Adenylate_cyclase_activating_pathway	GO:0007189	activation of adenylate cyclase activity by G-protein signaling pathway	adenylate_cyclase_activity_of_G_alpha_olf_GTP_Adenylate_cyclase__active__complex__plasma_membrane_	GO:0004016	adenylate cyclase activity	Adenylaye_cyclase_increases_the_GTPase_activity_of_G_alpha_olf	GO:0003924	GTPase activity
Adenylate_cyclase_activating_pathway	GO:0007189	activation of adenylate cyclase activity by G-protein signaling pathway	adenylate_cyclase_binding_activity_of_Adenylate_cyclase__Mg2__cofactor___plasma_membrane_	GO:0008179	adenylate cyclase binding	Adenylate_cyclase_converts_ATP_into_cyclic_AMP	GO:0004016	adenylate cyclase activity
Adenylate_cyclase_inhibitory_pathway	GO:0007193	inhibition of adenylate cyclase activity by G-protein signaling pathway	GTPase_activity_of_Gi_alpha1_GTP_Adenylate_cyclase_G_alpha_olf_GTP_complex__plasma_membrane_	GO:0003924	GTPase activity	Adenylate_cyclase_increases_the_GTPase_activity_of_Gi_alpha	GO:0003924	GTPase activity
EGFR_downregulation	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	protein_tyrosine_kinase_activity_of_EGF_Phospho_EGFR__Y1045__dimer_CBL_GRB2__plasma_membrane_	GO:0004713	protein tyrosine kinase activity	Ubiquitination_of_stimulated_EGFR__Cbl_Grb2_	GO:0004842	ubiquitin-protein ligase activity
EGFR_downregulation	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	protein_tyrosine_kinase_activity_of_EGF_Phospho_EGFR__Y1045__dimer_CBL__plasma_membrane_	GO:0004713	protein tyrosine kinase activity	Cbl_binds_and_ubiquitinates_Phospho_Sprouty	GO:0004842	ubiquitin-protein ligase activity
EGFR_downregulation	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway	protein_tyrosine_kinase_activity_of_EGF_Phospho_EGFR__Y1045__dimer_CBL__plasma_membrane_	GO:0004713	protein tyrosine kinase activity	Ubiquitination_of_stimulated_EGFR__Cbl_	GO:0004842	ubiquitin-protein ligase activity
Frs2_mediated_activation	GO:0007242	intracellular signaling cascade	guanyl_nucleotide_exchange_factor_activity_of_Active_TrkA_receptor_Phospho_Frs2_CrkL_C3G_complex__endosome_	GO:0005085	guanyl-nucleotide exchange factor activity	_Frs2_Rap1_GTP_binds_to_and_activates_B_Raf	GO:0004672	protein kinase activity
Innate_Immunity_Signaling	GO:0045087	innate immune response	kinase_activity_of_IRAK4_MyD88_Mal_activated_TLR_receptor__plasma_membrane_	GO:0016301	kinase activity	Second_phosphorylation_of_IRAK1_by_IRAK4_bound_to_activated_TLR	GO:0016301	kinase activity
Innate_Immunity_Signaling	GO:0045087	innate immune response	kinase_activity_of_IRAK4_MyD88_Mal_activated_TLR_receptor__plasma_membrane_1	GO:0016301	kinase activity	Multiple_IRAK1_autophosphorylation_steps	GO:0016301	kinase activity
Innate_Immunity_Signaling	GO:0045087	innate immune response	protein_kinase_activity_of_Activated_TRAF6_Phospho_TAK1_TAB1_Phospho_Tab2_Complex__cytosol_1	GO:0004672	protein kinase activity	Phosphorylated_MAPK1_phosphorylates_ATF_2	GO:0004672	protein kinase activity
Innate_Immunity_Signaling	GO:0045087	innate immune response	protein_kinase_activity_of_Activated_TRAF6_Phospho_TAK1_TAB1_Phospho_Tab2_Complex__cytosol_2	GO:0004672	protein kinase activity	Phospho_IKK_Complex_phosphorylates_IkB_within_the_IkB_NFkB_Complex	GO:0004672	protein kinase activity
Innate_Immunity_Signaling	GO:0045087	innate immune response	protein_kinase_activity_of_RIP1__cytosol_	GO:0004672	protein kinase activity	Phospho_IKK_Complex_phosphorylates_IkB_within_the_IkB_NFkB_Complex	GO:0004672	protein kinase activity
Innate_Immunity_Signaling	GO:0045087	innate immune response	serine_type_endopeptidase_activity_of_Antigen__antibody__C1__activated_C1R__complex__plasma_membrane_	GO:0004252	serine-type endopeptidase activity	Conversion_of_C4_into_C4a_and_C4b	GO:0004252	serine-type endopeptidase activity
Innate_Immunity_Signaling	GO:0045087	innate immune response	serine_type_endopeptidase_activity_of_Antigen__antibody__C1_complex__plasma_membrane_	GO:0004252	serine-type endopeptidase activity	Activation_of_C1S	GO:0004252	serine-type endopeptidase activity
Innate_Immunity_Signaling	GO:0045087	innate immune response	serine_type_endopeptidase_activity_of_C3b_Factor_Bb_Properdin_complex__plasma_membrane_	GO:0004252	serine-type endopeptidase activity	Activation_of_C5	GO:0004252	serine-type endopeptidase activity
