Gene Ontology Definition Changes
Files used:
- file 1 (old): 27:01:2012 13:07, cvs revision 1.2570
- file 2 (new): 03:02:2012 17:53, cvs revision 1.2587
- Database: unknown DB type, unknown DB release name
Terms with changed definitions
GO:0000038 : very long-chain fatty acid metabolic process
(was very long chain fatty acid metabolic process)
OLD: The chemical reactions and pathways involving fatty acids with a chain length of C18 or greater.
NEW: The chemical reactions and pathways involving any long-chain fatty acid which has a chain length greater than C18.
GO:0001579 : medium-chain fatty acid transport
OLD: The directed movement of medium-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Medium-chain fatty acids are fatty acids with a chain length of between 8 and 12 carbons.
NEW: The directed movement of medium-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12.
GO:0001676 : long-chain fatty acid metabolic process
OLD: The chemical reactions and pathways involving long-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C12-18.
NEW: The chemical reactions and pathways involving long-chain fatty acids, any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
0 annotations
GO:0001792 : polymeric immunoglobulin receptor activity
OLD: Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region to initiate a change in cell activity.
NEW: Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0001847 : opsonin receptor activity
OLD: Combining with an opsonin to initiate a change in cell activity.
NEW: Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0004467 : long-chain fatty acid-CoA ligase activity
OLD: Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C12-18.
NEW: Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
GO:0004875 : complement receptor activity
OLD: Combining with any component or product of the complement cascade to initiate a change in cell activity.
NEW: Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0004896 : cytokine receptor activity
OLD: Combining with a cytokine to initiate a change in cell activity.
NEW: Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0004897 : ciliary neurotrophic factor receptor activity
OLD: Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal to initiate a change in cell activity.
NEW: Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0004900 : erythropoietin receptor activity
OLD: Combining with erythropoietin to initiate a change in cell activity.
NEW: Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
0 annotations
GO:0004902 : granulocyte colony-stimulating factor receptor activity
OLD: Combining with granulocyte colony-stimulating factor to initiate a change in cell activity.
NEW: Combining with granulocyte colony-stimulating factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0004903 : growth hormone receptor activity
OLD: Combining with growth hormone to initiate a change in cell activity.
NEW: Combining with a growth hormone and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0004904 : interferon receptor activity
OLD: Combining with an interferon to initiate a change in cell activity.
NEW: Combining with an interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0004918 : interleukin-8 receptor activity
OLD: Combining with interleukin-8 to initiate a change in cell activity.
NEW: Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0004950 : chemokine receptor activity
OLD: Combining with chemokines, small chemoattractant molecules normally used to stimulate leukocytes, to initiate a change in cell activity.
NEW: Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are small chemoattractant molecules normally used to stimulate leukocytes.
GO:0005021 : vascular endothelial growth factor-activated receptor activity
OLD: Combining with vascular endothelial growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity.
NEW: Combining with a vascular endothelial growth factor (VEGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity.
GO:0005024 : transforming growth factor beta-activated receptor activity
OLD: Combining with transforming growth factor beta to initiate a change in cell activity.
NEW: Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
0 annotations
GO:0005056 : tiggrin receptor activity
OLD: Combining with the extracellular matrix ligand tiggrin to initiate a change in cell activity.
NEW: Combining with the extracellular matrix ligand tiggrin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0005324 : long-chain fatty acid transporter activity
OLD: Enables the directed movement of long-chain fatty acids into, out of or within a cell, or between cells. Long-chain fatty acids have a chain length of greater than 12 carbons.
NEW: Enables the directed movement of long-chain fatty acids into, out of or within a cell, or between cells. A long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
GO:0008046 : axon guidance receptor activity
OLD: Combining with an extracellular messenger that results in a change in cellular activity involved in axon guidance.
NEW: Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance.
GO:0008066 : glutamate receptor activity
OLD: Combining with glutamate to initiate a change in cell activity.
NEW: Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0008281 : sulfonylurea receptor activity
OLD: Combining with sulfonylurea to initiate a change in cell activity.
NEW: Combining with sulfonylurea, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0008288 : boss receptor activity
OLD: Combining with the protein bride of sevenless (boss) to initiate a change in cell activity.
NEW: Combining with a protein bride of sevenless (boss) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.
GO:0008922 : long-chain fatty acid [acyl-carrier-protein] ligase activity
OLD: Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein].
NEW: Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
GO:0009884 : cytokinin receptor activity
OLD: Combining with a cytokinin to initiate a change in cell activity.
NEW: Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0015464 : acetylcholine receptor activity
OLD: Combining with acetylcholine to initiate a change in cell activity.
