Gene Ontology: Ontology Comparison Report

Files used:

  • file 1 (old): go-2012-01-14.obo; date: 13:01:2012 15:54; CVS revision: 1.2512
  • file 2 (new): go-2012-01-21.obo; date: 20:01:2012 15:15; CVS revision: 1.2535

New terms

ID name namespace
GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis. biological_process
GO:0002927 archaeosine-tRNA biosynthetic process biological_process
GO:0036093 germ cell proliferation biological_process
GO:0036094 small molecule binding molecular_function
GO:0038061 NIK/NF-kappaB cascade biological_process
GO:0038062 protein tyrosine kinase collagen receptor activity molecular_function
GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway biological_process
GO:0038064 collagen receptor activity molecular_function
GO:0038065 collagen-activated signaling pathway biological_process
GO:0044466 glutaryl-CoA hydrolase activity molecular_function
GO:0044467 glial cell line-derived neurotrophic factor secretion biological_process
GO:0044468 envenomation resulting in modulation of blood coagulation in other organism biological_process
GO:0044469 envenomation resulting in positive regulation of blood coagulation in other organism biological_process
GO:0044470 envenomation resulting in negative regulation of blood coagulation in other organism biological_process
GO:0044471 envenomation resulting in pore formation in membrane of other organism biological_process
GO:0044472 envenomation resulting in modulation of calcium channel activity in other organism biological_process
GO:0044473 envenomation resulting in negative regulation of calcium channel activity in other organism biological_process
GO:0044474 envenomation resulting in negative regulation of voltage-gated calcium channel activity in other organism biological_process
GO:0044475 envenomation resulting in negative regulation of high voltage-gated calcium channel activity in other organism biological_process
GO:0044476 envenomation resulting in negative regulation of low voltage-gated calcium channel activity in other organism biological_process
GO:0044477 envenomation resulting in negative regulation of platelet aggregation in other organism biological_process
GO:0044478 envenomation resulting in positive regulation of platelet aggregation in other organism biological_process
GO:0044479 envenomation resulting in modulation of mast cell degranulation in other organism biological_process
GO:0044480 envenomation resulting in positive regulation of mast cell degranulation in other organism biological_process
GO:0044481 envenomation resulting in proteolysis in other organism biological_process
GO:0044482 envenomation resulting in blood vessel extracellular matrix damage, causing hemorrhagic damage in other organism biological_process
GO:0044483 envenomation resulting in impairment of hemostasis in other organism biological_process
GO:0097221 MADS box-forkhead transcription factor complex cellular_component
GO:1900013 cellular response to potassium ion involved in chemotaxis to cAMP biological_process
GO:1900014 cellular response to calcium ion involved in chemotaxis to cAMP biological_process
GO:1900031 regulation of transcription from RNA polymerase II promoter involved in calcium-mediated signaling biological_process
GO:1900034 regulation of cellular response to heat biological_process
GO:1900035 negative regulation of cellular response to heat biological_process
GO:1900036 positive regulation of cellular response to heat biological_process
GO:1900037 regulation of cellular response to hypoxia biological_process
GO:1900038 negative regulation of cellular response to hypoxia biological_process
GO:1900039 positive regulation of cellular response to hypoxia biological_process
GO:1900040 regulation of interleukin-2 secretion biological_process
GO:1900041 negative regulation of interleukin-2 secretion biological_process
GO:1900042 positive regulation of interleukin-2 secretion biological_process
GO:1900044 regulation of protein K63-linked ubiquitination biological_process
GO:1900045 negative regulation of protein K63-linked ubiquitination biological_process
GO:1900046 regulation of hemostasis biological_process
GO:1900047 negative regulation of hemostasis biological_process
GO:1900048 positive regulation of hemostasis biological_process
GO:1900049 regulation of histone exchange biological_process
GO:1900050 negative regulation of histone exchange biological_process
GO:1900051 positive regulation of histone exchange biological_process
GO:1900052 regulation of retinoic acid biosynthetic process biological_process
GO:1900053 negative regulation of retinoic acid biosynthetic process biological_process
GO:1900054 positive regulation of retinoic acid biosynthetic process biological_process

