endocytic zone membrane The component of the presynaptic endocytic zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. GOC:dos The component of the postynaptic endocytic zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. cellular_component GO:0099028 anchored component of postynaptic endocytic zone membrane The component of the postynaptic endocytic zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. GOC:dos The component of the presynaptic active zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. cellular_component GO:0099029 anchored component of presynaptic active zone membrane The component of the presynaptic active zone membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. GOC:dos The component of the postsynaptic specialization membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. cellular_component GO:0099030 anchored component of postsynaptic specialization membrane The component of the postsynaptic specialization membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. GOC:dos The component of the postsynaptic density membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. cellular_component GO:0099031 anchored component of postsynaptic density membrane The component of the postsynaptic density membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. GOC:dos The component of the postsynaptic early endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. cellular_component GO:0099032 anchored component of postsynaptic early endosome membrane The component of the postsynaptic early endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. GOC:dos The component of the postsynaptic recycling endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. cellular_component GO:0099033 anchored component of postsynaptic recycling endosome membrane The component of the postsynaptic recycling endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. GOC:dos The component of the postsynaptic endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. cellular_component GO:0099034 anchored component of postsynaptic endosome membrane The component of the postsynaptic endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. GOC:dos The component of the spine apparatus membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. cellular_component GO:0099035 anchored component of spine apparatus membrane The component of the spine apparatus membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. GOC:dos The component of the neuronal dense core vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. cellular_component GO:0099036 anchored component of neuronal dense core vesicle membrane The component of the neuronal dense core vesicle membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. GOC:dos The component of the presynaptic endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. cellular_component GO:0099037 anchored component of presynaptic endosome membrane The component of the presynaptic endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. GOC:dos The aggregation, arrangement and bonding together of a set of components to form a presynapse. presynapse biogenesis presynaptic terminal assembly biological_process GO:0099054 presynapse assembly The aggregation, arrangement and bonding together of a set of components to form a presynapse. GOC:PARL GOC:bf GOC:dos PMID:24449494 presynapse biogenesis GOC:mah presynaptic terminal assembly PMID:24449494 The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. cellular_component GO:0099055 integral component of postsynaptic membrane The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. GOC:dos The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. integral component of presynaptic plasma membrane cellular_component GO:0099056 integral component of presynaptic membrane The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. GOC:dos The component of the presynaptic endocytic zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. cellular_component GO:0099057 integral component of presynaptic endocytic zone membrane The component of the presynaptic endocytic zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. GOC:dos The component of the postsynaptic endocytic zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. cellular_component GO:0099058 integral component of postsynaptic endocytic zone membrane The component of the postsynaptic endocytic zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. GOC:dos The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. cellular_component GO:0099059 integral component of presynaptic active zone membrane The component of the presynaptic active zone membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. GOC:dos The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. cellular_component GO:0099060 integral component of postsynaptic specialization membrane The component of the postsynaptic specialization membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. GOC:dos The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. cellular_component GO:0099061 integral component of postsynaptic density membrane The component of the postsynaptic density membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. GOC:dos The component of the postsynaptic early endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. cellular_component GO:0099062 integral component of postsynaptic early endosome membrane The component of the postsynaptic early endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. GOC:dos The component of the postsynaptic recycling endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. cellular_component GO:0099063 integral component of postsynaptic recycling endosome membrane The component of the postsynaptic recycling endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. GOC:dos The component of the postsynaptic endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. cellular_component GO:0099064 integral component of postsynaptic endosome membrane The component of the postsynaptic endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. GOC:dos The component of the spine apparatus membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. cellular_component GO:0099065 integral component of spine apparatus membrane The component of the spine apparatus membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. GOC:dos The component of the neuronal dense core vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. cellular_component GO:0099066 integral component of neuronal dense core vesicle membrane The component of the neuronal dense core vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. GOC:dos The component of the presynaptic endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. cellular_component GO:0099067 integral component of presynaptic endosome membrane The component of the presynaptic endosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. GOC:dos Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane. biological_process GO:0099072 regulation of postsynaptic membrane neurotransmitter receptor levels Any process that regulates the the local concentration of neurotransmitter receptor at the postsynaptic membrane. GOC:dos Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide. biological_process GO:0099082 retrograde trans-synaptic signaling by neuropeptide Cell-cell signaling from postsynapse to presynapse, across the synaptic cleft, mediated by a neuropeptide. GOC:PARL GOC:bf GOC:dos PMID:19448629 Modulation of synaptic transmittion by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide. biological_process GO:0099083 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. retrograde trans-synaptic signaling by neuropeptide, modulating synaptic transmission Modulation of synaptic transmittion by cell-cell signaling across the synaptic cleft from postsynapse to presynapse, mediated by a neuropeptide. GOC:PARL GOC:bf GOC:dos PMID:19448629 A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic specialization, a structure that lies adjacent to the cytoplasmic face of the postsynaptic membrane. paola 2011-07-27T05:17:12Z post synaptic specialization organization post-synaptic specialization organization postsynaptic specialization organisation biological_process GO:0099084 postsynaptic specialization organization A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic specialization, a structure that lies adjacent to the cytoplasmic face of the postsynaptic membrane. GOC:BHF GOC:sjp PMID:21525273 PMID:26834556 The directed movement of a messenger ribonucleoprotein complex along microtubules in axons, towards the presynapse. anterograde axonal transport of mRNA RNP complex biological_process GO:0099087 anterograde axonal transport of messenger ribonucleoprotein complex The directed movement of a messenger ribonucleoprotein complex along microtubules in axons, towards the presynapse. GOC:dos PMID:26586091 The directed movement of a messenger ribonucleoprotein complex along microtubules in axons. axonal transport of mRNA RNP complex biological_process GO:0099088 axonal transport of messenger ribonucleoprotein complex The directed movement of a messenger ribonucleoprotein complex along microtubules in axons. GOC:dos PMID:26586091 The directed movement of endoplasmic reticulum into a postsynaptic compartment such as a dendritic spine. establishment of ER localization to postsynapse biological_process GO:0099089 establishment of endoplasmic reticulum localization to postsynapse The directed movement of endoplasmic reticulum into a postsynaptic compartment such as a dendritic spine. GOC:dos PMID:21151132 establishment of ER localization to postsynapse GOC:dos A network of proteins adjacent to the postsynaptic membrane. Its major components include the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. cellular_component GO:0099091 postsynaptic specialization, intracellular component A network of proteins adjacent to the postsynaptic membrane. Its major components include the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. GOC:dos A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. cellular_component GO:0099092 postsynaptic density, intracellular component A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. GOC:dos Any G-protein gated potassium channel activity that is involved regulation of postsynaptic membrane potential. molecular_function GO:0099102 G-protein gated potassium channel activity involved in regulation of postsynaptic membrane potential Any G-protein gated potassium channel activity that is involved regulation of postsynaptic membrane potential. GOC:dos PMID:9429760 Activation potassium ion channel activity via direct interaction with a potassium ion channel during G protein-coupled receptor signaling. potassium channel activator activity involved in G-protein coupled receptor signaling pathway molecular_function GO:0099108 Examples include G-protein beta-gamma complexes that bind to and activate potassium channels. potassium channel activator activity involved in G protein-coupled receptor signaling pathway Activation potassium ion channel activity via direct interaction with a potassium ion channel during G protein-coupled receptor signaling. PMID:9429760 Any process that decreases the concentration of calcium ions in the presynaptic cytosol. biological_process GO:0099113 negative regulation of presynaptic cytosolic calcium concentration Any process that decreases the concentration of