Innate_Immunity_Signaling	GO:0045087	innate immune response	serine_type_endopeptidase_activity_of_Complement_factor_D_precursor___extracellular_region_	GO:0004252	serine-type endopeptidase activity	C3_H2O__Factor_Bb_mediated_C3_cleavage_leads_to_C3b_deposition_on_a_target_cell_surface	GO:0004252	serine-type endopeptidase activity
Innate_Immunity_Signaling	GO:0045087	innate immune response	serine_type_endopeptidase_activity_of_Complement_factor_D_precursor___extracellular_region_	GO:0004252	serine-type endopeptidase activity	Cleavage_of_C3_by_C3_convertase	GO:0004252	serine-type endopeptidase activity
PI3K_AKT_signalling	GO:0048015	phosphoinositide-mediated signaling	_1_phosphatidylinositol_3_kinase_activity_of_Phospho_IRS1_2_PI3K_p85_p110___plasma_membrane_	GO:0016303	1-phosphatidylinositol-3-kinase activity	PTEN_dephosphorylates_PIP3	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
PI3K_AKT_signalling	GO:0048015	phosphoinositide-mediated signaling	phosphatidylinositol_3_4_5_trisphosphate_3_phosphatase_activity_of_PTEN__Mg2__cofactor___cytosol_1	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	PI3K_produces_PIP3_and_other_phosphatidyl_inositides	GO:0016303	1-phosphatidylinositol-3-kinase activity
PI3K_AKT_signalling	GO:0048015	phosphoinositide-mediated signaling	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_BAD	GO:0004674	protein serine/threonine kinase activity
PI3K_AKT_signalling	GO:0048015	phosphoinositide-mediated signaling	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_GSK3	GO:0004674	protein serine/threonine kinase activity
PI3K_AKT_signalling	GO:0048015	phosphoinositide-mediated signaling	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_IKKalpha	GO:0004674	protein serine/threonine kinase activity
PI3K_AKT_signalling	GO:0048015	phosphoinositide-mediated signaling	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_MDM2	GO:0004674	protein serine/threonine kinase activity
PI3K_AKT_signalling	GO:0048015	phosphoinositide-mediated signaling	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_PRAS40	GO:0004674	protein serine/threonine kinase activity
PI3K_AKT_signalling	GO:0048015	phosphoinositide-mediated signaling	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates__TSC2__inhibiting_it	GO:0004674	protein serine/threonine kinase activity
PI3K_AKT_signalling	GO:0048015	phosphoinositide-mediated signaling	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_caspase_9	GO:0004674	protein serine/threonine kinase activity
PI3K_AKT_signalling	GO:0048015	phosphoinositide-mediated signaling	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_p21Cip1_and_p27Kip1	GO:0004674	protein serine/threonine kinase activity
PI3K_AKT_signalling	GO:0048015	phosphoinositide-mediated signaling	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	TORC2__mTOR__phosphorylates_AKT_at_S473	GO:0004674	protein serine/threonine kinase activity
PI3K_AKT_signalling	GO:0048015	phosphoinositide-mediated signaling	protein_serine_threonine_kinase_activity_of_TORC2_complex__cytosol_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_BAD	GO:0004674	protein serine/threonine kinase activity
PI3K_AKT_signalling	GO:0048015	phosphoinositide-mediated signaling	protein_serine_threonine_kinase_activity_of_TORC2_complex__cytosol_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_GSK3	GO:0004674	protein serine/threonine kinase activity
PI3K_AKT_signalling	GO:0048015	phosphoinositide-mediated signaling	protein_serine_threonine_kinase_activity_of_TORC2_complex__cytosol_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_IKKalpha	GO:0004674	protein serine/threonine kinase activity
PI3K_AKT_signalling	GO:0048015	phosphoinositide-mediated signaling	protein_serine_threonine_kinase_activity_of_TORC2_complex__cytosol_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_MDM2	GO:0004674	protein serine/threonine kinase activity
PI3K_AKT_signalling	GO:0048015	phosphoinositide-mediated signaling	protein_serine_threonine_kinase_activity_of_TORC2_complex__cytosol_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_PRAS40	GO:0004674	protein serine/threonine kinase activity
PI3K_AKT_signalling	GO:0048015	phosphoinositide-mediated signaling	protein_serine_threonine_kinase_activity_of_TORC2_complex__cytosol_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates__TSC2__inhibiting_it	GO:0004674	protein serine/threonine kinase activity