Obsoletions

None

Term merges

None

Term changes

Changes in term-related data
File 1 (13:01:2012 15:54, 1.2512) File 2 (20:01:2012 15:15, 1.2535)
GO:0000124 : SAGA complex
is_a
GO:0016585
GO:0000166 : nucleotide binding
is_a
GO:0005488
 is_a
GO:0036094
GO:0000185 : activation of MAPKKK activity
relationship
positively_regulates GO:0004709
GO:0000186 : activation of MAPKK activity
relationship
positively_regulates GO:0004708
GO:0001875 : lipopolysaccharide receptor activity
def
Combining with a lipopolysaccharide to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
 def
Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
GO:0001882 : nucleoside binding
is_a
GO:0005488
 is_a
GO:0036094
GO:0002054 : nucleobase binding
is_a
GO:0005488
 is_a
GO:0036094
GO:0002176 : male germ cell proliferation
is_a
GO:0008283
GO:0048610
relationship
part_of GO:0007276
 is_a
GO:0036093
GO:0003130 : BMP signaling pathway involved in heart induction
def
A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to heart induction.
 def
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to heart induction.
GO:0003154 : BMP signaling pathway involved in determination of left/right symmetry
def
A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the determination of left/right symmetry.
 def
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the determination of left/right symmetry.
GO:0003269 : BMP signaling pathway involved in regulation of secondary heart field cardioblast proliferation
def
A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor contributing to the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
 def
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.
GO:0003302 : transforming growth factor beta receptor signaling pathway involved in heart jogging
def
The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to the process of heart jogging.
 def
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the process of heart jogging.
GO:0003303 : BMP signaling pathway involved in heart jogging
def
The series of molecular signals generated as a consequence of a bone morphogenic protein receptor binding to one of its physiological ligands that contributes to the process of heart jogging.
 def
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the process of heart jogging.
GO:0003434 : BMP signaling pathway involved in growth plate cartilage chondrocyte development
def
A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the progression of a growth plate cartilage chondrocyte over time.
 def
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of a growth plate cartilage chondrocyte over time.
GO:0004704 : NF-kappaB-inducing kinase activity
relationship
part_of GO:0038061
GO:0004970 : ionotropic glutamate receptor activity
def
Combining with glutamate to initiate a change in cell activity through the regulation of ion channels.
 def
Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts.
is_a
GO:0005230
GO:0007167 : enzyme linked receptor protein signaling pathway
def
Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase.
 def
Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0007168 : receptor guanylyl cyclase signaling pathway
def
Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses guanylyl cyclase activity.
 def
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0007169 : transmembrane receptor protein tyrosine kinase signaling pathway
def
The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine kinase binding to its physiological ligand.
 def
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0007178 : transmembrane receptor protein serine/threonine kinase signaling pathway
def
The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand.
 def
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0007179 : transforming growth factor beta receptor signaling pathway
def
The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands.
 def
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0007185 : transmembrane receptor protein tyrosine phosphatase signaling pathway
def
The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine phosphatase binding to its physiological ligand.
 def
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses protein tyrosine phosphatase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0007186 : G-protein coupled receptor signaling pathway
def
Any series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.
 def
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.
GO:0007215 : glutamate receptor signaling pathway
name
glutamate signaling pathway
def
The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor.
 name
glutamate receptor signaling pathway
def
A series of molecular signals initiated by the binding of glutamate to a glutamate receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
synonym
"glutamate signaling pathway" EXACT [GOC:bf]
GO:0007216 : G-protein coupled glutamate receptor signaling pathway
def
The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor coupled to effectors through GTP-binding proteins.
 def
A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription.
GO:0007219 : Notch signaling pathway
def
The series of molecular signals initiated by binding of the receptor Notch to an extracellular ligand.
 def
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0007224 : smoothened signaling pathway
def
The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
 def
A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
GO:0007229 : integrin-mediated signaling pathway
def
Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands.
 def
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0007249 : I-kappaB kinase/NF-kappaB cascade
def
The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of IKK and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
 def
The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
GO:0007250 : activation of NF-kappaB-inducing kinase activity
relationship
part_of GO:0038061
GO:0007254 : JNK cascade
is_a
GO:0000165
GO:0031098
 is_a
GO:0051403
GO:0007256 : activation of JNKK activity
relationship
positively_regulates GO:0008545
GO:0008063 : Toll signaling pathway
def
The series of molecular signals initiated by binding of an extracellular ligand to the Toll receptor on the surface of the target cell.
 def
A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0008101 : decapentaplegic signaling pathway
def
The series of molecular signals generated as a consequence of the signal decapentaplegic binding to one of its physiological receptors.
 def
A series of molecular signals initiated by the binding of decapentaplegic (dpp) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0008293 : torso signaling pathway