NEW: Combining with acetylcholine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
0 annotations
GO:0015483 : long-chain fatty acid transporting porin activity
OLD: Catalysis of the transfer of long-chain fatty acids from one side of the membrane to the other. Long-chain fatty acids have a chain length of greater than 12 carbons. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
NEW: Catalysis of the transfer of long-chain fatty acids from one side of the membrane to the other. Long-chain fatty acids are any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria.
0 annotations
GO:0015635 : short-chain fatty acid transporter activity
OLD: Enables the directed movement of short-chain fatty acids into, out of or within a cell, or between cells. Short-chain fatty acids have a chain length of less than 8 carbons.
NEW: Enables the directed movement of short-chain fatty acids into, out of or within a cell, or between cells. Short-chain fatty acids are fatty acids with a chain length of less than C6.
0 annotations
GO:0015636 : short-chain fatty acid uptake transporter activity
OLD: Enables the directed movement of short-chain fatty acids into a cell or organelle. Short-chain fatty acids have a chain length of less than 8 carbons.
NEW: Enables the directed movement of short-chain fatty acids into a cell or organelle. Short-chain fatty acids are fatty acids with a chain length of less than C6.
GO:0015909 : long-chain fatty acid transport
OLD: The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is an aliphatic compound with a terminal carboxyl group and with a chain length greater than C12.
NEW: The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
GO:0015910 : peroxisomal long-chain fatty acid import
OLD: The directed movement of long-chain fatty acids into a peroxisome.
NEW: The directed movement of long-chain fatty acids into a peroxisome. A long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
GO:0015911 : plasma membrane long-chain fatty acid transport
OLD: The directed movement of long-chain fatty acids across the plasma membrane.
NEW: The directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
0 annotations
GO:0015912 : short-chain fatty acid transport
OLD: The directed movement of short-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Short-chain fatty acids are fatty acids with a chain length of less than 8 carbons.
NEW: The directed movement of short-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Short-chain fatty acids are fatty acids with a chain length of less than C6.
0 annotations
GO:0015913 : short-chain fatty acid import
OLD: The directed movement of short-chain fatty acids into a cell or organelle. Short-chain fatty acids are fatty acids with a chain length of less than 8 carbons.
NEW: The directed movement of short-chain fatty acids into a cell or organelle. Short-chain fatty acids are fatty acids with a chain length of less than C6.
GO:0016167 : glial cell-derived neurotrophic factor receptor activity
OLD: Combining with glial cell line-derived neurotrophic factor to initiate a change in cell activity.
NEW: Combining with glial cell line-derived neurotrophic factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0016493 : C-C chemokine receptor activity
OLD: Combining with a C-C chemokine to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.
NEW: Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif.
GO:0016494 : C-X-C chemokine receptor activity
OLD: Combining with a C-X-C chemokine to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif.
NEW: Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif.
GO:0016495 : C-X3-C chemokine receptor activity
OLD: Combining with a C-X3-C chemokine to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif.
NEW: Combining with a C-X3-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif.
GO:0016502 : nucleotide receptor activity
OLD: Combining with a nucleotide to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule.
NEW: Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule.
GO:0016509 : long-chain-3-hydroxyacyl-CoA dehydrogenase activity
OLD: Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a long-chain fatty acid residue. Long-chain fatty acids have a chain length of between 12 and 18 carbons.
NEW: Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a long-chain fatty acid residue. A long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
GO:0016524 : latrotoxin receptor activity
OLD: Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, to initiate a change in cell activity.
NEW: Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0016917 : GABA receptor activity
OLD: Combining with gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to initiate a change in cell activity.
NEW: Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms.
GO:0017002 : activin-activated receptor activity
OLD: Combining with activin, one of two gonadal glycoproteins related to transforming growth factor beta, to initiate a change in cell activity.
NEW: Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta.
GO:0017099 : very-long-chain-acyl-CoA dehydrogenase activity
OLD: Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a very long chain fatty acid residue.
NEW: Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a very long chain fatty acid residue. A very long-chain fatty acid is a long-chain fatty acid which has a chain length greater than C18.
GO:0017154 : semaphorin receptor activity
OLD: Combining with a semaphorin to initiate a change in cell activity.
NEW: Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0019626 : short-chain fatty acid catabolic process
OLD: The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of less than 8 carbons.
NEW: The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of less than C6.
GO:0019763 : immunoglobulin receptor activity
OLD: Combining with the Fc region of an immunoglobulin protein to initiate a change in cell activity.
NEW: Combining with the Fc region of an immunoglobulin protein and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0030369 : ICAM-3 receptor activity
OLD: Combining with ICAM-3, intercellular adhesion molecule 3, to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues.