PI3K_AKT_signalling	GO:0048015	phosphoinositide-mediated signaling	protein_serine_threonine_kinase_activity_of_TORC2_complex__cytosol_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_caspase_9	GO:0004674	protein serine/threonine kinase activity
PI3K_AKT_signalling	GO:0048015	phosphoinositide-mediated signaling	protein_serine_threonine_kinase_activity_of_TORC2_complex__cytosol_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_p21Cip1_and_p27Kip1	GO:0004674	protein serine/threonine kinase activity
Retrograde_neurotrophin_signalling	GO:0007242	intracellular signaling cascade	GTPase_activity_of_Dynamin_1__plasma_membrane_	GO:0003924	GTPase activity	Axonal_transport_of_NGF_Trk_complexes	GO:0003777	microtubule motor activity
Retrograde_neurotrophin_signalling	GO:0007242	intracellular signaling cascade	GTPase_activity_of_Dynamin_1__plasma_membrane_	GO:0003924	GTPase activity	Axonal_transport_of_NGF_Trk_complexes	GO:0007018	microtubule-based movement
Signaling_by_BMP	GO:0030509	BMP signaling pathway	transforming_growth_factor_beta_receptor_binding_activity_of_Dimeric_BMP2__extracellular_region_	GO:0005160	transforming growth factor beta receptor binding	Type_II_receptor_phosphorylates_type_I_receptor	GO:0016362	activin receptor activity, type II
Signaling_by_EGFR	GO:0007173	epidermal growth factor receptor signaling pathway	non_membrane_spanning_protein_tyrosine_phosphatase_activity_of_SHP2_GRB2_Phospho_GAB1_EGF_Phospho_EGFR_dimer__plasma_membrane_2	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity	Sustained_activation_of_SRC_kinase_by_SHP2	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity
Signaling_by_EGFR	GO:0007173	epidermal growth factor receptor signaling pathway	protein_tyrosine_kinase_activity_of_EGF_Phospho_EGFR__Y1045__dimer_CBL_GRB2__plasma_membrane_	GO:0004713	protein tyrosine kinase activity	Ubiquitination_of_stimulated_EGFR__Cbl_Grb2_	GO:0004842	ubiquitin-protein ligase activity
Signaling_by_EGFR	GO:0007173	epidermal growth factor receptor signaling pathway	protein_tyrosine_kinase_activity_of_EGF_Phospho_EGFR__Y1045__dimer_CBL__plasma_membrane_	GO:0004713	protein tyrosine kinase activity	Cbl_binds_and_ubiquitinates_Phospho_Sprouty	GO:0004842	ubiquitin-protein ligase activity
Signaling_by_EGFR	GO:0007173	epidermal growth factor receptor signaling pathway	protein_tyrosine_kinase_activity_of_EGF_Phospho_EGFR__Y1045__dimer_CBL__plasma_membrane_	GO:0004713	protein tyrosine kinase activity	Ubiquitination_of_stimulated_EGFR__Cbl_	GO:0004842	ubiquitin-protein ligase activity
Signaling_by_Insulin_receptor	GO:0008286	insulin receptor signaling pathway	kinase_activity_of_Activated_mTORC1__cytosol_	GO:0016301	kinase activity	Phosphorylation_and_activation_of_eIF4B_by_activated_S6K1	GO:0016301	kinase activity
Signaling_by_Insulin_receptor	GO:0008286	insulin receptor signaling pathway	kinase_activity_of_Activated_mTORC1__cytosol_	GO:0016301	kinase activity	Phosphorylation_and_activation_of_eIF4G_by_activated_S6K1	GO:0016301	kinase activity
Signaling_by_Insulin_receptor	GO:0008286	insulin receptor signaling pathway	kinase_activity_of_Activated_mTORC1__cytosol_	GO:0016301	kinase activity	Phosphorylation_of_Ribosomal_protein_S6_by_activated_S6K1	GO:0016301	kinase activity
Signaling_by_Insulin_receptor	GO:0008286	insulin receptor signaling pathway	kinase_activity_of_PIP3_PDK_complex__plasma_membrane___plasma_membrane_	GO:0016301	kinase activity	Phosphorylation_of_PDE3B	GO:0016301	kinase activity
Signaling_by_Insulin_receptor	GO:0008286	insulin receptor signaling pathway	kinase_activity_of_PIP3_PDK_complex__plasma_membrane___plasma_membrane_	GO:0016301	kinase activity	Phosphorylation_of_TSC2_by_PKB	GO:0016301	kinase activity
Signaling_by_Insulin_receptor	GO:0008286	insulin receptor signaling pathway	kinase_activity_of_PIP3_PDK_complex__plasma_membrane___plasma_membrane_	GO:0016301	kinase activity	Phosphorylation_of_complexed_TSC2_by_PKB	GO:0016301	kinase activity
Signaling_by_Insulin_receptor	GO:0008286	insulin receptor signaling pathway	kinase_activity_of_PIP3_Phosphorylated_PKB_complex__plasma_membrane_	GO:0016301	kinase activity	Hydrolysis_of_cAMP_to_5__AMP_by_Phosphorylated_PDE3B	GO:0016787	hydrolase activity
Signaling_by_Notch	GO:0007219	Notch signaling pathway	metallopeptidase_activity_of_ADAM_10_metalloprotease__Zn_cofactor___plasma_membrane_	GO:0008237	metallopeptidase activity	NEXT1_is_cleaved_to_produce_NICD1	GO:0004190	aspartic-type endopeptidase activity