calcium ions in the presynaptic cytosol. GOC:dos A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton. dos 2017-06-09T18:34:19Z biological_process GO:0099140 presynaptic actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins in the presynaptic actin cytoskeleton. GOC:dos The actin cytoskeleton that is part of a presynapse dos 2017-06-09T18:36:19Z cellular_component GO:0099143 presynaptic actin cytoskeleton The actin cytoskeleton that is part of a presynapse GOC:dos The component of the synaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. dos 2017-05-25T17:25:19Z cellular_component GO:0099144 anchored component of synaptic membrane The component of the synaptic membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. GOC:dos Any process that modulates the frequency, rate or extent of exocytic fusion of neurotransmitter receptor containing vesicles into the postsynaptic membrane. dos 2017-06-09T18:49:26Z biological_process GO:0099145 regulation of exocytic insertion of neurotransmitter receptor to postsynaptic membrane Any process that modulates the frequency, rate or extent of exocytic fusion of neurotransmitter receptor containing vesicles into the postsynaptic membrane. GOC:dos The component of the postsynaptic density membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. dos 2017-07-05T10:43:24Z intrinsic to postsynaptic specialization membrane cellular_component GO:0099146 intrinsic component of postsynaptic density membrane The component of the postsynaptic density membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. GOC:dos GOC:mah The component of the postsynaptic density membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. dos 2017-07-05T10:44:43Z cellular_component GO:0099147 extrinsic component of postsynaptic density membrane The component of the postsynaptic density membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. GOC:autophagy GOC:mf Any process that modulates the frequency, rate or extent of synaptic vesicle docking. dos 2017-07-05T13:10:10Z biological_process GO:0099148 regulation of synaptic vesicle docking Any process that modulates the frequency, rate or extent of synaptic vesicle docking. GOC:dos Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse. dos 2017-07-05T13:13:49Z regulation of postsynaptic neurotransmitter receptor endocytosis biological_process GO:0099149 regulation of postsynaptic neurotransmitter receptor internalization Any process that modulates the frequency, rate or extent of endocytosis of neurotransmitter receptor at the postsynapse. GOC:ai regulation of postsynaptic neurotransmitter receptor endocytosis Any process that modulates the frequency, rate or extent of postsynaptic specialization assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization. dos 2017-07-05T13:20:48Z biological_process GO:0099150 regulation of postsynaptic specialization assembly Any process that modulates the frequency, rate or extent of postsynaptic specialization assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic specialization. GOC:dos Any process that modulates the frequency, rate or extent of postsynaptic density assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic density. dos 2017-07-05T13:20:48Z biological_process GO:0099151 regulation of postsynaptic density assembly Any process that modulates the frequency, rate or extent of postsynaptic density assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynaptic density. GOC:dos Any process that modulates the frequency, rate or extent of the directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles. dos 2017-08-25T15:01:11Z biological_process GO:0099152 regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane Any process that modulates the frequency, rate or extent of the directed movement of neurotransmitter receptor from the postsynaptic endosome to the postsynaptic membrane in transport vesicles. GOC:dos PMID:20098723 A synapse that uses serotonin as a neurotransmitter. dos 2017-07-05T14:22:05Z cellular_component GO:0099154 serotonergic synapse A synapse that uses serotonin as a neurotransmitter. GOC:dos Transynaptic signaling in which the ligand is carried across the synapse by an exosome. dos 2017-07-05T16:49:44Z exosome mediated transynaptic signalling biological_process GO:0099157 trans-synaptic signalling via exosome Transynaptic signaling in which the ligand is carried across the synapse by an exosome. GOC:dos PMID:19837038 Any process that modulates the frequency, rate or extent of transport or maintenance of location of a postsynaptic recycling endosome within the postsynapse. dos 2017-08-25T15:37:50Z biological_process GO:0099158 regulation of recycling endosome localization within postsynapse Any process that modulates the frequency, rate or extent of transport or maintenance of location of a postsynaptic recycling endosome within the postsynapse. GOC:dos PMID:20098723 Any process that modulates the frequency, rate or extent of modification of postsynaptic structure. dos 2017-08-25T15:47:55Z regulation of postsynapse remodelling biological_process GO:0099159 regulation of modification of postsynaptic structure Any process that modulates the frequency, rate or extent of modification of postsynaptic structure. GOC:dos The intermediate filament cytoskeleton that is part of a postsynapse dos 2017-08-28T15:26:08Z cellular_component GO:0099160 postsynaptic intermediate filament cytoskeleton The intermediate filament cytoskeleton that is part of a postsynapse GOC:dos PMID:25869803 Any process that modulates the frequency, rate or extent of presynaptic dense core granule exocytosis. dos 2017-09-10T10:59:08Z regulation of presynaptic dense core vesicle exocytosis biological_process GO:0099161 regulation of presynaptic dense core granule exocytosis Any process that modulates the frequency, rate or extent of presynaptic dense core granule exocytosis. GOC:dos PMID:17881523 regulation of presynaptic dense core vesicle exocytosis Any process that modulates the frequency, rate or extent of neurotransmitter loading into synaptic vesicles. dos 2017-09-10T11:07:57Z regulation of neurotransmitter uptake into synaptic vesicle regulation of synaptic vesicle neurotransmitter loading biological_process GO:0099162 regulation of neurotransmitter loading into synaptic vesicle Any process that modulates the frequency, rate or extent of neurotransmitter loading into synaptic vesicles. GOC:dos PMID:25176177 regulation of neurotransmitter uptake into synaptic vesicle PMID:15217342 regulation of synaptic vesicle neurotransmitter loading Cell-cell signaling to or from a synapse, mediated by nitric oxide. biological_process GO:0099163 synaptic signaling by nitric oxide Cell-cell signaling to or from a synapse, mediated by nitric oxide. GOC:dos PMID:19038221 The membrane component of the postsynaptic specialization of a symmetic synapse. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. dos 2017-09-10T11:50:44Z cellular_component GO:0099164 postsynaptic specialization membrane of symmetric synapse The membrane component of the postsynaptic specialization of a symmetic synapse. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. GOC:dos A network of proteins adjacent to the postsynaptic membrane of a symmetric synapse. Its major components include that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. This structure is not as thick or electron dense as the postsynaptic density found in asymmetric synapses. dos 2017-09-10T11:54:15Z cellular_component GO:0099165 postsynaptic specialization of symmetric synapse, intracellular component A network of proteins adjacent to the postsynaptic membrane of a symmetric synapse. Its major components include that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. This structure is not as thick or electron dense as the postsynaptic density found in asymmetric synapses. GOC:dos The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. dos 2017-09-10T11:56:47Z intrinsic to postsynaptic specialization membrane of symmetric synapse cellular_component GO:0099166 intrinsic component of postsynaptic specialization membrane of symmetric synapse The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. GOC:dos The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. dos 2017-09-10T11:58:46Z cellular_component GO:0099167 integral component of postsynaptic specialization membrane of symmetric synapse The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. GOC:dos The component of the postsynaptic specialization membrane of a symmetric synapse consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. dos 2017-09-10T12:00:26Z cellular_component GO:0099168 extrinsic component of postsynaptic specialization membrane of symmetric synapse The component of the postsynaptic specialization membrane of a symmetric synapse consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. GOC:dos The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. dos 2017-09-10T12:01:53Z cellular_component GO:0099169 anchored component of postsynaptic specialization membrane of symmetric synapse The component of the postsynaptic specialization membrane of a symmetric synapse consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping. GOC:dos Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission. dos 2017-09-11T17:09:17Z biological_process GO:0099170 postsynaptic modulation of chemical synaptic transmission Any process, acting in the postsynapse that results in modulation of chemical synaptic transmission. GOC:dos Any process, acting in the presynapse that results in modulation of chemical synaptic transmission. dos 2017-09-11T17:09:31Z biological_process GO:0099171 presynaptic modulation of chemical synaptic transmission Any process, acting in the presynapse that results in modulation of chemical synaptic transmission. GOC:dos A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse. presynapse development presynapse organisation biological_process presynapse morphogenesis presynapse organization and biogenesis GO:0099172 presynapse organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a presynapse. GOC:dos presynapse organisation GOC:curators presynapse morphogenesis GOC:BHF presynapse organization and biogenesis GOC:mah A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse. postsynapse development postsynapse organisation biological_process postsynapse morphogenesis postsynapse organization and biogenesis GO:0099173 postsynapse organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a postsynapse. GOC:dos postsynapse organisation GOC:curators postsynapse morphogenesis GOC:BHF postsynapse organization and biogenesis GOC:mah Any process that modulates the physical form of a presynapse. regulation of presynapse organisation regulation of presynapse structure biological_process regulation of presynapse organization and biogenesis GO:0099174 regulation of presynapse organization Any process that modulates the physical form of a presynapse. GOC:ai GOC:dph GOC:tb regulation of presynapse organisation GOC:mah regulation of presynapse organization and biogenesis GOC:mah Any process that modulates the physical form of a postsynapse. regulation of postsynapse organisation regulation of postsynapse structure biological_process regulation of postsynapse organization and biogenesis GO:0099175 regulation of postsynapse organization Any process that modulates the physical form of a postsynapse. GOC:ai GOC:dph GOC:tb regulation of postsynapse organisation GOC:mah regulation