NEW: Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues.
0 annotations
GO:0031955 : short-chain fatty acid-CoA ligase activity
OLD: Catalysis of the reaction: ATP + a short-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; short-chain fatty acids have chain lengths of less than 8 carbons.
NEW: Catalysis of the reaction: ATP + a short-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; short-chain fatty acids are fatty acids with a chain length of less than C6.
GO:0031956 : medium-chain fatty acid-CoA ligase activity
OLD: Catalysis of the reaction: ATP + a medium-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; medium-chain fatty acids have chain lengths of C8-12.
NEW: Catalysis of the reaction: ATP + a medium-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a medium-chain fatty acid is any fatty acid with a chain length of between C6 and C12.
GO:0031957 : very long-chain fatty acid-CoA ligase activity
OLD: Catalysis of the reaction: ATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; very-long-chain fatty acids have chain lengths of greater than C18.
NEW: Catalysis of the reaction: ATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a very long-chain fatty acid is a long-chain fatty acid which has a chain length greater than C18.
GO:0034188 : apolipoprotein A-I receptor activity
OLD: Combining with apolipoprotein A-I and transmitting the signal to initiate a change in cell activity.
NEW: Combining with apolipoprotein A-I and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0035336 : long-chain fatty-acyl-CoA metabolic process
OLD: The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths ranging from C12-18.
NEW: The chemical reactions and pathways involving long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.
GO:0035338 : long-chain fatty-acyl-CoA biosynthetic process
OLD: The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths ranging from C12-18.
NEW: The chemical reactions and pathways resulting in the formation of a long-chain fatty-acyl-CoA any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.
0 annotations
GO:0035380 : very long-chain-3-hydroxyacyl-CoA dehydrogenase activity
OLD: Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a very long-chain fatty acid residue. Very-long-chain fatty acids have a chain length of greater than 18 carbons.
NEW: Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a very long-chain fatty acid residue. A very long-chain fatty acid is a long-chain fatty acid which has a chain length greater than C18.
GO:0035586 : purinergic receptor activity
OLD: Combining with a purine or purine derivative (purine nucleoside or purine nucleotide) to initiate a change in cell activity.
NEW: Combining with a purine or purine derivative (purine nucleoside or purine nucleotide) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule.
GO:0035790 : platelet-derived growth factor receptor-alpha signaling pathway
OLD: The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor-alpha binding to one of its physiological ligands.
NEW: A series of molecular signals initiated by the binding of a ligand to an alpha-type platelet-derived growth factor receptor (PDGFalpha) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0035791 : platelet-derived growth factor receptor-beta signaling pathway
OLD: The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor-beta binding to one of its physiological ligands.
NEW: A series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0036041 : long-chain fatty acid binding
OLD: Interacting selectively and non-covalently with a long-chain fatty acid. A long-chain fatty acid is an aliphatic compound with a terminal carboxyl group and with a chain length of C12-18.
NEW: Interacting selectively and non-covalently with a long-chain fatty acid. A long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
0 annotations
GO:0036042 : long-chain fatty acyl-CoA binding
OLD: Interacting selectively and non-covalently with a long-chain fatty acyl-CoA. A long-chain fatty acyl-CoA is any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths ranging from C12-18.
NEW: Interacting selectively and non-covalently with a long-chain fatty acyl-CoA. A long-chain fatty acyl-CoA is any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.
0 annotations
GO:0038021 : leptin receptor activity
OLD: Combining with the fat-cell specific hormone leptin to initiate a change in cell activity.
NEW: Combining with the fat-cell specific hormone leptin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
0 annotations
GO:0038033 : positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
(was vascular endothelial growth factor receptor signaling pathway involved in endothelial cell chemotaxis)
OLD: The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands, which contributes to the directed movement of an endothelial cell guided by a specific chemical concentration gradient.
NEW: A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a VEGFR on the surface of a cell, which activates or increases the frequency, rate or extent of endothelial cell chemotaxis.
GO:0042758 : long-chain fatty acid catabolic process
OLD: The chemical reactions and pathways resulting in the breakdown of long-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C12-18.
NEW: The chemical reactions and pathways resulting in the breakdown of long-chain fatty acids, any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
GO:0042759 : long-chain fatty acid biosynthetic process
OLD: The chemical reactions and pathways resulting in the formation of long-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C12-18.
NEW: The chemical reactions and pathways resulting in the formation of long-chain fatty acids, any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
GO:0042760 : very long-chain fatty acid catabolic process
OLD: The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of C18 or greater.