Signaling_by_Notch	GO:0007219	Notch signaling pathway	metallopeptidase_activity_of_ADAM_10_metalloprotease__Zn_cofactor___plasma_membrane_1	GO:0008237	metallopeptidase activity	NEXT2_is_cleaved_to_produce_NICD2	GO:0004190	aspartic-type endopeptidase activity
Signaling_by_Notch	GO:0007219	Notch signaling pathway	metallopeptidase_activity_of_ADAM_10_metalloprotease__Zn_cofactor___plasma_membrane_2	GO:0008237	metallopeptidase activity	NEXT3_is_cleaved_to_produce_NICD3	GO:0004190	aspartic-type endopeptidase activity
Signaling_by_Notch	GO:0007219	Notch signaling pathway	metallopeptidase_activity_of_ADAM_10_metalloprotease__Zn_cofactor___plasma_membrane_3	GO:0008237	metallopeptidase activity	NEXT4_is_cleaved_to_produce_NICD4	GO:0004190	aspartic-type endopeptidase activity
Signaling_by_Rho_GTPases	GO:0007264	small GTPase mediated signal transduction	Rho_guanyl_nucleotide_exchange_factor_activity_of_GEF__cytosol_1	GO:0005089	Rho guanyl-nucleotide exchange factor activity	GAPs_inactivate_Rho_GTPase_GTP_by_hydrolysis	GO:0005096	GTPase activator activity
Signaling_by_TGF_beta	GO:0007179	transforming growth factor beta receptor signaling pathway	protein_binding_activity_of_Dimeric_TGF_beta1_type_II_receptor_complex__plasma_membrane_	GO:0005515	protein binding	Type_II_receptor_phosphorylates_type_I_receptor1	GO:0005026	transforming growth factor beta receptor activity, type II
Signaling_by_TGF_beta	GO:0007179	transforming growth factor beta receptor signaling pathway	protein_binding_activity_of_SARA__early_endosome_membrane_	GO:0005515	protein binding	Activated_type_I_receptor_phosphorylates_R_SMAD_directly	GO:0004675	transmembrane receptor protein serine/threonine kinase activity
Signaling_by_TGF_beta	GO:0007179	transforming growth factor beta receptor signaling pathway	transforming_growth_factor_beta_receptor_activity__type_II_of_TGF_beta_1_type_II_receptor_type_I_receptor_complex__plasma_membrane_	GO:0005026	transforming growth factor beta receptor activity, type II	An_anchoring_protein__SARA__recruits_R_SMAD	GO:0005515	protein binding
Signaling_by_TGF_beta	GO:0007179	transforming growth factor beta receptor signaling pathway	transforming_growth_factor_beta_receptor_binding_activity_of_Dimeric_TGF_beta_1__extracellular_region_	GO:0005160	transforming growth factor beta receptor binding	Type_II_receptor_recruits_type_I_receptor	GO:0005515	protein binding
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	Activated_Adenylate_cyclase_catalyses_cAMP_synthesis	GO:0004016	adenylate cyclase activity	cAMP_hydrolysis_by_Cam_PDE_1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	GTPase_activity_of_Dynamin_1__plasma_membrane_	GO:0003924	GTPase activity	Axonal_transport_of_NGF_Trk_complexes	GO:0003777	microtubule motor activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	GTPase_activity_of_Dynamin_1__plasma_membrane_	GO:0003924	GTPase activity	Axonal_transport_of_NGF_Trk_complexes	GO:0007018	microtubule-based movement
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	JUN_kinase_activity_of_NGF_ligand_p75NTR_NRAGE__plasma_membrane_	GO:0004705	JUN kinase activity	JNK_phosphorylates_BIM__BAD_and_other_targets	GO:0004705	JUN kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	Ral_guanyl_nucleotide_exchange_factor_activity_of_Ras_GTP_RalGDS_complex__plasma_membrane_	GO:0008321	Ral guanyl-nucleotide exchange factor activity	Activation_of_SRC_by_Ral_GTP	GO:0004713	protein tyrosine kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	_1_phosphatidylinositol_3_kinase_activity_of_Phospho_IRS1_2_PI3K_p85_p110___plasma_membrane_	GO:0016303	1-phosphatidylinositol-3-kinase activity	PTEN_dephosphorylates_PIP3	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	adenylate_cyclase_activity_of_Activated_adenylate_cyclase__plasma_membrane_	GO:0004016	adenylate cyclase activity	cAMP_hydrolysis_by_Cam_PDE_1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	calcium__and_calmodulin_responsive_adenylate_cyclase_activity_of_Adenylate_cyclase__Mg2__cofactor___plasma_membrane_	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	cAMP_hydrolysis_by_Cam_PDE_1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	guanyl_nucleotide_exchange_factor_activity_of_Active_TrkA_receptor_Phospho_Frs2_CrkL_C3G_complex__endosome_	GO:0005085	guanyl-nucleotide exchange factor activity	_Frs2_Rap1_GTP_binds_to_and_activates_B_Raf	GO:0004672	protein kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	peptidase_activity_of_gamma_secretase_complex__plasma_membrane_	GO:0008233	peptidase activity	TRAF6_polyubiquitinates_NRIF	GO:0004842	ubiquitin-protein ligase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	phosphatidylinositol_3_4_5_trisphosphate_3_phosphatase_activity_of_PTEN__Mg2__cofactor___cytosol_1	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	PI3K_produces_PIP3_and_other_phosphatidyl_inositides	GO:0016303	1-phosphatidylinositol-3-kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	phosphoinositide_phospholipase_C_activity_of_Phospho_Phospholipase_C_gamma_1__plasma_membrane_	GO:0004435	phosphoinositide phospholipase C activity	DAG_stimulates_protein_kinase_C_delta	GO:0004697	protein kinase C activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	protein_serine_threonine_kinase_activity_of_NGF_ligand_p75NTR_Phospho_IRAK1_TRAF6_p62_IKK_beta__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	IKKbeta_phosphorylates_IkB_causing_NF_kB_to_dissociate	GO:0004674	protein serine/threonine kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_BAD	GO:0004674	protein serine/threonine kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_GSK3	GO:0004674	protein serine/threonine kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_IKKalpha	GO:0004674	protein serine/threonine kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_MDM2	GO:0004674	protein serine/threonine kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_PRAS40	GO:0004674	protein serine/threonine kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates__TSC2__inhibiting_it	GO:0004674	protein serine/threonine kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_caspase_9	GO:0004674	protein serine/threonine kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_p21Cip1_and_p27Kip1	GO:0004674	protein serine/threonine kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	TORC2__mTOR__phosphorylates_AKT_at_S473	GO:0004674	protein serine/threonine kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	protein_serine_threonine_kinase_activity_of_Phospho_ERK1_2_5__nucleoplasm_	GO:0004674	protein serine/threonine kinase activity	RSK1_2_3_phosphorylates_CREB_at_Serine_133	GO:0004674	protein serine/threonine kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	protein_serine_threonine_kinase_activity_of_Phospho_ERK_dimer__nucleoplasm_	GO:0004674	protein serine/threonine kinase activity	MSK1_activates_ATF1	GO:0004674	protein serine/threonine kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	protein_serine_threonine_kinase_activity_of_Phospho_ERK_dimer__nucleoplasm_	GO:0004674	protein serine/threonine kinase activity	MSK1_activates_CREB	GO:0004674	protein serine/threonine kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	protein_serine_threonine_kinase_activity_of_Phospho_MAP_kinase_p38__nucleoplasm_	GO:0004674	protein serine/threonine kinase activity	MSK1_activates_ATF1	GO:0004674	protein serine/threonine kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	protein_serine_threonine_kinase_activity_of_Phospho_MAP_kinase_p38__nucleoplasm_	GO:0004674	protein serine/threonine kinase activity	MSK1_activates_CREB	GO:0004674	protein serine/threonine kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	protein_serine_threonine_kinase_activity_of_TORC2_complex__cytosol_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_BAD	GO:0004674	protein serine/threonine kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	protein_serine_threonine_kinase_activity_of_TORC2_complex__cytosol_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_GSK3	GO:0004674	protein serine/threonine kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	protein_serine_threonine_kinase_activity_of_TORC2_complex__cytosol_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_IKKalpha	GO:0004674	protein serine/threonine kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	protein_serine_threonine_kinase_activity_of_TORC2_complex__cytosol_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_MDM2	GO:0004674	protein serine/threonine kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	