Gene Ontology Ontology Comparison Report ========================== Files used: - file 1 (old): go-2012-01-14.obo; date: 13:01:2012 15:54; CVS revision: 1.2512 - file 2 (new): go-2012-01-21.obo; date: 20:01:2012 15:15; CVS revision: 1.2535 NEW TERMS ========= ID name namespace GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis. biological_process GO:0002927 archaeosine-tRNA biosynthetic process biological_process GO:0036093 germ cell proliferation biological_process GO:0036094 small molecule binding molecular_function GO:0038061 NIK/NF-kappaB cascade biological_process GO:0038062 protein tyrosine kinase collagen receptor activity molecular_function GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway biological_process GO:0038064 collagen receptor activity molecular_function GO:0038065 collagen-activated signaling pathway biological_process GO:0044466 glutaryl-CoA hydrolase activity molecular_function GO:0044467 glial cell line-derived neurotrophic factor secretion biological_process GO:0044468 envenomation resulting in modulation of blood coagulation in other organism biological_process GO:0044469 envenomation resulting in positive regulation of blood coagulation in other organism biological_process GO:0044470 envenomation resulting in negative regulation of blood coagulation in other organism biological_process GO:0044471 envenomation resulting in pore formation in membrane of other organism biological_process GO:0044472 envenomation resulting in modulation of calcium channel activity in other organism biological_process GO:0044473 envenomation resulting in negative regulation of calcium channel activity in other organism biological_process GO:0044474 envenomation resulting in negative regulation of voltage-gated calcium channel activity in other organism biological_process GO:0044475 envenomation resulting in negative regulation of high voltage-gated calcium channel activity in other organism biological_process GO:0044476 envenomation resulting in negative regulation of low voltage-gated calcium channel activity in other organism biological_process GO:0044477 envenomation resulting in negative regulation of platelet aggregation in other organism biological_process GO:0044478 envenomation resulting in positive regulation of platelet aggregation in other organism biological_process GO:0044479 envenomation resulting in modulation of mast cell degranulation in other organism biological_process GO:0044480 envenomation resulting in positive regulation of mast cell degranulation in other organism biological_process GO:0044481 envenomation resulting in proteolysis in other organism biological_process GO:0044482 envenomation resulting in blood vessel extracellular matrix damage, causing hemorrhagic damage in other organism biological_process GO:0044483 envenomation resulting in impairment of hemostasis in other organism biological_process GO:0097221 MADS box-forkhead transcription factor complex cellular_component GO:1900013 cellular response to potassium ion involved in chemotaxis to cAMP biological_process GO:1900014 cellular response to calcium ion involved in chemotaxis to cAMP biological_process GO:1900031 regulation of transcription from RNA polymerase II promoter involved in calcium-mediated signaling biological_process GO:1900034 regulation of cellular response to heat biological_process GO:1900035 negative regulation of cellular response to heat biological_process GO:1900036 positive regulation of cellular response to heat biological_process GO:1900037 regulation of cellular response to hypoxia biological_process GO:1900038 negative regulation of cellular response to hypoxia biological_process GO:1900039 positive regulation of cellular response to hypoxia biological_process GO:1900040 regulation of interleukin-2 secretion biological_process GO:1900041 negative regulation of interleukin-2 secretion biological_process GO:1900042 positive regulation of interleukin-2 secretion biological_process GO:1900044 regulation of protein K63-linked ubiquitination biological_process GO:1900045 negative regulation of protein K63-linked ubiquitination biological_process GO:1900046 regulation of hemostasis biological_process GO:1900047 negative regulation of hemostasis biological_process GO:1900048 positive regulation of hemostasis biological_process GO:1900049 regulation of histone exchange biological_process GO:1900050 negative regulation of histone exchange biological_process GO:1900051 positive regulation of histone exchange biological_process GO:1900052 regulation of retinoic acid biosynthetic process biological_process GO:1900053 negative regulation of retinoic acid biosynthetic process biological_process GO:1900054 positive regulation of retinoic acid biosynthetic process biological_process OBSOLETIONS =========== None TERM MERGES =========== None TERM CHANGES ============ GO:0000124 : SAGA complex + is_a: GO:0016585 GO:0000166 : nucleotide binding - is_a: GO:0005488 + is_a: GO:0036094 GO:0000185 : activation of MAPKKK activity + relationship: positively_regulates GO:0004709 GO:0000186 : activation of MAPKK activity + relationship: positively_regulates GO:0004708 GO:0001875 : lipopolysaccharide receptor activity - def: Combining with a lipopolysaccharide to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. + def: Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. GO:0001882 : nucleoside binding - is_a: GO:0005488 + is_a: GO:0036094 GO:0002054 : nucleobase binding - is_a: GO:0005488 + is_a: GO:0036094 GO:0002176 : male germ cell proliferation - is_a: GO:0008283 - is_a: GO:0048610 + is_a: GO:0036093 - relationship: part_of GO:0007276 GO:0003130 : BMP signaling pathway involved in heart induction - def: A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to heart induction. + def: A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to heart induction. GO:0003154 : BMP signaling pathway involved in determination of left/right symmetry - def: A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the determination of left/right symmetry. + def: A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the determination of left/right symmetry. GO:0003269 : BMP signaling pathway involved in regulation of secondary heart field cardioblast proliferation - def: A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor contributing to the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. + def: A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. GO:0003302 : transforming growth factor beta receptor signaling pathway involved in heart jogging - def: The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to the process of heart jogging. + def: A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the process of heart jogging. GO:0003303 : BMP signaling pathway involved in heart jogging - def: The series of molecular signals generated as a consequence of a bone morphogenic protein receptor binding to one of its physiological ligands that contributes to the process of heart jogging. + def: A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the process of heart jogging. GO:0003434 : BMP signaling pathway involved in growth plate cartilage chondrocyte development - def: A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the progression of a growth plate cartilage chondrocyte over time. + def: A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of a growth plate cartilage chondrocyte over time. GO:0004704 : NF-kappaB-inducing kinase activity + relationship: part_of GO:0038061 GO:0004970 : ionotropic glutamate receptor activity - def: Combining with glutamate to initiate a change in cell activity through the regulation of ion channels. + def: Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts. + is_a: GO:0005230 GO:0007167 : enzyme linked receptor protein signaling pathway - def: Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase. + def: Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0007168 : receptor guanylyl cyclase signaling pathway - def: Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses guanylyl cyclase activity. + def: A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0007169 : transmembrane receptor protein tyrosine kinase signaling pathway - def: The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine kinase binding to its physiological ligand. + def: A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0007178 : transmembrane receptor protein serine/threonine kinase signaling pathway - def: The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand. + def: A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0007179 : transforming growth factor beta receptor signaling pathway - def: The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands. + def: A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0007185 : transmembrane receptor protein tyrosine phosphatase signaling pathway - def: The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine phosphatase binding to its physiological ligand. + def: A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses protein tyrosine phosphatase activity, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0007186 : G-protein coupled receptor signaling pathway - def: Any series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. + def: A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. GO:0007215 : glutamate receptor signaling pathway - name: glutamate signaling pathway + name: glutamate receptor signaling pathway - def: The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor. + def: A series of molecular signals initiated by the binding of glutamate to a glutamate receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. + synonym: "glutamate signaling pathway" EXACT [GOC:bf] GO:0007216 : G-protein coupled glutamate receptor signaling pathway - def: The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor coupled to effectors through GTP-binding proteins. + def: A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription. GO:0007219 : Notch signaling pathway - def: The series of molecular signals initiated by binding of the receptor Notch to an extracellular ligand. + def: A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0007224 : smoothened signaling pathway - def: The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened. + def: A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened. GO:0007229 : integrin-mediated signaling pathway - def: Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands. + def: A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0007249 : I-kappaB kinase/NF-kappaB cascade - def: The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of IKK and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. + def: The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. GO:0007250 : activation of NF-kappaB-inducing kinase activity + relationship: part_of GO:0038061 GO:0007254 : JNK cascade - is_a: GO:0031098 - is_a: GO:0000165 + is_a: GO:0051403 GO:0007256 : activation of JNKK activity + relationship: positively_regulates GO:0008545 GO:0008063 : Toll signaling pathway - def: The series of molecular signals initiated by binding of an extracellular ligand to the Toll receptor on the surface of the target cell. + def: A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0008101 : decapentaplegic signaling pathway - def: The series of molecular signals generated as a consequence of the signal decapentaplegic binding to one of its physiological receptors. + def: A series of molecular signals initiated by the binding of decapentaplegic (dpp) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0008293 : torso signaling pathway - def: The series of molecular signals generated as a consequence of the transmembrane receptor tyrosine kinase torso binding to its physiological ligand. + def: A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0019842 : vitamin binding - is_a: GO:0005488 + is_a: GO:0036094 GO:0021777 : BMP signaling pathway involved in spinal cord association neuron specification - def: A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to its commitment to an association neuron fate. + def: A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to its commitment to an association neuron fate. GO:0021919 : BMP signaling pathway involved in spinal cord dorsal/ventral patterning - def: A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord. + def: A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the spatial identity of regions along the dorsal-ventral axis of the spinal cord. GO:0022024 : BMP signaling pathway involved in forebrain neuron fate commitment - def: The series of molecular signals generated as a consequence of a bone morphogenic protein receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. + def: A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. GO:0022025 : leukemia inhibitory factor signaling pathway involved in forebrain neuron fate commitment - def: The series of molecular signals generated as a consequence of a leukemia inhibitory factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. + def: Any series of molecular signals initiated by the binding of leukemia inhibitory factor to a receptor on the surface of the target cell, that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain. GO:0030193 : regulation of blood coagulation + is_a: GO:1900046 GO:0030194 : positive regulation of blood coagulation + is_a: GO:1900048 GO:0030195 : negative regulation of blood coagulation + is_a: GO:1900047 GO:0030509 : BMP signaling pathway - def: A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor. + def: A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0031663 : lipopolysaccharide-mediated signaling pathway - def: The series of molecular signals generated in response to detection of lipopolysaccharide. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. + def: A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. GO:0032924 : activin receptor signaling pathway - def: A series of molecular signals generated as a consequence of any member of the activin family binding to a cell surface receptor. + def: A series of molecular signals initiated by the binding of a member of the activin family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0033209 : tumor necrosis factor-mediated signaling pathway - def: A series of molecular signals generated as a consequence of a tumor necrosis factor binding to a cell surface receptor. + def: A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0033210 : leptin-mediated signaling pathway - def: A series of molecular signals generated as a consequence of leptin binding to a cell surface receptor. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. + def: A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. GO:0033219 : urea binding + is_a: GO:0036094 GO:0035235 : ionotropic glutamate receptor signaling pathway - def: The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor, followed by the movement of ions through a channel in the receptor complex. + def: A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription. GO:0035385 : Roundabout signaling pathway - def: The series of molecular signals generated by binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of the target cell. + def: A series of molecular signals initiated by the binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0035463 : transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry - def: The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to determination of organismal asymmetry with respect to the left and right halves. + def: A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to determination of organismal asymmetry with respect to the left and right halves. GO:0035655 : interleukin-18-mediated signaling pathway - def: A series of molecular signals generated as a consequence of interleukin-18 binding to a cell surface receptor. + def: A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0035691 : macrophage migration inhibitory factor signaling pathway - def: Any series of molecular signals generated as a consequence of macrophage migration inhibitory factor binding to a cell surface receptor. + def: A series of molecular signals initiated by the binding of macrophage migration inhibitory factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0035723 : interleukin-15-mediated signaling pathway - def: A series of molecular signals generated as a consequence of interleukin-15 binding to a cell surface receptor. + def: A series of molecular signals initiated by the binding of interleukin-15 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0035738 : envenomation - def: The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the manifestation of damage to the bitten organism. + def: The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the manifestation of some change or damage to the bitten organism. GO:0035771 : interleukin-4-mediated signaling pathway - def: A series of molecular events generated as a consequence of interleukin-4 binding to a cell surface receptor. + def: A series of molecular signals initiated by the binding of interleukin-4 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0035772 : interleukin-13-mediated signaling pathway - def: A series of molecular signals generated as a consequence of interleukin-13 binding to a cell surface receptor. + def: A series of molecular signals initiated by the binding of interleukin-13 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0035806 : modulation of blood coagulation in other organism + is_a: GO:0030193 GO:0035807 : positive regulation of blood coagulation in other organism + is_a: GO:0030194 GO:0035892 : modulation of platelet aggregation in other organism + is_a: GO:0090330 GO:0035893 : negative regulation of platelet aggregation in other organism + is_a: GO:0090331 GO:0035895 : modulation of mast cell degranulation in other organism + is_a: GO:0043304 GO:0035896 : positive regulation of mast cell degranulation in other organism + is_a: GO:0043306 GO:0035897 : proteolysis in other organism + is_a: GO:0006508 GO:0035899 : negative regulation of blood coagulation in other organism + is_a: GO:0030195 GO:0035915 : pore formation in membrane of other organism - name: pore complex assembly in other organism + name: pore formation in membrane of other organism - def: The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in another organism. + def: The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of another organism. + synonym: "pore complex assembly in other organism" EXACT [] - is_a: GO:0051704 + is_a: GO:0044235 + is_a: GO:0035821 GO:0035916 : modulation of calcium channel activity in other organism + is_a: GO:0032409 GO:0035917 : negative regulation of calcium channel activity in other organism + is_a: GO:2001258 GO:0036038 : TCTN-B9D complex - name: tectonic complex + name: TCTN-B9D complex - def: A protein complex that is located at the ciliary transition zone and consists of tectonic 1 (Tctn1) in complex with other proteins. Acts to control ciliary assembly and trafficking. In mouse, other members of the complex include Mks1, Tmem216, Tmem67, Cep290, B9d1, Tctn2 and Cc2d2a. + def: A protein complex that is located at the ciliary transition zone and consists of tectonic proteins, B9 domain-containing proteins and other proteins. Acts as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. In mouse, members of the complex include TCTN1, TCTN2, B9D1, MKS1, CC2D2A and other proteins. + synonym: "B9 complex" NARROW [] + synonym: "tectonic complex" NARROW [] + synonym: "tectonic-like complex" NARROW [] GO:0038007 : netrin-activated signaling pathway - def: The series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell. The pathway begins with binding of a netrin to a cell surface receptor and ends with regulation of a downstream cellular process. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance. + def: A series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance. GO:0038025 : reelin receptor activity - def: Combining with the secreted glycoprotein reelin, and transmitting the signal to initiate a change in cell activity. + def: Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. GO:0038026 : reelin-mediated signaling pathway - def: The series of molecular signals generated as a consequence of a cell surface receptor binding to reelin, a secreted glycoprotein, to initiate a change in cell activity. + def: A series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0038042 : dimeric G-protein coupled receptor signaling pathway - def: Any series of molecular signals initiated by an extracellular signal combining with a dimeric receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Heterodimeric and homodimeric GPCRs may have different functional properties from those of the respective monomers. + def: A series of molecular signals initiated by an extracellular signal combining with a dimeric receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Heterodimeric and homodimeric GPCRs may have different functional properties from those of the respective monomers. GO:0038043 : interleukin-5-mediated signaling pathway - def: A series of molecular signals generated as a consequence of interleukin-5 binding to a cell surface receptor. + def: A series of molecular signals initiated by the binding of interleukin-5 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0038058 : TNFSF11 receptor activity - def: Combining with a tumor necrosis factor ligand superfamily member 11 (TNFSF11) and transmitting the signal within the cell to initiate a change in cell activity or function. + def: Combining with a tumor necrosis factor ligand superfamily member 11 (TNFSF11) and transmitting the signal across the cell membrane to initiate a change in cell activity or function. GO:0042655 : activation of JNKKK activity + relationship: positively_regulates GO:0004706 GO:0043177 : organic acid binding - is_a: GO:0005488 + is_a: GO:0036094 GO:0043178 : alcohol binding - is_a: GO:0005488 + is_a: GO:0036094 GO:0044281 : small molecule metabolic process - def: The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass. + def: The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. + comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. GO:0044282 : small molecule catabolic process - def: The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass. + def: The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule. + comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. GO:0044283 : small molecule biosynthetic process - def: The chemical reactions and pathways resulting in the formation of small molecules, any monomeric molecule of small relative molecular mass. + def: The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule. + comment: Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides. GO:0044359 : modulation of molecular function in other organism + is_a: GO:0065009 GO:0044362 : negative regulation of molecular function in other organism + is_a: GO:0044092 GO:0044363 : modulation of potassium channel activity in other organism + is_a: GO:0032409 GO:0044365 : envenomation resulting in modulation of platelet aggregation in other organism - def: A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with changes to the frequency, rate or extent of platelet aggregation in the bitten organism. + def: A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change to the frequency, rate or extent of platelet aggregation in the bitten organism. + synonym: "envenomation resulting in regulation of platelet aggregation in other organism" EXACT [] - is_a: GO:0035738 + is_a: GO:0044468 GO:0045500 : sevenless signaling pathway - def: The series of molecular signals generated as a consequence of the receptor sevenless binding to one of its physiological ligands. + def: A series of molecular signals initiated by the binding of an extracellular ligand to sevenless (sev; a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0046328 : regulation of JNK cascade - is_a: GO:0070302 - is_a: GO:0043408 + is_a: GO:0032872 GO:0046329 : negative regulation of JNK cascade - is_a: GO:0070303 - is_a: GO:0043409 + is_a: GO:0032873 GO:0046330 : positive regulation of JNK cascade - is_a: GO:0070304 - is_a: GO:0043410 + is_a: GO:0032874 GO:0048861 : leukemia inhibitory factor signaling pathway - def: The series of molecular signals generated as a consequence of a leukemia inhibitory factor receptor binding to one of its physiological ligands. + def: Any series of molecular signals initiated by the binding of leukemia inhibitory factor to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0051389 : inactivation of MAPKK activity + relationship: negatively_regulates GO:0004708 GO:0051390 : inactivation of MAPKKK activity + relationship: negatively_regulates GO:0004709 GO:0051927 : negative regulation of calcium ion transport via voltage-gated calcium channel activity - is_a: GO:0032413 + is_a: GO:2001258 GO:0052204 : negative regulation of molecular function in other organism involved in symbiotic interaction - is_a: GO:0044092 GO:0052205 : modulation of molecular function in other organism involved in symbiotic interaction - is_a: GO:0065009 GO:0060337 : type I interferon-mediated signaling pathway - def: A series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. + def: A series of molecular signals initiated by the binding of a type I interferon binding to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. GO:0060490 : lateral sprouting involved in lung morphogenesis + intersection_of: GO:0060601 + intersection_of: part_of GO:0060441 GO:0060599 : lateral sprouting involved in mammary gland duct morphogenesis + intersection_of: GO:0060601 + intersection_of: part_of GO:0060444 GO:0060660 : epidermis morphogenesis involved in nipple formation + intersection_of: GO:0048730 + intersection_of: part_of GO:0060658 GO:0060680 : lateral sprouting involved in ureteric bud morphogenesis + intersection_of: GO:0060601 + intersection_of: part_of GO:0001658 GO:0060797 : transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment - def: The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the commitment of an unspecified fate to adopt a mesoderm fate. + def: A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to an unspecified cell adopting a mesoderm fate. GO:0060803 : BMP signaling pathway involved in mesodermal cell fate specification - def: A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor and ultimately resulting in an cell becoming specified to adopt a mesodermal fate. + def: A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to a cell becoming specified to adopt a mesodermal fate. GO:0060826 : transforming growth factor beta receptor signaling pathway involved in neural plate anterior/posterior pattern formation - def: The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands, contributing to the formation of the neural plate anterior/posterior pattern. + def: A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the formation of the