NEW: The chemical reactions and pathways resulting in the breakdown of a long-chain fatty acid which has a chain length greater than C18.
GO:0042761 : very long-chain fatty acid biosynthetic process
OLD: The chemical reactions and pathways resulting in the formation of fatty acids with a chain length of C18 or greater.
NEW: The chemical reactions and pathways resulting in the formation of a long-chain fatty acid which has a chain length greater than C18.
GO:0043296 : apical junction complex
OLD: A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in invertebrates is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability.
NEW: A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability.
GO:0046459 : short-chain fatty acid metabolic process
OLD: The chemical reactions and pathways involving fatty acids with a chain length of less than 8 carbons.
NEW: The chemical reactions and pathways involving fatty acids with a chain length of less than C6.
0 annotations
GO:0047474 : long-chain fatty acid luciferin component ligase activity
OLD: Catalysis of the reaction: protein + an acid + ATP = an acyl-protein thiolester + diphosphate + AMP.
NEW: Catalysis of the reaction: protein + an acid + ATP = an acyl-protein thiolester + diphosphate + AMP. A long-chain fatty acid is any fatty acid with a chain length of C13 or more. This includes very long-chain fatty acids, which have a chain length of greater than C18.
GO:0048010 : vascular endothelial growth factor receptor signaling pathway
OLD: The series of molecular signals generated as a consequence of vascular endothelial growth factor receptor binding to one of its physiological ligands.
NEW: Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor (VEGFR) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0051595 : response to methylglyoxal
OLD: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus.
NEW: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal.
GO:0051790 : short-chain fatty acid biosynthetic process
OLD: The chemical reactions and pathways resulting in the formation of fatty acids with a chain length of less than 8 carbons.
NEW: The chemical reactions and pathways resulting in the formation of fatty acids with a chain length of less than C6.
GO:0051791 : medium-chain fatty acid metabolic process
OLD: The chemical reactions and pathways involving medium-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C8-12.
NEW: The chemical reactions and pathways involving medium-chain fatty acids, any fatty acid with a chain length of between C6 and C12.
GO:0051792 : medium-chain fatty acid biosynthetic process
OLD: The chemical reactions and pathways resulting in the formation of fatty acids with a chain length of between 8 and 12 carbons.
NEW: The chemical reactions and pathways resulting in the formation of any fatty acid with a chain length of between C6 and C12.
GO:0051793 : medium-chain fatty acid catabolic process
OLD: The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of between 8 and 12 carbons.
NEW: The chemical reactions and pathways resulting in the breakdown of any fatty acid with a chain length of between C6 and C12.
0 annotations
GO:0052817 : very long chain acyl-CoA hydrolase activity
OLD: Catalysis of the reaction: H2O + a very long chain acyl-CoA = a very long chain carboxylate + CoA. A very long chain is a chain of greater than 18 carbons in length.
NEW: Catalysis of the reaction: H2O + a very long chain acyl-CoA = a very long chain carboxylate + CoA. A very long chain has chain length greater than C18.
0 annotations
GO:0052868 : protein-lysine lysyltransferase activity
OLD: Catalysis of the reaction: protein-lysine + protein-lysine = protein N6-(lysyl)-L-lysine+ protein. This reaction is the addition of lysine group from one protein to a lysine residue in a second protein, producing N6-(lysyl)-L-lysine.
NEW: Catalysis of the reaction: protein-lysine + protein-lysine = protein N6-(lysyl)-L-lysine + protein. This reaction is the addition of lysine group from one protein to a lysine residue in a second protein, producing N6-(lysyl)-L-lysine.
0 annotations
GO:0061399 : positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion
OLD: Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to an cobalt ion stimulus.
NEW: Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a cobalt ion stimulus.
GO:0070991 : medium-chain-acyl-CoA dehydrogenase activity
OLD: Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a medium-chain fatty acid residue.
NEW: Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a medium-chain fatty acid residue. A medium chain fatty acid is any fatty acid with a chain length of between C6 and C12.
GO:0097193 : intrinsic apoptotic signaling pathway
OLD: A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, growth factor withdrawal, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).
NEW: A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).
GO:1900060 : negative regulation of ceramide biosynthetic process
OLD: Any process that stops, prevents or reduces the frequency, rate or extent of ceramide biosynthetic process.
NEW: Any process that stops, prevents or reduces the frequency, rate or extent of a ceramide biosynthetic process.
GO:2000303 : regulation of ceramide biosynthetic process
OLD: Any process that modulates the frequency, rate or extent of ceramide biosynthetic process.
NEW: Any process that modulates the frequency, rate or extent of a ceramide biosynthetic process.