protein_serine_threonine_kinase_activity_of_TORC2_complex__cytosol_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_PRAS40	GO:0004674	protein serine/threonine kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	protein_serine_threonine_kinase_activity_of_TORC2_complex__cytosol_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates__TSC2__inhibiting_it	GO:0004674	protein serine/threonine kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	protein_serine_threonine_kinase_activity_of_TORC2_complex__cytosol_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_caspase_9	GO:0004674	protein serine/threonine kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	protein_serine_threonine_kinase_activity_of_TORC2_complex__cytosol_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_p21Cip1_and_p27Kip1	GO:0004674	protein serine/threonine kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	protein_tyrosine_kinase_activity_of_RAL_GTP__cytosol_	GO:0004713	protein tyrosine kinase activity	Binding_and_activation_of_MAP_Kinase	GO:0004713	protein tyrosine kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	protein_tyrosine_kinase_activity_of_phospho_SRC__plasma_membrane_	GO:0004713	protein tyrosine kinase activity	MAP_kinase_activates_MAPKAPK2__MAPKAPK3_and_MSK1	GO:0004674	protein serine/threonine kinase activity
Signalling_by_NGF	GO:0048011	nerve growth factor receptor signaling pathway	ubiquitin_protein_ligase_activity_of_TRAF6_homotrimer__cytosol_	GO:0004842	ubiquitin-protein ligase activity	Polyubiquitinated_NRIF_binds_to_p62__Sequestosome_	GO:0043130	ubiquitin binding
TCR_signaling	GO:0050852	T cell receptor signaling pathway	phosphatidylinositol_4_5_bisphosphate_3_kinase_activity_of_PI3K_bound_to_TRAT__plasma_membrane_	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	Hydrolysis_of_PIP3_to_PIP2	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
TCR_signaling	GO:0050852	T cell receptor signaling pathway	phosphatidylinositol_4_5_bisphosphate_3_kinase_activity_of_PI3K_bound_to_TRAT__plasma_membrane_	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	Hydrolysis_of_PIP3_to_PI_3_4_P2	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
TCR_signaling	GO:0050852	T cell receptor signaling pathway	protein_serine_threonine_kinase_activity_of_TAB2_TAK1_complex__cytosol_	GO:0004674	protein serine/threonine kinase activity	Activation_of_IKK_complex	GO:0004674	protein serine/threonine kinase activity
TCR_signaling	GO:0050852	T cell receptor signaling pathway	protein_serine_threonine_kinase_activity_of_TAK1_TAB2_complex_bound_to_TRAF6_CBM_complex__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	Ubiquitination_of_NEMO_by_TRAF6	GO:0004842	ubiquitin-protein ligase activity
TCR_signaling	GO:0050852	T cell receptor signaling pathway	protein_tyrosine_kinase_activity_of_Antigen_bearing_MHC_Class_II__TCR_complex_CD4__Lck_phosphorylated_at_Tyr394__plasma_membrane_1	GO:0004713	protein tyrosine kinase activity	Activation_of_ZAP_70	GO:0004713	protein tyrosine kinase activity
TCR_signaling	GO:0050852	T cell receptor signaling pathway	protein_tyrosine_kinase_activity_of_Antigen_bearing_MHC_Class_II__TCR_complex_CD4__Lck_phosphorylated_at_Tyr394__plasma_membrane_2	GO:0004713	protein tyrosine kinase activity	Phosphorylation_of_PKC_theta	GO:0004674	protein serine/threonine kinase activity
TCR_signaling	GO:0050852	T cell receptor signaling pathway	protein_tyrosine_kinase_activity_of_Antigen_bearing_MHC_Class_II____TCR_complex_CD4_Lck__plasma_membrane_	GO:0004713	protein tyrosine kinase activity	Phosphorylation_of_ITAM_motifs_in_CD3_complexes	GO:0004713	protein tyrosine kinase activity
TCR_signaling	GO:0050852	T cell receptor signaling pathway	protein_tyrosine_kinase_activity_of_Csk_Cbp_PAG__plasma_membrane_	GO:0004713	protein tyrosine kinase activity	Dephosphorylation_of_Lck_pY505_by_CD45	GO:0004725	protein tyrosine phosphatase activity
TCR_signaling	GO:0050852	T cell receptor signaling pathway	protein_tyrosine_kinase_activity_of_phospho_tyrosine_ZAP_70__plasma_membrane_	GO:0004713	protein tyrosine kinase activity	Phosphorylation_of_TBSMs_in_LAT	GO:0004713	protein tyrosine kinase activity
TCR_signaling	GO:0050852	T cell receptor signaling pathway	protein_tyrosine_phosphatase_activity_of_Leukocyte_common_antigen_precursor__plasma_membrane_	GO:0004725	protein tyrosine phosphatase activity	Activation_of_Lck	GO:0004713	protein tyrosine kinase activity