of postsynapse organization and biogenesis GOC:mah Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by a trans-synaptic complex. biological_process regulation of trans-synaptic complex mediated retrograde trans-synaptic signaling GO:0099176 regulation of retrograde trans-synaptic signaling by trans-synaptic protein complex Any process that modulates the frequency, rate or extent of retrograde trans-synaptic signaling by a trans-synaptic complex. GOC:dos PMID:23209303 regulation of trans-synaptic complex mediated retrograde trans-synaptic signaling GOC:bf Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes. regulation of synapse adhesion between pre- and post-synapse biological_process GO:0099179 regulation of synaptic membrane adhesion Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes. GOC:dos regulation of synapse adhesion between pre- and post-synapse syngo_official_label The directed movement of Zn2+ ions from the cytoplasm into the lumen of a cytoplasmic vesicle. Zn2+ import into synaptic vesicle zinc import into synaptic vesicle biological_process GO:0099180 zinc ion import into synaptic vesicle The directed movement of Zn2+ ions from the cytoplasm into the lumen of a cytoplasmic vesicle. PMID:9990090 The action of a molecule that contributes to the structural integrity of a presynapse. dos 2017-12-20T13:42:46Z molecular_function GO:0099181 structural constituent of presynapse The action of a molecule that contributes to the structural integrity of a presynapse. GOC:dos PMID:23751498 The intermediate filament cytoskeleton that is part of a presynapse. dos 2017-12-01T18:10:21Z cellular_component GO:0099182 presynaptic intermediate filament cytoskeleton The intermediate filament cytoskeleton that is part of a presynapse. GOC:dos Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of brain derived neurotrophic factor (BDNF), that modulates the synaptic transmission properties of the synapse. dos 2017-12-01T18:25:24Z biological_process GO:0099183 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. trans-synaptic signaling by BDNF, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of brain derived neurotrophic factor (BDNF), that modulates the synaptic transmission properties of the synapse. GOC:dos The action of a molecule that contributes to the structural integrity of a postsynaptic intermediate filament cytoskeleton. dos 2017-12-20T13:45:35Z molecular_function GO:0099184 structural constituent of postsynaptic intermediate filament cytoskeleton The action of a molecule that contributes to the structural integrity of a postsynaptic intermediate filament cytoskeleton. GOC:dos A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprised of intermediate filament and their associated proteins in the postsynaptic cytoskeleton. dos 2017-12-20T13:47:30Z biological_process GO:0099185 postsynaptic intermediate filament cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprised of intermediate filament and their associated proteins in the postsynaptic cytoskeleton. GOC:dos The action of a molecule that contributes to the structural integrity of a postsynapse. dos 2017-12-20T14:54:33Z molecular_function GO:0099186 structural constituent of postsynapse The action of a molecule that contributes to the structural integrity of a postsynapse. GOC:dos A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton. dos 2017-12-20T15:06:57Z biological_process GO:0099188 postsynaptic cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising cytoskeletal filaments and their associated proteins in the postsynaptic cytoskeleton. GOC:dos The portion of the spectrin-associated cytoskeleton contained within the postsynapse. dos 2017-12-20T15:29:09Z cellular_component GO:0099189 postsynaptic spectrin-associated cytoskeleton The portion of the spectrin-associated cytoskeleton contained within the postsynapse. GOC:dos PMID:28576936 A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of spectrin-associated cytoskeleton and associated proteins in the postsynapse. dos 2017-12-20T15:34:26Z biological_process GO:0099190 postsynaptic spectrin-associated cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of spectrin-associated cytoskeleton and associated proteins in the postsynapse. GOC:dos PMID:28576936 Cell-cell signaling between presynapse and postsynapse mediated by brain-derived neurotrophic factor (BDNF) crossing the synaptic cleft. dos 2017-12-20T15:48:33Z trans-synaptic signaling by brain-derived neurotrophic factor biological_process GO:0099191 trans-synaptic signaling by BDNF Cell-cell signaling between presynapse and postsynapse mediated by brain-derived neurotrophic factor (BDNF) crossing the synaptic cleft. GOC:dos A synapse formed by a cerebellar Golgi cell synapsing on to a cerebellar granule cell. dos 2017-12-20T16:12:25Z cellular_component GO:0099192 cerebellar Golgi cell to granule cell synapse A synapse formed by a cerebellar Golgi cell synapsing on to a cerebellar granule cell. PMID:26134650 The component of the synaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. dos 2017-05-25T17:23:21Z intrinsic to synaptic membrane cellular_component GO:0099240 intrinsic component of synaptic membrane The component of the synaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane. GOC:dos GOC:mah The component of the synaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. dos 2017-05-25T17:24:23Z cellular_component GO:0099243 extrinsic component of synaptic membrane The component of the synaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. GOC:dos The regulatory process by which increased cytosolic calcium levels lead to the the fusion of synaptic vesicles with the presynaptic active zone membrane by bringing primed synaptic vesicle membrane into contact with membrane presynaptic active zone membrane. biological_process GO:0099502 calcium-dependent activation of synaptic vesicle fusion The regulatory process by which increased cytosolic calcium levels lead to the the fusion of synaptic vesicles with the presynaptic active zone membrane by bringing primed synaptic vesicle membrane into contact with membrane presynaptic active zone membrane. PMID:23060190 A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters. biological_process GO:0099504 synaptic vesicle cycle A biological process in which synaptic vesicles are loaded with neurotransmitters, move to the active zone, exocytose and are then recycled via endocytosis, ultimately leading to reloading with neurotransmitters. PMID:15217342 Any process that modulates the potential difference across a presynaptic membrane. regulation of pre-synaptic membrane potential biological_process GO:0099505 regulation of presynaptic membrane potential Any process that modulates the potential difference across a presynaptic membrane. GOC:dph GOC:ef The directed movement of synaptic vesicles along actin filaments within a cell, powered by molecular motors. biological_process GO:0099506 synaptic vesicle transport along actin filament The directed movement of synaptic vesicles along actin filaments within a cell, powered by molecular motors. GOC:dos Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential. ligand gated ion channel activity involved in regulation of presynaptic membrane potential ligand-dependent ion channel activity involved in regulation of pre-synaptic membrane potential ligand-dependent ion channel activity involved in regulation of presynaptic membrane potential ligand-gated ion channel activity involved in regulation of pre-synaptic membrane potential molecular_function GO:0099507 ligand-gated ion channel activity involved in regulation of presynaptic membrane potential Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential. GOC:dos PMID:15145529 PMID:19558451 Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse. voltage gated ion channel activity involved in regulation of presynaptic membrane potential voltage-dependent ion channel activity involved in regulation of pre-synaptic membrane potential voltage-dependent ion channel activity involved in regulation of presynaptic membrane potential voltage-gated ion channel activity involved in regulation of pre-synaptic membrane potential molecular_function GO:0099508 voltage-gated ion channel activity involved in regulation of presynaptic membrane potential Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse. GOC:dos Any process that regulates the concentration of calcium in the presynaptic cytosol. regulation of presynaptic cytosolic calcium levels biological_process GO:0099509 regulation of presynaptic cytosolic calcium ion concentration Any process that regulates the concentration of calcium in the presynaptic cytosol. GOC:dos regulation of presynaptic cytosolic calcium levels Regulation of cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of a voltage-gated calcium ion channel. molecular_function GO:0099511 voltage-gated calcium channel activity involved in regulation of cytosolic calcium levels Regulation of cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of a voltage-gated calcium ion channel. GOC:dos The directed movement of synaptic vesicles along cytoskeletal fibers such as microfilaments or microtubules within a cell, powered by molecular motors. biological_process GO:0099514 synaptic vesicle cytoskeletal transport The directed movement of synaptic vesicles along cytoskeletal fibers such as microfilaments or microtubules within a cell, powered by molecular motors. GOC:dos The directed movement of synaptic vesicles along microtubules within a cell, powered by molecular motors. biological_process GO:0099517 synaptic vesicle transport along microtubule The directed movement of synaptic vesicles along microtubules within a cell, powered by molecular motors. GOC:dos Any ion antiporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential ion antiporter activity involved in regulation of pre-synaptic membrane potential molecular_function GO:0099520 ion antiporter activity involved in regulation of presynaptic membrane potential Any ion antiporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential GOC:dos Any ATPase coupled ion transmembrane transporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential. ATPase coupled ion transmembrane transporter activity involved in regulation of pre-synaptic membrane potential ATPase-coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential molecular_function GO:0099521 ATPase coupled ion transmembrane transporter activity involved in regulation of presynaptic membrane potential Any ATPase coupled ion transmembrane transporter activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential. GOC:dos PMID:17220883 The region of the cytosol consisting of all cytosol that is part of the presynapse. cellular_component GO:0099523 presynaptic cytosol The region of the cytosol consisting of all cytosol that is part of the presynapse. GOC:dos The region of the cytosol consisting of all cytosol that is part of the postsynapse. cellular_component GO:0099524 postsynaptic cytosol The region of the cytosol consisting of all cytosol that is part of the postsynapse. GOC:dos The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels. biological_process GO:0099525 presynaptic dense core vesicle exocytosis The secretion of molecules (e.g. neuropeptides and neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense in response to increased presynaptic cytosolic calcium levels. PMID:17553987 PMID:24653208 A series of molecular