neural plate anterior/posterior pattern. GO:0060835 : transforming growth factor receptor beta signaling pathway involved in oral/aboral axis specification - def: The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to the specification of the oral/aboral axis. + def: A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the specification of the oral/aboral axis. GO:0060869 : transmembrane receptor protein serine/threonine kinase signaling pathway involved in floral organ abscission - def: The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand that contributes to the process of floral organ abscission. + def: A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, which contributes to the process of floral organ abscission. GO:0061057 : peptidoglycan recognition protein signaling pathway - def: The series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and mediated by Imd. The main outcome of the Imd signaling is the production of antimicrobial peptides. + def: A series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides. GO:0061149 : BMP signaling pathway involved in ureter morphogenesis - def: A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the shaping of the ureter. The ureter is a tube that extends from the kidney to the bladder. + def: A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the shaping of the ureter. The ureter is a tube that extends from the kidney to the bladder. GO:0061151 : BMP signaling pathway involved in renal system segmentation - def: A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor and contributing to the segmentation of the renal system. + def: A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the segmentation of the renal system. GO:0061312 : BMP signaling pathway involved in heart development - def: A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor and contributing to the progression of the heart over time. + def: A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of the heart over time. GO:0061353 : BMP signaling pathway involved in Malpighian tubule cell chemotaxis - def: The series of molecular signals generated as a consequence of a BMP receptor binding to one of its physiological ligands leading to the directed movement of a Malpighian tubule cells toward a stimulus and contributing to the shaping of the tubule. + def: A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the directed movement of a Malpighian tubule cell toward a stimulus, thereby contributing to the shaping of the tubule. GO:0061372 : activin receptor signaling pathway involved in heart jogging - def: A series of molecular signals generated as a consequence of any member of the activin family binding to a cell surface receptor and contributing to the process of heart jogging. + def: A series of molecular signals initiated by the binding of a member of the activin family to a receptor on the surface of a target cell, and contributing to the process of heart jogging. GO:0070102 : interleukin-6-mediated signaling pathway - def: A series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor. + def: A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0070106 : interleukin-27-mediated signaling pathway - def: A series of molecular events generated as a consequence of interleukin-27 binding to a cell surface receptor. + def: A series of molecular signals initiated by the binding of interleukin-27 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0070757 : interleukin-35-mediated signaling pathway - def: A series of molecular events generated as a consequence of interleukin-35 binding to a cell surface receptor. + def: A series of molecular signals initiated by the binding of interleukin-35 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0071847 : TNFSF11-mediated signaling pathway - def: A series of molecular signals generated as a consequence of tumor necrosis factor ligand superfamily member 11 (TNFSF11) binding to a cell surface receptor. + def: A series of molecular signals initiated by the binding of tumor necrosis factor ligand superfamily member 11 (TNFSF11) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0071893 : BMP signaling pathway involved in nephric duct formation - def: A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to nephric duct formation. + def: A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to nephric duct formation. GO:0090010 : transforming growth factor beta receptor signaling pathway involved in primitive streak formation - def: The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands contributing to the formation of the primitive streak. + def: A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the formation of the primitive streak. GO:0090247 : cell motility involved in somitogenic axis elongation + intersection_of: GO:0048870 + intersection_of: part_of GO:0090245 GO:2000728 : regulation of mRNA export from nucleus in response to heat stress - is_a: GO:0080135 + is_a: GO:1900034 FILE STATS ========== Term counts for the old and new files Ontology Old file New file Change molecular function 9208 9212 +4 (9208 defined) (9212 defined) cellular component 2949 2950 +1 (2949 defined) (2950 defined) biological process 21823 21867 +44 (21823 defined) (21867 defined) Obsolete 1609 1611 +2 (4.5% of total) (4.5% of total) (+0.1%) Totals 33980 34029 +51 (+0.1%) 33980 (100.0%) defined 34029 (100.0%) defined 35589 inc. obs 35640 inc. obs