TCR_signaling	GO:0050852	T cell receptor signaling pathway	ubiquitin_protein_ligase_activity_of_TRAF6_trimer_bound_to_CBM_complex__plasma_membrane_	GO:0004842	ubiquitin-protein ligase activity	Activation_of_TAK1_TAB2_complex	GO:0004674	protein serine/threonine kinase activity
TCR_signaling	GO:0050852	T cell receptor signaling pathway	ubiquitin_protein_ligase_activity_of_Ub_TRAF6_trimer_bound_to_CBM_complex__plasma_membrane_	GO:0004842	ubiquitin-protein ligase activity	Activation_of_NF_kB_complex	GO:0004674	protein serine/threonine kinase activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	Activated_Adenylate_cyclase_catalyses_cAMP_synthesis	GO:0004016	adenylate cyclase activity	cAMP_hydrolysis_by_Cam_PDE_1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	Ral_guanyl_nucleotide_exchange_factor_activity_of_Ras_GTP_RalGDS_complex__plasma_membrane_	GO:0008321	Ral guanyl-nucleotide exchange factor activity	Activation_of_SRC_by_Ral_GTP	GO:0004713	protein tyrosine kinase activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	_1_phosphatidylinositol_3_kinase_activity_of_Phospho_IRS1_2_PI3K_p85_p110___plasma_membrane_	GO:0016303	1-phosphatidylinositol-3-kinase activity	PTEN_dephosphorylates_PIP3	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	adenylate_cyclase_activity_of_Activated_adenylate_cyclase__plasma_membrane_	GO:0004016	adenylate cyclase activity	cAMP_hydrolysis_by_Cam_PDE_1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	calcium__and_calmodulin_responsive_adenylate_cyclase_activity_of_Adenylate_cyclase__Mg2__cofactor___plasma_membrane_	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	cAMP_hydrolysis_by_Cam_PDE_1	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	guanyl_nucleotide_exchange_factor_activity_of_Active_TrkA_receptor_Phospho_Frs2_CrkL_C3G_complex__endosome_	GO:0005085	guanyl-nucleotide exchange factor activity	_Frs2_Rap1_GTP_binds_to_and_activates_B_Raf	GO:0004672	protein kinase activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	phosphatidylinositol_3_4_5_trisphosphate_3_phosphatase_activity_of_PTEN__Mg2__cofactor___cytosol_1	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	PI3K_produces_PIP3_and_other_phosphatidyl_inositides	GO:0016303	1-phosphatidylinositol-3-kinase activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	phosphoinositide_phospholipase_C_activity_of_Phospho_Phospholipase_C_gamma_1__plasma_membrane_	GO:0004435	phosphoinositide phospholipase C activity	DAG_stimulates_protein_kinase_C_delta	GO:0004697	protein kinase C activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_BAD	GO:0004674	protein serine/threonine kinase activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_GSK3	GO:0004674	protein serine/threonine kinase activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_IKKalpha	GO:0004674	protein serine/threonine kinase activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_MDM2	GO:0004674	protein serine/threonine kinase activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_PRAS40	GO:0004674	protein serine/threonine kinase activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates__TSC2__inhibiting_it	GO:0004674	protein serine/threonine kinase activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_caspase_9	GO:0004674	protein serine/threonine kinase activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_p21Cip1_and_p27Kip1	GO:0004674	protein serine/threonine kinase activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	protein_serine_threonine_kinase_activity_of_PIP3_PDK1_AKT__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	TORC2__mTOR__phosphorylates_AKT_at_S473	GO:0004674	protein serine/threonine kinase activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	protein_serine_threonine_kinase_activity_of_TORC2_complex__cytosol_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_BAD	GO:0004674	protein serine/threonine kinase activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	protein_serine_threonine_kinase_activity_of_TORC2_complex__cytosol_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_GSK3	GO:0004674	protein serine/threonine kinase activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	