signals that conveys information from the presynapse to the nucleus via cytoskeletal transport of a protein from a presynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications). presynaptic signaling to nucleus biological_process GO:0099526 This class does not cover the cellular machinery (motor proteins, cargo-recognition proteins) that transports the signaling protein along the cytoskeleton towards the nucleus. For these cases, annotate to the appropriate transport/trafficking term. presynapse to nucleus signaling pathway A series of molecular signals that conveys information from the presynapse to the nucleus via cytoskeletal transport of a protein from a presynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications). GOC:dos PMID:24317321 PMID:25652077 A series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications). postsynaptic signaling to nucleus biological_process GO:0099527 postsynapse to nucleus signaling pathway A series of molecular signals that conveys information from the postsynapse to the nucleus via cytoskeletal transport of a protein from a postsynapse to the component to the nucleus where it affects biochemical processes that occur in the nucleus (e.g DNA transcription, mRNA splicing, or DNA/histone modifications). GOC:dos PMID:24317321 PMID:25652077 Neurotransmitter receptor activity occurring in the postsynaptic membrane that is involved in regulating postsynaptic membrane potential, either directly (ionotropic receptors) or indirectly (e.g. via GPCR activation of an ion channel.) molecular_function GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential Neurotransmitter receptor activity occurring in the postsynaptic membrane that is involved in regulating postsynaptic membrane potential, either directly (ionotropic receptors) or indirectly (e.g. via GPCR activation of an ion channel.) GOC:dos A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane. G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential molecular_function GO:0099530 G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential A G protein-coupled receptor activity occurring in the postsynaptic membrane that is part of a GPCR signaling pathway that positively regulates ion channel activity in the postsynaptic membrane. GOC:dos The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission. biological_process GO:0099531 presynaptic process involved in chemical synaptic transmission The pathway leading to secretion of a neurotransmitter from the presynapse as part of synaptic transmission. GOC:dos The process in which synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles. synaptic vesicle processing via endosome biological_process GO:0099532 This covers processing of synaptic vesicles trafficked to synapse as well as of endocytosed vesicles as part of recycling. It is there for not part of the synaptic vesicle cycle. synaptic vesicle endosomal processing The process in which synaptic vesicles fuse to the presynaptic endosome followed by sorting of synaptic vesicle components and budding of new synaptic vesicles. GOC:dos Any process that increases the concentration of calcium ions in the presynaptic cytosol. biological_process GO:0099533 positive regulation of presynaptic cytosolic calcium concentration Any process that increases the concentration of calcium ions in the presynaptic cytosol. GOC:dos The directed change of presynaptic cytosolic free calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in presynaptic cytosolic calcium concentrations. calcium ion binding involved in regulation of presynaptic cytosolic calcium levels presynaptic calcium ion buffering regulation of presynaptic cytosolic calcium ion concentration by calcium ion buffering molecular_function GO:0099534 calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration The directed change of presynaptic cytosolic free calcium ion concentration in the cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in presynaptic cytosolic calcium concentrations. PMID:24442513 PMID:26190970 calcium ion binding involved in regulation of presynaptic cytosolic calcium levels The extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft. extra-synaptic extracellular matrix cellular_component GO:0099535 synapse-associated extracellular matrix The extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft. GOC:dos Cell-cell signaling to, from or or within a synapse. biological_process GO:0099536 synaptic signaling Cell-cell signaling to, from or or within a synapse. GOC:dos Cell-cell signaling in either direction across the synaptic cleft. biological_process GO:0099537 trans-synaptic signaling Cell-cell signaling in either direction across the synaptic cleft. GOC:dos Cell-cell signaling to or from a synapse, mediated by a peptide. biological_process GO:0099538 synaptic signaling via neuropeptide Cell-cell signaling to or from a synapse, mediated by a peptide. GOC:dos The secretion of neuropeptides contained within a dense core vesicle by fusion of the granule with the presynaptic membrane, stimulated by a rise in cytosolic calcium ion concentration. neuropeptide secretion from presynapse via dense core granule exocytosis biological_process GO:0099539 neuropeptide secretion from presynapse The secretion of neuropeptides contained within a dense core vesicle by fusion of the granule with the presynaptic membrane, stimulated by a rise in cytosolic calcium ion concentration. PMID:17553987 PMID:24653208 Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft. biological_process GO:0099540 trans-synaptic signaling by neuropeptide Cell-cell signaling between presynapse and postsynapse mediated by a peptide ligand crossing the synaptic cleft. GOC:dos Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid. biological_process GO:0099541 trans-synaptic signaling by lipid Cell-cell signaling from post to pre-synapse, across the synaptic cleft, mediated by a lipid. GOC:dos Cell-cell signaling in either direction across the synaptic cleft, mediated by an endocannabinoid ligand. biological_process GO:0099542 trans-synaptic signaling by endocannabinoid Cell-cell signaling in either direction across the synaptic cleft, mediated by an endocannabinoid ligand. GOC:dos Cell-cell signaling between presynapse and postsynapse mediated by a soluble gas ligand crossing the synaptic cleft. biological_process GO:0099543 trans-synaptic signaling by soluble gas Cell-cell signaling between presynapse and postsynapse mediated by a soluble gas ligand crossing the synaptic cleft. GOC:dos The extracellular region immediately adjacent to to a synapse. extrasynaptic space cellular_component GO:0099544 perisynaptic space The extracellular region immediately adjacent to to a synapse. GOC:dos extrasynaptic space Cell-cell signaling between presynapse and postsynapse mediated by a trans-synaptic protein complex. biological_process GO:0099545 trans-synaptic signaling by trans-synaptic complex Cell-cell signaling between presynapse and postsynapse mediated by a trans-synaptic protein complex. GOC:dos Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission. biological_process GO:0099546 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. protein catabolic process, modulating synaptic transmission Any protein degradation process, occurring at a presynapse, that regulates synaptic transmission. GOC:dos PMID:23083742 Any process that modulates synaptic transmission by regulating translation occurring at the synapse. biological_process GO:0099547 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. regulation of translation at synapse, modulating synaptic transmission Any process that modulates synaptic transmission by regulating translation occurring at the synapse. GOC:dos Cell-cell signaling between presynapse and postsynapse mediated by nitric oxide. biological_process GO:0099548 trans-synaptic signaling by nitric oxide Cell-cell signaling between presynapse and postsynapse mediated by nitric oxide. GOC:dos Cell-cell signaling between presynapse and postsynapse mediated by carbon monoxide. biological_process GO:0099549 trans-synaptic signaling by carbon monoxide Cell-cell signaling between presynapse and postsynapse mediated by carbon monoxide. GOC:dos Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse. biological_process GO:0099550 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. trans-synaptic signaling, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, across the synaptic cleft, that modulates the synaptic transmission properties of the synapse. GOC:dos Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse. biological_process GO:0099551 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. trans-synaptic signaling by neuropeptide, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the vesicular release and reception of neuropeptide molecules, that modulates the synaptic transmission properties of the synapse. GOC:dos Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse. biological_process GO:0099552 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. trans-synaptic signaling by lipid, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the release and reception of lipid molecules, that modulates the synaptic transmission properties of the synapse. GOC:dos PMID:21531987 Cell-cell signaling between presynapse and postsynapse, via the release and reception of endocannabinoid ligands, that modulates the synaptic transmission properties of the synapse. biological_process GO:0099553 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. trans-synaptic signaling by endocannabinoid, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the release and reception of endocannabinoid ligands, that modulates the synaptic transmission properties of the synapse. GOC:dos PMID:21531987 Cell-cell signaling between presynapse and postsynapse, via the release and reception of gaseous molecules, that modulates the synaptic transmission properties of the synapse. biological_process GO:0099554 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. trans-synaptic signaling by soluble gas, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the release and reception of gaseous molecules, that modulates the synaptic transmission properties of the synapse. GOC:dos Cell-cell signaling between presynapse and postsynapse, via the release and reception of nitric oxide molecules, that modulates the synaptic transmission properties of the synapse. biological_process GO:0099555 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. trans-synaptic signaling by nitric oxide, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the release and reception of nitric oxide molecules, that modulates the synaptic transmission properties of the synapse. GOC:dos Cell-cell signaling between presynapse and postsynapse, via the release and reception of carbon monoxide molecules, that modulates the synaptic transmission properties of the synapse. biological_process GO:0099556 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. trans-synaptic signaling by carbon monoxide, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, via the release and reception of carbon monoxide molecules, that modulates the synaptic transmission properties of the synapse. GOC:dos Cell-cell signaling between presynapse and postsynapse, mediated by transynaptic protein complexes, that modulates the synaptic transmission properties of the synapse. biological_process GO:0099557 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission Cell-cell signaling between presynapse and postsynapse, mediated by transynaptic protein complexes, that modulates the synaptic transmission properties of the synapse. GOC:dos PMID:19029886 A process that preserves the structural organistation and orientation of a synaptic cellular component such as the synaptic cytoskeleton and molecular scaffolds. synaptic maintenance biological_process GO:0099558 maintenance of synapse structure A process that preserves the structural organistation and orientation of a synaptic cellular component such as the synaptic cytoskeleton and molecular scaffolds. GOC:dos PMID:24449494 PMID:25611509 The process by which alignment between postsynaptic density and presynaptic active zone is maintained. biological_process GO:0099559 maintenance of alignment of postsynaptic density and presynaptic active zone The process by which alignment between postsynaptic density and presynaptic active zone is maintained. GOC:dos The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane. synapse adhesion between pre- and post-synapse biological_process GO:0099560 synaptic membrane adhesion The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane. GOC:dos synapse adhesion between pre- and post-synapse The binding of a synaptic membrane to the extracellular matrix via adhesion molecules. biological_process GO:0099561 synaptic membrane adhesion to extracellular matrix The binding of a synaptic membrane to the extracellular matrix via adhesion molecules. GOC:dos A process which maintains the organization and the arrangement of proteins in the presynaptic density. biological_process GO:0099562 maintenance of postsynaptic density structure A process which maintains the organization and the arrangement of proteins in the presynaptic density. GOC:dos Any process that modifies the structure/morphology of a synapse. synapse remodelling biological_process GO:0099563 This class does not cover assembly or disassembly of synapses, only the modification/remodelling of existing ones. modification of synaptic structure Any process that modifies the structure/morphology of a synapse. GOC:dos Any process that modulates synaptic transmission via modification of the structure of the synapse. biological_process GO:0099564 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. modification of synaptic structure, modulating synaptic transmission Any process that modulates synaptic transmission via modification of the structure of the synapse. GOC:dos The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol. biological_process postsynaptic process involved in chemical synaptic transmission GO:0099565 chemical synaptic transmission, postsynaptic The part of synaptic transmission occurring in the post-synapse: a signal transduction pathway consisting of neurotransmitter receptor activation and its effects on postsynaptic membrane potential and the ionic composition of the postsynaptic cytosol. GOC:dos postsynaptic process involved in chemical synaptic transmission Any process that regulates the concentration of calcium in the postsynaptic cytosol. regulation of postsynaptic cytosolic calcium levels biological_process GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration Any process that regulates the concentration of calcium in the postsynaptic cytosol. GOC:dos regulation of postsynaptic cytosolic calcium levels The directed change of free calcium ion concentration in the postsynaptic cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in postsynaptic cytosolic calcium concentrations. calcium ion binding involved in regulation of postsynaptic cytosolic calcium levels postsynaptic calcium ion buffering molecular_function regulation of postsynaptic cytosolic calcium ion concentration by calcium ion buffering GO:0099567 calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration The directed change of free calcium ion concentration in the postsynaptic cytosol via the reversible binding of calcium ions to calcium-binding proteins in the cytosol thereby modulating the spatial and temporal dynamics of changes in postsynaptic cytosolic calcium concentrations. PMID:24442513 PMID:26190970 calcium ion binding involved in regulation of postsynaptic cytosolic calcium levels The portion of the cytoskeleton contained within the presynapse. cellular_component GO:0099569 presynaptic cytoskeleton The portion of the cytoskeleton contained within the presynapse. GOC:dos The portion of the cytoskeleton contained within the postsynapse. cellular_component GO:0099571 postsynaptic cytoskeleton The portion of the cytoskeleton contained within the postsynapse. GOC:dos PMID:19889835 A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. cellular_component GO:0099572 postsynaptic specialization A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. PMID:22046028 The post-synaptic specialization of a glutamatergic excitatory synapse. postsynaptic specialization, glutamatergic neuron-to-neuron synapse cellular_component GO:0099573 glutamatergic postsynaptic density The post-synaptic specialization of a glutamatergic excitatory synapse. GOC:dos postsynaptic specialization, glutamatergic neuron-to-neuron synapse Any process that modulates synaptic transmission by regulating protein degradation at the synapse. biological_process GO:0099574 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. regulation of protein catabolic process at synapse, modulating synaptic transmission Any process that modulates synaptic transmission by regulating protein degradation at the synapse. GOC:dos Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse. biological_process GO:0099575 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. regulation of protein catabolic process at presynapse, modulating synaptic transmission Any process that modulates synaptic transmission by regulating a catabolic process occurring at a presynapse. GOC:dos Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse. biological_process GO:0099576 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. regulation of protein catabolic process at postsynapse, modulating synaptic transmission Any process that modulates synaptic transmission by regulating a catabolic process occurring at a postsynapse. GOC:dos Any process that modulates synaptic transmission by regulating translation occurring at the presynapse. biological_process GO:0099577 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. regulation of translation at presynapse, modulating synaptic transmission Any process that modulates synaptic transmission by regulating translation occurring at the presynapse. GOC:dos Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse. biological_process GO:0099578 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. regulation of translation at postsynapse, modulating synaptic transmission Any process that modulates synaptic transmission by regulating translation occurring at the postsynapse. GOC:dos A G protein-coupled neurotransmitter receptor activity, occurring in the postsynaptic membrane, involved in regulation of postsynaptic membrane potential. G-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential molecular_function GO:0099579 G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential A G protein-coupled neurotransmitter receptor activity, occurring in the postsynaptic membrane, involved in regulation of postsynaptic membrane potential. GOC:dos Any ion antiporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential ion antiporter activity involved in regulation of post-synaptic membrane potential molecular_function GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential Any ion antiporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential GOC:dos Any ATPase coupled ion transmembrane transporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential. ATPase coupled ion transmembrane transporter activity involved in regulation of post-synaptic membrane potential ATPase-coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential molecular_function GO:0099581 ATPase coupled ion transmembrane transporter activity involved in regulation of postsynaptic membrane potential Any ATPase coupled ion transmembrane transporter activity, occurring in the postsynaptic membrane, that is involved in regulation of postsynaptic membrane potential. GOC:dos Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the presynaptic cytosol. neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium levels molecular_function GO:0099582 neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the presynaptic cytosol. GOC:dos neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium levels Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the postsynaptic cytosol. neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels molecular_function GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the postsynaptic cytosol. GOC:dos neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the presynaptic cytosol. biological_process GO:0099585 release of sequestered calcium ion into presynaptic cytosol The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the presynaptic cytosol. GOC:dos The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the postsynaptic cytosol. biological_process GO:0099586 release of sequestered calcium ion into postsynaptic cytosol The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the postsynaptic cytosol. GOC:dos Any process that increases the concentration of calcium ions in the postsynaptic cytosol. biological_process GO:0099588 positive regulation of postsynaptic cytosolic calcium concentration Any process that increases the concentration of calcium ions in the postsynaptic cytosol. GOC:dos Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors. biological_process GO:0099601 regulation of neurotransmitter receptor activity Any process that modulates the frequency, rate or extent of neurotransmitter receptor activity. Modulation may be via an effect on ligand affinity, or effector funtion such as ion selectivity or pore opening/closing in ionotropic receptors. GOC:dos Regulation of presynaptic cytosolic calcium ion concentrations via the action of voltage-gated calcium ion channels. voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels molecular_function GO:0099626 voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels Regulation of presynaptic cytosolic calcium ion concentrations via the action of voltage-gated calcium ion channels. GOC:dos PMID:15548655 voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels The process by which diffusing neurotransmitter receptor becomes trapped in region of the plasma membrane. biological_process GO:0099628 neurotransmitter receptor diffusion trapping The process by which diffusing neurotransmitter receptor becomes trapped in region of the plasma membrane. PMID:18832033 A network of proteins within and adjacent to the postsynaptic membrane of a symmetric synapse, consisting of anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components that spatially and functionally organize the neurotransmitter receptors at the synapse. This structure is not as thick or electron dense as the postsynaptic densities found in asymmetric synapses. postsynaptic density of inhibitory synapse cellular_component GO:0099629 postsynaptic specialization of symmetric synapse A network of proteins within and adjacent to the postsynaptic membrane of a symmetric synapse, consisting of anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components that spatially and functionally organize the neurotransmitter receptors at the synapse. This structure is not as thick or electron dense as the postsynaptic densities found in asymmetric synapses. PMID:18832033 postsynaptic density of inhibitory synapse PMID:18832033 The cytoplasmic component of the postsynaptic endocytic zone. postsynaptic endocytic zone cytoplasmic component cellular_component GO:0099631 postsynaptic endocytic zone cytoplasmic component The cytoplasmic component of the postsynaptic endocytic zone. GOC:dos The membrane component of the postsynaptic specialization. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. cellular_component GO:0099634 postsynaptic specialization membrane The membrane component of the postsynaptic specialization. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. GOC:dos Positive regulation of presynaptic cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of voltage-gated calcium ion channels. This is the first step in synaptic transmission molecular_function GO:0099635 voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels Positive regulation of presynaptic cytosolic calcium ion concentrations via the directed movement of calcium ions across the plasma-membrane into the cytosol via the action of voltage-gated calcium ion channels. This is the first step in synaptic transmission GOC:dos The directed movement of neurotransmitter receptors. biological_process GO:0099637 neurotransmitter receptor transport The directed movement of neurotransmitter receptors. GOC:dos The directed movement of neurotransmitter receptor from the endosome to the plasma membrane in transport vesicles. biological_process GO:0099639 neurotransmitter receptor transport, endosome to plasma membrane The directed movement of neurotransmitter receptor from the endosome to the plasma membrane in transport vesicles. GOC:dos The directed movement of proteins along microtubules in neuron projections. axonal protein transport biological_process GO:0099640 axo-dendritic protein transport The directed movement of proteins along microtubules in neuron projections. ISBN:0815316194 The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons. anterograde axon cargo transport biological_process GO:0099641 anterograde axonal protein transport The directed movement of proteins along microtubules from the cell body toward the cell periphery in nerve cell axons. GOC:dos The directed movement of proteins along microtubules from the cell periphery toward the cell body in nerve cell axons. retrograde axon cargo transport biological_process GO:0099642 retrograde axonal protein transport The directed movement of proteins along microtubules from the cell periphery toward the cell body in nerve cell axons. ISBN:0815316194 Any signal release from a synapse. biological_process GO:0099643 signal release from synapse Any signal release from a synapse. GOC:dos A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density). neurotransmitter receptor localisation in postsynaptic specialization membrane biological_process GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane A process in which a neurotransmitter is transported to, or maintained in, a location within the membrane adjacent to a postsynaptic specialization (e.g. postsynaptic density). GOC:dos neurotransmitter receptor localisation in postsynaptic specialization membrane GOC:TermGenie Vesicle-mediated transport of a neurotransmitter receptor vesicle from the plasma membrane to the endosome. biological_process GO:0099646 neurotransmitter receptor transport, plasma membrane to endosome Vesicle-mediated transport of a neurotransmitter receptor vesicle from the plasma membrane to the endosome. GOC:dos The component of the synaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. dos 2017-05-25T17:22:18Z cellular_component GO:0099699 integral component of synaptic membrane The component of the synaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. GOC:dos The induction of synaptic vesicle release by any process that leads to a rise in intracellular calcium ion concentration at the presynapse. This is the first step in synaptic transmission. biological_process GO:0099703 induction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration The induction of synaptic vesicle release by any process that leads to a rise in intracellular calcium ion concentration at the presynapse. This is the first step in synaptic transmission. GOC:dos ISBN:9780071120005 The directed movement of a neurotransmitter receptor complex along microtubules from the cell body toward the cell periphery in nerve cell axons. pg 2018-07-09T09:41:37Z biological_process GO:0140231 anterograde axonal transport of neurotransmitter receptor complex The directed movement of a neurotransmitter receptor complex along microtubules from the cell body toward the cell periphery in nerve cell axons. PMID:28680963 Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the presynaptic membrane potential. pg 2018-07-09T11:30:40Z intracellular cAMP activated cation channel activity involved in regulation of presynaptic membrane potential molecular_function GO:0140232 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. New term as requested here: https://github.com/geneontology/synapse/issues/231 intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the presynaptic membrane potential. PMID:21358644 Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the postsynaptic membrane potential. pg 2018-07-09T11:31:18Z intracellular cAMP activated cation channel activity involved in regulation of postsynaptic membrane potential molecular_function GO:0140233 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. New term as requested here: https://github.com/geneontology/synapse/issues/231 intracellular cAMP-activated cation channel activity involved in regulation of postsynaptic membrane potential Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts, to regulate the postsynaptic membrane potential. GOC:pvn A polyadenylation event (the enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule) that takes place at a postsynapse. pg 2018-07-13T12:03:28Z biological_process GO:0140235 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. RNA polyadenylation at postsynapse A polyadenylation event (the enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule) that takes place at a postsynapse. PMID:22727665 Translation that occurs at the presynapse. pg 2018-07-13T13:00:33Z biological_process GO:0140236 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/216 translation at presynapse Translation that occurs at the presynapse. PMID:27321671 Translation that occurs at the presynapse, and that modulates chemical synaptic transmission. pg 2018-07-13T13:07:23Z biological_process GO:0140237 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/216 translation at presynapse, modulating chemical synaptic transmission Translation that occurs at the presynapse, and that modulates chemical synaptic transmission. PMID:27321671 A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. pg 2018-07-15T07:33:55Z biological_process GO:0140238 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Term request: https://github.com/geneontology/synapse/issues/230 presynaptic endocytosis A vesicle-mediated transport process in which the presynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. PMID:24719103 A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. pg 2018-07-15T07:38:27Z biological_process GO:0140239 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Term request: https://github.com/geneontology/synapse/issues/230 postsynaptic endocytosis A vesicle-mediated transport process in which the postsynapse take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. PMID:12839988 A neuron to neuron synapse of a pyramidal neuron in the entorhinal cortex onto a granule cell in the dentate gyrus of the hippocampus. pg 2018-07-15T08:21:43Z perforant pathway to DG granule cell synapse cellular_component GO:0140240 New term request https://github.com/geneontology/synapse/issues/234 perforant pathway to dendrate granule cell synapse A neuron to neuron synapse of a pyramidal neuron in the entorhinal cortex onto a granule cell in the dentate gyrus of the hippocampus. PMID:22727665 PMID:29199135 Translation that occurs at the synapse. pg 2018-07-15T09:23:12Z biological_process GO:0140241 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/210. translation at synapse Translation that occurs at the synapse. PMID:23083742 Translation that occurs at the postsynapse. pg 2018-07-15T09:26:27Z biological_process GO:0140242 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/210. translation at postsynapse Translation that occurs at the postsynapse. PMID:20427644 Any process that regulates translation occurring at the synapse. pg 2018-07-15T09:38:26Z biological_process GO:0140243 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/210. regulation of translation at synapse Any process that regulates translation occurring at the synapse. PMID:20427644 Any process that regulates translation occurring at the presynapse. pg 2018-07-15T09:38:33Z biological_process GO:0140244 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/210. regulation of translation at presynapse Any process that regulates translation occurring at the presynapse. PMID:20427644 Any process that regulates translation occurring at the postsynapse. pg 2018-07-15T09:38:54Z biological_process GO:0140245 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/210. regulation of translation at postsynapse Any process that regulates translation occurring at the postsynapse. PMID:20427644 The chemical reactions and pathways resulting in the breakdown of a protein at a synapse. pg 2018-07-15T10:12:51Z biological_process GO:0140246 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/204. protein catabolic process at synapse The chemical reactions and pathways resulting in the breakdown of a protein at a synapse. PMID:17062563 The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse. pg 2018-07-15T10:23:49Z biological_process GO:0140247 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/204. protein catabolic process at presynapse The chemical reactions and pathways resulting in the breakdown of a protein at a presynapse. PMID:27764673 The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse. pg 2018-07-15T10:25:04Z biological_process GO:0140249 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/204. protein catabolic process at postsynapse The chemical reactions and pathways resulting in the breakdown of a protein at a postsynapse. PMID:17062563 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse. pg 2018-07-15T10:34:56Z biological_process GO:0140250 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/204. regulation protein catabolic process at synapse Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the synapse. PMID:23083742 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse. pg 2018-07-15T10:35:39Z biological_process GO:0140251 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/204. regulation protein catabolic process at presynapse Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the presynapse. PMID:27764673 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse. pg 2018-07-15T10:35:56Z biological_process GO:0140252 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. Discussion