Gene Ontology OBO file definition changes

2443 / 16 direct

GO:0000988 : protein binding transcription factor activity

OLD: Interacting selectively and non-covalently with a specific protein in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well.
NEW: Interacting selectively and non-covalently with two or more protein molecules, or a protein and another macromolecule or complex, permitting those molecules to function in a coordinated way, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well.

70 / 70 direct

GO:0035058 : nonmotile primary cilium assembly

(was sensory cilium assembly)

OLD: The assembly of a sensory cilium, a primary cilium found on sensory neurons that contains an a 9+0 axonemal arrangement of microtubules.
NEW: The assembly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors. Nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules.

315 / 222 direct

GO:0042384 : cilium assembly

OLD: The assembly of a cilium, a specialized eukaryotic locomotor organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.
NEW: The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole.

65 / 65 direct

GO:0042605 : peptide antigen binding

OLD: Interacting selectively and non-covalently with an antigen peptide, a fragment of a foreign protein derived by proteolysis within the cell.
NEW: Interacting selectively and non-covalently with an antigen peptide.

4 / 4 direct

GO:0046776 : suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I

(was suppression by virus of host MHC class I cell surface presentation)

OLD: Any viral process that results in the inhibition of presentation of MHC class I antigen-presenting proteins on the host cell surface.
NEW: Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules.