Gene Ontology OBO file definition changes
Files used:
- file 1 (old): 30:11:2010 15:48, cvs revision 1.1626
- file 2 (new): 28:01:2011 16:58, cvs revision 1.1743
- Database: seqdb, 2011-01-22
Terms with changed definitions
GO:0000059 : protein import into nucleus, docking
OLD: The aggregation, arrangement and bonding together of the nuclear localization signal of a protein with nuclear envelope proteins such as importins.
NEW: A protein complex assembly process that contributes to protein import into the nucleus, and that results in the association of a cargo protein, a carrier protein such as an importin alpha/beta heterodimer, and a nucleoporin located at the periphery of the nuclear pore complex.
GO:0000060 : protein import into nucleus, translocation
OLD: The vectorial transfer of a protein from the cytoplasm into the nucleus, through the nuclear pore and across the nuclear envelope.
NEW: A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope.
0 annotations
GO:0000061 : protein import into nucleus, substrate release
OLD: The disaggregation of a protein complex composed of the nuclear localization sequence and the importin alpha, and importin beta proteins.
NEW: A protein complex disassembly process that contributes to protein import into the nucleus, and that results in the dissociation of the cargo protein and the carrier (such as an importin alpha/beta heterodimer) from each other and from the nuclear pore complex.
GO:0000070 : mitotic sister chromatid segregation
OLD: The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
NEW: The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets.
GO:0000075 : cell cycle checkpoint
OLD: A cell cycle regulatory process that delays or stops progression through the cycle until conditions are suitable for the cell to proceed to the next stage.
NEW: A cell cycle regulatory process that controls cell cycle progression by monitoring the timing and integrity of specific cell cycle events. A cell cycle checkpoint encompasses detection of an event or biological quality, signal transduction, and effector processes that delay or stop cell cycle progression in response to a defect.
GO:0000076 : DNA replication checkpoint
OLD: A signal transduction based surveillance mechanism that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.
NEW: A cell cycle checkpoint that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome.
GO:0000077 : DNA damage checkpoint
OLD: A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds.
NEW: A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds.
GO:0000135 : septin checkpoint
OLD: A cell cycle checkpoint that detects septin defects and responds by inhibiting the mitotic CDK. In Saccharomyces cerevisiae, correct formation of a functional septin cytoskeleton permits the cell to switch to isotropic bud growth and the onset of mitotic chromosome segregation. In the presence of septin defects, the mitotic CDK is inhibited and both the switch to isotropic bud growth and the onset of mitotic chromosome segregation is delayed.
NEW: A cell cycle checkpoint that detects septin defects and responds by inhibiting the mitotic cyclin-dependent kinase (CDK). In Saccharomyces cerevisiae, correct formation of a functional septin cytoskeleton permits the cell to switch to isotropic bud growth and the onset of mitotic chromosome segregation. In the presence of septin defects, the mitotic CDK is inhibited and both the switch to isotropic bud growth and the onset of mitotic chromosome segregation is delayed.