for term creation is here: https://github.com/geneontology/synapse/issues/204. regulation protein catabolic process at postsynapse Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein at the postsynapse. PMID:17062563 Any process that modulates the frequency, rate or extent of trans-synaptic signaling by BDNF, modulating synaptic transmission. BarbaraCzub 2018-04-17T13:56:34Z biological_process GO:0150035 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. regulation of trans-synaptic signaling by BDNF, modulating synaptic transmission Any process that modulates the frequency, rate or extent of trans-synaptic signaling by BDNF, modulating synaptic transmission. GOC:aruk GOC:bc PMID:19448629 Any process that modulates the frequency, rate or extent of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. BarbaraCzub 2018-04-18T09:54:49Z biological_process GO:0150036 Note that this term was created for the SynGO project, and will be obsoleted when the SynGO annotations are made in Noctua. regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission Any process that modulates the frequency, rate or extent of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. GOC:aruk GOC:bc PMID:27296803 Any process that modulates the frequency, rate or extent of calcium-dependent activation of synaptic vesicle fusion. BarbaraCzub 2018-04-18T12:47:38Z biological_process GO:0150037 regulation of calcium-dependent activation of synaptic vesicle fusion Any process that modulates the frequency, rate or extent of calcium-dependent activation of synaptic vesicle fusion. GOC:aruk GOC:bc PMID:27052163 The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a postsynaptic dense core vesicle by fusion of the granule with the plasma membrane of the postsynapse in response to increased cytosolic calcium levels. BarbaraCzub 2018-04-18T14:32:16Z biological_process GO:0150038 postsynaptic dense core vesicle exocytosis The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a postsynaptic dense core vesicle by fusion of the granule with the plasma membrane of the postsynapse in response to increased cytosolic calcium levels. GOC:aruk GOC:bc PMID:19448629 The action of a molecule that contributes to the structural integrity of the extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft. BarbaraCzub 2018-04-19T13:42:40Z extra-synaptic extracellular matrix structural constituent structural constituent of extra-synaptic extracellular matrix synapse-associated extracellular matrix structural constituent molecular_function GO:0150043 structural constituent of synapse-associated extracellular matrix The action of a molecule that contributes to the structural integrity of the extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft. GOC:aruk GOC:bc PMID:17189701 Any process that modulates the frequency, rate or extent of postsynaptic dense core vesicle exocytosis. BarbaraCzub 2018-04-20T13:34:32Z biological_process GO:0150044 regulation of postsynaptic dense core vesicle exocytosis Any process that modulates the frequency, rate or extent of postsynaptic dense core vesicle exocytosis. GOC:aruk GOC:bc PMID:19448629 Any process that modulates the frequency, rate or extent of synaptic signaling by nitric oxide. BarbaraCzub 2018-04-23T09:42:25Z biological_process GO:0150045 regulation of synaptic signaling by nitric oxide Any process that modulates the frequency, rate or extent of synaptic signaling by nitric oxide. GOC:aruk GOC:bc PMID:26311509 G protein-coupled neurotransmitter receptor activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. BarbaraCzub 2018-04-23T10:51:20Z G-protein coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential molecular_function GO:0150047 G protein-coupled neurotransmitter receptor activity involved in regulation of presynaptic membrane potential G protein-coupled neurotransmitter receptor activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. GOC:aruk GOC:bc PMID:11498050 A synapse of a granule cell fiber onto the dendrites of a Purkinje cell in cerebellum. BarbaraCzub 2018-04-23T14:44:40Z cerebellar parallel fiber to Purkinje cell synapse cellular_component GO:0150048 cerebellar granule cell to Purkinje cell synapse A synapse of a granule cell fiber onto the dendrites of a Purkinje cell in cerebellum. GOC:aruk GOC:bc PMID:12427822 The portion of the septin cytoskeleton contained within the postsynapse. BarbaraCzub 2018-04-26T14:45:52Z cellular_component GO:0150050 postsynaptic septin cytoskeleton The portion of the septin cytoskeleton contained within the postsynapse. GOC:aruk GOC:bc PMID:28065648 The network of the Golgi apparatus structures located within the postsynapse. BarbaraCzub 2018-05-08T15:42:56Z cellular_component Golgi outpost GO:0150051 postsynaptic Golgi apparatus The network of the Golgi apparatus structures located within the postsynapse. GOC:aruk GOC:bc PMID:23838184 Golgi outpost GOC:aruk GOC:bc PMID:21215635 Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse. BarbaraCzub 2018-05-08T16:38:55Z biological_process GO:0150052 regulation of postsynapse assembly Any process that modulates the frequency, rate or extent of postsynapse assembly, the aggregation, arrangement and bonding together of a set of components to form a postsynapse. GOC:aruk GOC:bc PMID:16394100 PMID:16672654 PMID:28185854 A synapse of a climbing fiber onto the dendrites of a Purkinje cell in cerebellum. The climbing fiber originates from the inferior olivary nucleus of the medulla oblongata. BarbaraCzub 2018-05-09T09:57:20Z cerebellar climbing fibre to Purkinje cell synapse cellular_component GO:0150053 cerebellar climbing fiber to Purkinje cell synapse A synapse of a climbing fiber onto the dendrites of a Purkinje cell in cerebellum. The climbing fiber originates from the inferior olivary nucleus of the medulla oblongata. GOC:aruk GOC:bc PMID:19597563 PMID:23811844 PMID:5044254 Any process that modulates the frequency, rate or extent of postsynaptic neurotransmitter receptor diffusion trapping. BarbaraCzub 2018-05-10T14:26:59Z biological_process GO:0150054 regulation of postsynaptic neurotransmitter receptor diffusion trapping Any process that modulates the frequency, rate or extent of postsynaptic neurotransmitter receptor diffusion trapping. GOC:aruk GOC:bc PMID:20935643 Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis. rl 2012-03-28T01:40:26Z biological_process regulation of synaptic vesicle retrieval GO:1900242 regulation of synaptic vesicle endocytosis Any process that modulates the frequency, rate or extent of synaptic vesicle endocytosis. GOC:BHF GOC:TermGenie regulation of synaptic vesicle retrieval GOC:TermGenie Any process that modulates the frequency, rate or extent of synaptic vesicle lumen acidification. dsf 2012-10-26T16:09:24Z regulation of proton loading regulation of synaptic vesicle lumen pH reduction biological_process GO:1901546 regulation of synaptic vesicle lumen acidification Any process that modulates the frequency, rate or extent of synaptic vesicle lumen acidification. GOC:TermGenie regulation of proton loading regulation of synaptic vesicle lumen pH reduction GOC:TermGenie Any process that modulates the frequency, rate or extent of anterograde synaptic vesicle transport. kmv 2014-12-12T16:28:27Z biological_process GO:1903742 regulation of anterograde synaptic vesicle transport Any process that modulates the frequency, rate or extent of anterograde synaptic vesicle transport. GOC:TermGenie GOC:kmv GO_REF:0000058 pmid:25329901 Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential. dos 2015-06-10T18:02:07Z ionotropic neurotransmitter receptor activity involved in regulation of post-synaptic membrane potential ionotropic neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential molecular_function GO:1904315 transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential. GOC:TermGenie GO_REF:0000061 PMID:20200227 ionotropic neurotransmitter receptor activity involved in regulation of post-synaptic membrane potential GOC:TermGenie ionotropic neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential GOC:TermGenie Any voltage-gated ion channel activity that is involved in regulation of postsynaptic membrane potential. dos 2016-03-04T15:51:54Z voltage gated ion channel activity involved in regulation of post-synaptic membrane potential voltage gated ion channel activity involved in regulation of postsynaptic membrane potential voltage-dependent ion channel activity involved in regulation of post-synaptic membrane potential voltage-dependent ion channel activity involved in regulation of postsynaptic membrane potential voltage-gated ion channel activity involved in regulation of post-synaptic membrane potential molecular_function GO:1905030 voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential Any voltage-gated ion channel activity that is involved in regulation of postsynaptic membrane potential. GOC:TermGenie GO_REF:0000061 ISBN:9780071120005 voltage gated ion channel activity involved in regulation of post-synaptic membrane potential GOC:TermGenie voltage gated ion channel activity involved in regulation of postsynaptic membrane potential GOC:TermGenie voltage-dependent ion channel activity involved in regulation of post-synaptic membrane potential GOC:TermGenie voltage-dependent ion channel activity involved in regulation of postsynaptic membrane potential GOC:TermGenie voltage-gated ion channel activity involved in regulation of post-synaptic membrane potential GOC:TermGenie Any calcium-induced calcium release activity that is involved in regulation of presynaptic cytosolic calcium ion concentration. dos 2016-03-17T12:12:53Z calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium levels molecular_function GO:1905054 calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium ion concentration Any calcium-induced calcium release activity that is involved in regulation of presynaptic cytosolic calcium ion concentration. GOC:TermGenie GO_REF:0000061 PMID:15919193 PMID:23918386 calcium-induced calcium release activity involved in regulation of presynaptic cytosolic calcium levels Any calcium:cation antiporter activity that is involved in regulation of presynaptic cytosolic calcium ion concentration. dos 2016-03-17T14:35:35Z calcium ion antiporter activity involved in regulation of presynaptic cytosolic calcium levels molecular_function GO:1905055 calcium:cation antiporter activity involved in regulation of presynaptic cytosolic calcium ion concentration Any calcium:cation antiporter activity that is involved in regulation of presynaptic cytosolic calcium ion concentration. GOC:TermGenie GO_REF:0000061 PMID:22972962 PMID:23255722 calcium ion antiporter activity involved in regulation of presynaptic cytosolic calcium levels Any calcium-transporting ATPase activity that is involved in regulation of presynaptic cytosolic calcium ion concentration. dos 2016-03-17T14:35:25Z ATP phosphohydrolase (Ca2+-transporting) involved in regulation of presynaptic cytosolic calcium ion concentration ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of presynaptic cytosolic calcium levels Ca(2+)-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration Ca2+-pumping ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration Ca2+-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration calcium transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration calcium ABC transporter involved in regulation of presynaptic cytosolic calcium ion concentration