def
The series of molecular signals generated as a consequence of the transmembrane receptor tyrosine kinase torso binding to its physiological ligand.
 def
A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0019842 : vitamin binding
is_a
GO:0005488
 is_a
GO:0036094
GO:0021777 : BMP signaling pathway involved in spinal cord association neuron specification
def
A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to its commitment to an association neuron fate.
 def
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to its commitment to an association neuron fate.
GO:0021919 : BMP signaling pathway involved in spinal cord dorsal/ventral patterning
def
A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord.
 def
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the spatial identity of regions along the dorsal-ventral axis of the spinal cord.
GO:0022024 : BMP signaling pathway involved in forebrain neuron fate commitment
def
The series of molecular signals generated as a consequence of a bone morphogenic protein receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.
 def
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.
GO:0022025 : leukemia inhibitory factor signaling pathway involved in forebrain neuron fate commitment
def
The series of molecular signals generated as a consequence of a leukemia inhibitory factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.
 def
Any series of molecular signals initiated by the binding of leukemia inhibitory factor to a receptor on the surface of the target cell, that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain.
GO:0030193 : regulation of blood coagulation
is_a
GO:1900046
GO:0030194 : positive regulation of blood coagulation
is_a
GO:1900048
GO:0030195 : negative regulation of blood coagulation
is_a
GO:1900047
GO:0030509 : BMP signaling pathway
def
A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor.
 def
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0031663 : lipopolysaccharide-mediated signaling pathway
def
The series of molecular signals generated in response to detection of lipopolysaccharide. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
 def
A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
GO:0032924 : activin receptor signaling pathway
def
A series of molecular signals generated as a consequence of any member of the activin family binding to a cell surface receptor.
 def
A series of molecular signals initiated by the binding of a member of the activin family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0033209 : tumor necrosis factor-mediated signaling pathway
def
A series of molecular signals generated as a consequence of a tumor necrosis factor binding to a cell surface receptor.
 def
A series of molecular signals initiated by the binding of a tumor necrosis factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0033210 : leptin-mediated signaling pathway
def
A series of molecular signals generated as a consequence of leptin binding to a cell surface receptor. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.
 def
A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.
GO:0033219 : urea binding
is_a
GO:0036094
GO:0035235 : ionotropic glutamate receptor signaling pathway
def
The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor, followed by the movement of ions through a channel in the receptor complex.
 def
A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex. Ends with regulation of a downstream cellular process, e.g. transcription.
GO:0035385 : Roundabout signaling pathway
def
The series of molecular signals generated by binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of the target cell.
 def
A series of molecular signals initiated by the binding of a SLIT protein to a Roundabout (ROBO) family receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0035463 : transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry
def
The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to determination of organismal asymmetry with respect to the left and right halves.
 def
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to determination of organismal asymmetry with respect to the left and right halves.
GO:0035655 : interleukin-18-mediated signaling pathway
def
A series of molecular signals generated as a consequence of interleukin-18 binding to a cell surface receptor.
 def
A series of molecular signals initiated by the binding of interleukin-18 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0035691 : macrophage migration inhibitory factor signaling pathway
def
Any series of molecular signals generated as a consequence of macrophage migration inhibitory factor binding to a cell surface receptor.
 def
A series of molecular signals initiated by the binding of macrophage migration inhibitory factor to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0035723 : interleukin-15-mediated signaling pathway
def
A series of molecular signals generated as a consequence of interleukin-15 binding to a cell surface receptor.
 def
A series of molecular signals initiated by the binding of interleukin-15 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0035738 : envenomation
def
The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the manifestation of damage to the bitten organism.
 def
The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the manifestation of some change or damage to the bitten organism.
GO:0035771 : interleukin-4-mediated signaling pathway
def
A series of molecular events generated as a consequence of interleukin-4 binding to a cell surface receptor.
 def
A series of molecular signals initiated by the binding of interleukin-4 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0035772 : interleukin-13-mediated signaling pathway
def
A series of molecular signals generated as a consequence of interleukin-13 binding to a cell surface receptor.
 def
A series of molecular signals initiated by the binding of interleukin-13 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0035806 : modulation of blood coagulation in other organism
is_a
GO:0030193
GO:0035807 : positive regulation of blood coagulation in other organism
is_a
GO:0030194
GO:0035892 : modulation of platelet aggregation in other organism
is_a
GO:0090330
GO:0035893 : negative regulation of platelet aggregation in other organism
is_a
GO:0090331
GO:0035895 : modulation of mast cell degranulation in other organism
is_a
GO:0043304
GO:0035896 : positive regulation of mast cell degranulation in other organism
is_a
GO:0043306
GO:0035897 : proteolysis in other organism
is_a
GO:0006508