protein_serine_threonine_kinase_activity_of_TORC2_complex__cytosol_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_IKKalpha	GO:0004674	protein serine/threonine kinase activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	protein_serine_threonine_kinase_activity_of_TORC2_complex__cytosol_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_MDM2	GO:0004674	protein serine/threonine kinase activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	protein_serine_threonine_kinase_activity_of_TORC2_complex__cytosol_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_PRAS40	GO:0004674	protein serine/threonine kinase activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	protein_serine_threonine_kinase_activity_of_TORC2_complex__cytosol_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates__TSC2__inhibiting_it	GO:0004674	protein serine/threonine kinase activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	protein_serine_threonine_kinase_activity_of_TORC2_complex__cytosol_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_caspase_9	GO:0004674	protein serine/threonine kinase activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	protein_serine_threonine_kinase_activity_of_TORC2_complex__cytosol_	GO:0004674	protein serine/threonine kinase activity	AKT_phosphorylates_p21Cip1_and_p27Kip1	GO:0004674	protein serine/threonine kinase activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	protein_tyrosine_kinase_activity_of_RAL_GTP__cytosol_	GO:0004713	protein tyrosine kinase activity	Binding_and_activation_of_MAP_Kinase	GO:0004713	protein tyrosine kinase activity
TRKA_signalling_from_the_plasma_membrane	GO:0007242	intracellular signaling cascade	protein_tyrosine_kinase_activity_of_phospho_SRC__plasma_membrane_	GO:0004713	protein tyrosine kinase activity	MAP_kinase_activates_MAPKAPK2__MAPKAPK3_and_MSK1	GO:0004674	protein serine/threonine kinase activity
Toll_Like_Receptor_4__TLR4__Cascade	GO:0008063	Toll signaling pathway	kinase_activity_of_IRAK4_MyD88_Mal_activated_TLR_receptor__plasma_membrane_	GO:0016301	kinase activity	Second_phosphorylation_of_IRAK1_by_IRAK4_bound_to_activated_TLR	GO:0016301	kinase activity
Toll_Like_Receptor_4__TLR4__Cascade	GO:0008063	Toll signaling pathway	kinase_activity_of_IRAK4_MyD88_Mal_activated_TLR_receptor__plasma_membrane_1	GO:0016301	kinase activity	Multiple_IRAK1_autophosphorylation_steps	GO:0016301	kinase activity
p38MAPK_events	GO:0007242	intracellular signaling cascade	Ral_guanyl_nucleotide_exchange_factor_activity_of_Ras_GTP_RalGDS_complex__plasma_membrane_	GO:0008321	Ral guanyl-nucleotide exchange factor activity	Activation_of_SRC_by_Ral_GTP	GO:0004713	protein tyrosine kinase activity
p38MAPK_events	GO:0007242	intracellular signaling cascade	protein_tyrosine_kinase_activity_of_RAL_GTP__cytosol_	GO:0004713	protein tyrosine kinase activity	Binding_and_activation_of_MAP_Kinase	GO:0004713	protein tyrosine kinase activity
p38MAPK_events	GO:0007242	intracellular signaling cascade	protein_tyrosine_kinase_activity_of_phospho_SRC__plasma_membrane_	GO:0004713	protein tyrosine kinase activity	MAP_kinase_activates_MAPKAPK2__MAPKAPK3_and_MSK1	GO:0004674	protein serine/threonine kinase activity
p75_NTR_receptor_mediated_signalling	GO:0048011	nerve growth factor receptor signaling pathway	JUN_kinase_activity_of_NGF_ligand_p75NTR_NRAGE__plasma_membrane_	GO:0004705	JUN kinase activity	JNK_phosphorylates_BIM__BAD_and_other_targets	GO:0004705	JUN kinase activity
p75_NTR_receptor_mediated_signalling	GO:0048011	nerve growth factor receptor signaling pathway	peptidase_activity_of_gamma_secretase_complex__plasma_membrane_	GO:0008233	peptidase activity	TRAF6_polyubiquitinates_NRIF	GO:0004842	ubiquitin-protein ligase activity
p75_NTR_receptor_mediated_signalling	GO:0048011	nerve growth factor receptor signaling pathway	protein_serine_threonine_kinase_activity_of_NGF_ligand_p75NTR_Phospho_IRAK1_TRAF6_p62_IKK_beta__plasma_membrane_	GO:0004674	protein serine/threonine kinase activity	IKKbeta_phosphorylates_IkB_causing_NF_kB_to_dissociate	GO:0004674	protein serine/threonine kinase activity
p75_NTR_receptor_mediated_signalling	GO:0048011	nerve growth factor receptor signaling pathway	ubiquitin_protein_ligase_activity_of_TRAF6_homotrimer__cytosol_	GO:0004842	ubiquitin-protein ligase activity	Polyubiquitinated_NRIF_binds_to_p62__Sequestosome_	GO:0043130	ubiquitin binding