calcium efflux ATPase involved in regulation of presynaptic cytosolic calcium ion concentration calcium-translocating P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration plasma membrane Ca-ATPase involved in regulation of presynaptic cytosolic calcium ion concentration molecular_function GO:1905056 calcium-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration Any calcium-transporting ATPase activity that is involved in regulation of presynaptic cytosolic calcium ion concentration. GOC:TermGenie GO_REF:0000061 PMID:22972962 ATP phosphohydrolase (Ca2+-transporting) involved in regulation of presynaptic cytosolic calcium ion concentration GOC:TermGenie ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of presynaptic cytosolic calcium levels Ca(2+)-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration GOC:TermGenie Ca2+-pumping ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration GOC:TermGenie Ca2+-transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration GOC:TermGenie calcium transporting ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration GOC:TermGenie calcium ABC transporter involved in regulation of presynaptic cytosolic calcium ion concentration GOC:TermGenie calcium efflux ATPase involved in regulation of presynaptic cytosolic calcium ion concentration GOC:TermGenie calcium-translocating P-type ATPase activity involved in regulation of presynaptic cytosolic calcium ion concentration GOC:TermGenie plasma membrane Ca-ATPase involved in regulation of presynaptic cytosolic calcium ion concentration GOC:TermGenie Any voltage-gated calcium channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration. dos 2016-03-18T12:31:48Z depolarization-activated voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration depolarization-activated voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration depolarization-activated voltage-gated calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration voltage-dependent calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels voltage-gated calcium ion channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration voltage-sensitive calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration dihydropyridine-sensitive calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration molecular_function GO:1905057 voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels Any voltage-gated calcium channel activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration. GOC:TermGenie GO_REF:0000061 PMID:20734177 depolarization-activated voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration GOC:TermGenie depolarization-activated voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration GOC:TermGenie depolarization-activated voltage-gated calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration GOC:TermGenie voltage gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration GOC:TermGenie voltage-dependent calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration GOC:TermGenie voltage-gated calcium channel activity involved in regulation of postsynaptic cytosolic calcium levels voltage-gated calcium ion channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration GOC:TermGenie voltage-sensitive calcium channel involved in regulation of postsynaptic cytosolic calcium ion concentration GOC:TermGenie dihydropyridine-sensitive calcium channel activity involved in regulation of postsynaptic cytosolic calcium ion concentration GOC:TermGenie Any calcium-induced calcium release activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration. dos 2016-03-18T12:31:59Z calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium levels molecular_function GO:1905058 calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium ion concentration Any calcium-induced calcium release activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration. GOC:TermGenie GO_REF:0000061 PMID:23639769 calcium-induced calcium release activity involved in regulation of postsynaptic cytosolic calcium levels Any calcium-transporting ATPase activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration. dos 2016-03-18T12:32:08Z ATP phosphohydrolase (Ca2+-transporting) involved in regulation of postsynaptic cytosolic calcium ion concentration ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of postsynaptic cytosolic calcium levels Ca(2+)-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration Ca2+-pumping ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration Ca2+-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration calcium transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium levels calcium ABC transporter involved in regulation of postsynaptic cytosolic calcium ion concentration calcium efflux ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration calcium-translocating P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration plasma membrane Ca-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration sarco(endo)plasmic reticulum Ca2+-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration sarcoplasmic reticulum ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration molecular_function GO:1905059 calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration Any calcium-transporting ATPase activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration. GOC:TermGenie GO_REF:0000061 PMID:20678993 ATP phosphohydrolase (Ca2+-transporting) involved in regulation of postsynaptic cytosolic calcium ion concentration GOC:TermGenie ATPase-coupled calcium ion transmembrane transporter activity involved in regulation of postsynaptic cytosolic calcium levels Ca(2+)-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration GOC:TermGenie Ca2+-pumping ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration GOC:TermGenie Ca2+-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration GOC:TermGenie calcium transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration GOC:TermGenie calcium-transporting ATPase activity involved in regulation of postsynaptic cytosolic calcium levels calcium ABC transporter involved in regulation of postsynaptic cytosolic calcium ion concentration GOC:TermGenie calcium efflux ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration GOC:TermGenie calcium-translocating P-type ATPase activity involved in regulation of postsynaptic cytosolic calcium ion concentration GOC:TermGenie plasma membrane Ca-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration GOC:TermGenie sarco(endo)plasmic reticulum Ca2+-ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration GOC:TermGenie sarcoplasmic reticulum ATPase involved in regulation of postsynaptic cytosolic calcium ion concentration GOC:TermGenie Any calcium:cation antiporter activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration. dos 2016-03-18T12:32:17Z calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion levels molecular_function GO:1905060 calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration Any calcium:cation antiporter activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration. GOC:TermGenie GO_REF:0000061 PMID:18024055 calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion levels Any process that modulates the frequency, rate or extent of modification of synaptic structure. dos 2016-06-09T09:43:40Z regulation of synapse remodelling biological_process GO:1905244 regulation of modification of synaptic structure Any process that modulates the frequency, rate or extent of modification of synaptic structure. GOC:TermGenie GO_REF:0000058 PMID:25164660 regulation of synapse remodelling GOC:TermGenie Any process that modulates the frequency, rate or extent of modification of postsynaptic actin cytoskeleton. dos 2016-06-16T22:34:25Z regulation of postsynaptic actin cytoskeleton remodelling biological_process GO:1905274 regulation of modification of postsynaptic actin cytoskeleton Any process that modulates the frequency, rate or extent of modification of postsynaptic actin cytoskeleton. GOC:TermGenie GO_REF:0000058 PMID:21068295 regulation of postsynaptic actin cytoskeleton remodelling GOC:TermGenie Any process that modulates the frequency, rate or extent of postsynapse to nucleus signaling pathway. dos 2016-10-07T17:03:38Z regulation of postsynaptic signaling to nucleus biological_process GO:1905539 regulation of postsynapse to nucleus signaling pathway Any process that modulates the frequency, rate or extent of postsynapse to nucleus signaling pathway. GOC:TermGenie GO_REF:0000058 ISBN:9780071120005 regulation of postsynaptic signaling to nucleus GOC:TermGenie Any process that modulates the frequency, rate or extent of presynapse assembly. bc 2016-10-27T16:08:13Z regulation of presynapse biogenesis regulation of presynaptic terminal assembly biological_process GO:1905606 regulation of presynapse assembly Any process that modulates the frequency, rate or extent of presynapse assembly. GOC:PARL GOC:TermGenie GOC:bc GO_REF:0000058 PMID:25533483 regulation of presynapse biogenesis GOC:TermGenie regulation of presynaptic terminal assembly GOC:TermGenie Any mitochondrial calcium uptake that is involved in negative regulation of presynaptic cytosolic calcium concentration. dosumis 2016-12-06T10:53:17Z calcium ion transmembrane import into mitochondrion involved in negative regulation of presynaptic cytosolic calcium concentration mitochondrial calcium uptake involved in negative regulation of presynaptic cytosolic calcium concentration biological_process GO:1905743 calcium import into the mitochondrion involved in negative regulation of presynaptic cytosolic calcium concentration Any mitochondrial calcium uptake that is involved in negative regulation of presynaptic cytosolic calcium concentration. GOC:TermGenie GO_REF:0000060 PMID:26644474 calcium ion transmembrane import into mitochondrion involved in negative regulation of presynaptic cytosolic calcium concentration GOC:TermGenie Any process that modulates the frequency, rate or extent of synapse pruning. tberardini 2017-01-11T22:03:15Z regulation of synapse clearance regulation of synapse disassembly regulation of synapse elimination regulation of synapse removal biological_process GO:1905806 regulation of synapse pruning Any process that modulates the frequency, rate or extent of synapse pruning. GOC:TermGenie GO_REF:0000058 PMID:27779093 regulation of synapse disassembly The directed movement of substances in neuronal dense core vesicles along axonal microtubules towards the presynapse. anterograde dense core granule trafficking anterograde dense core granule transport biological_process GO:1990048 anterograde neuronal dense core vesicle transport The directed movement of substances in neuronal dense core vesicles along axonal microtubules towards the presynapse. GOC:kmv PMID:23358451 The directed movement of neuronal dense core vesicles along axonal microtubules towards the cell body. pr 2013-02-19T13:31:44Z retrograde dense core granule trafficking retrograde dense core granule transport biological_process GO:1990049 retrograde neuronal dense core vesicle transport The directed movement of neuronal dense core vesicles along axonal microtubules towards the cell body. GOC:kmv PMID:23358451 PMID:24762653 Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis. dph 2011-01-03T08:20:40Z biological_process GO:2000300 regulation of synaptic vesicle exocytosis Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis. GOC:obol