Mutants with defects in RNA binding protein (RBP) are defective in cell growth and differentiation. An example RBP that regulates development is provided by the Bruno protein and its role as a translational repressor of oskar mRNA. In Drosophila, oskar is required for formation of germ cells and positioning of the posterior of the embryo.
| Text string | GO Ontology | GO Term | GO ID |
| RNA binding | function | RNA binding | GO:0003723 |
| cell growth | process | cell growth | GO:0016049 |
| differentiation | process | cell differentiation | GO:0030154 |
| translational repressor of oskar mRNA | process | negative regulation of oskar mRNA translation | GO:0007319 |
| translational repressor of oskar mRNA | function | translation repressor activity | GO:0030371 |
| formation of germ cells | process | germ-cell development | GO:0007281 |
Using microarray analysis, we identified RERG (ras-related and estrogen-regulated growth inhibitor). Like Ras, RERG protein exhibited intrinsic GDP/GTP binding and GTP hydrolysis activity. Unlike Ras proteins, RERG lacks a known recognition site for COOH-terminal prenylation and was localized primarily in the cytoplasm.
| Text string | GO Ontology | GO Term | GO ID |
| estrogen-regulated | process | response to hormone stimulus | GO:0009725 |
| growth inhibitor | process | negative regulation of cell growth | GO:0030308 |
| Ras, GDP/GTP binding | process | small GTPase mediated signal transduction | GO:0007624 |
| GDP/GTP binding | function | GDP binding | GO:0019003 |
| GDP/GTP binding | function | GTP binding | GO:0005525 |
| GTP hydrolysis | function | GTPase activity | GO:0003924 |
| cytoplasm | component | cytoplasm |