GO:0035899 : negative regulation of blood coagulation in other organism
is_a
GO:0030195
GO:0035915 : pore formation in membrane of other organism
name
pore complex assembly in other organism
def
The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in another organism.
is_a
GO:0051704
 name
pore formation in membrane of other organism
def
The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of another organism.
synonym
"pore complex assembly in other organism" EXACT []
is_a
GO:0035821
GO:0044235
GO:0035916 : modulation of calcium channel activity in other organism
is_a
GO:0032409
GO:0035917 : negative regulation of calcium channel activity in other organism
is_a
GO:2001258
GO:0036038 : TCTN-B9D complex
name
tectonic complex
def
A protein complex that is located at the ciliary transition zone and consists of tectonic 1 (Tctn1) in complex with other proteins. Acts to control ciliary assembly and trafficking. In mouse, other members of the complex include Mks1, Tmem216, Tmem67, Cep290, B9d1, Tctn2 and Cc2d2a.
 name
TCTN-B9D complex
def
A protein complex that is located at the ciliary transition zone and consists of tectonic proteins, B9 domain-containing proteins and other proteins. Acts as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. In mouse, members of the complex include TCTN1, TCTN2, B9D1, MKS1, CC2D2A and other proteins.
synonym
"B9 complex" NARROW []
"tectonic complex" NARROW []
"tectonic-like complex" NARROW []
GO:0038007 : netrin-activated signaling pathway
def
The series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell. The pathway begins with binding of a netrin to a cell surface receptor and ends with regulation of a downstream cellular process. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance.
 def
A series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance.
GO:0038025 : reelin receptor activity
def
Combining with the secreted glycoprotein reelin, and transmitting the signal to initiate a change in cell activity.
 def
Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
GO:0038026 : reelin-mediated signaling pathway
def
The series of molecular signals generated as a consequence of a cell surface receptor binding to reelin, a secreted glycoprotein, to initiate a change in cell activity.
 def
A series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0038042 : dimeric G-protein coupled receptor signaling pathway
def
Any series of molecular signals initiated by an extracellular signal combining with a dimeric receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Heterodimeric and homodimeric GPCRs may have different functional properties from those of the respective monomers.
 def
A series of molecular signals initiated by an extracellular signal combining with a dimeric receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Heterodimeric and homodimeric GPCRs may have different functional properties from those of the respective monomers.
GO:0038043 : interleukin-5-mediated signaling pathway
def
A series of molecular signals generated as a consequence of interleukin-5 binding to a cell surface receptor.
 def
A series of molecular signals initiated by the binding of interleukin-5 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0038058 : TNFSF11 receptor activity
def
Combining with a tumor necrosis factor ligand superfamily member 11 (TNFSF11) and transmitting the signal within the cell to initiate a change in cell activity or function.
 def
Combining with a tumor necrosis factor ligand superfamily member 11 (TNFSF11) and transmitting the signal across the cell membrane to initiate a change in cell activity or function.
GO:0042655 : activation of JNKKK activity
relationship
positively_regulates GO:0004706
GO:0043177 : organic acid binding
is_a
GO:0005488
 is_a
GO:0036094
GO:0043178 : alcohol binding
is_a
GO:0005488
 is_a
GO:0036094
GO:0044281 : small molecule metabolic process
def
The chemical reactions and pathways involving small molecules, any monomeric molecule of small relative molecular mass.
 def
The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.
comment
Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.
GO:0044282 : small molecule catabolic process
def
The chemical reactions and pathways resulting in the breakdown of small molecules, any monomeric molecule of small relative molecular mass.
 def
The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule.
comment
Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.
GO:0044283 : small molecule biosynthetic process
def
The chemical reactions and pathways resulting in the formation of small molecules, any monomeric molecule of small relative molecular mass.
 def
The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule.
comment
Small molecules in GO include monosaccharides but exclude disaccharides and polysaccharides.
GO:0044359 : modulation of molecular function in other organism
is_a
GO:0065009
GO:0044362 : negative regulation of molecular function in other organism
is_a
GO:0044092
GO:0044363 : modulation of potassium channel activity in other organism
is_a
GO:0032409
GO:0044365 : envenomation resulting in modulation of platelet aggregation in other organism
def
A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with changes to the frequency, rate or extent of platelet aggregation in the bitten organism.
is_a
GO:0035738
 def
A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change to the frequency, rate or extent of platelet aggregation in the bitten organism.
synonym
"envenomation resulting in regulation of platelet aggregation in other organism" EXACT []
is_a
GO:0044468
GO:0045500 : sevenless signaling pathway
def
The series of molecular signals generated as a consequence of the receptor sevenless binding to one of its physiological ligands.
 def
A series of molecular signals initiated by the binding of an extracellular ligand to sevenless (sev; a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0046328 : regulation of JNK cascade
is_a
GO:0043408
GO:0070302
 is_a
GO:0032872
GO:0046329 : negative regulation of JNK cascade
is_a
GO:0043409
GO:0070303
 is_a
GO:0032873
GO:0046330 : positive regulation of JNK cascade
is_a
GO:0043410
GO:0070304
 is_a
GO:0032874
GO:0048861 : leukemia inhibitory factor signaling pathway
def
The series of molecular signals generated as a consequence of a leukemia inhibitory factor receptor binding to one of its physiological ligands.
 def
Any series of molecular signals initiated by the binding of leukemia inhibitory factor to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0051389 : inactivation of MAPKK activity
relationship
negatively_regulates GO:0004708
GO:0051390 : inactivation of MAPKKK activity
relationship
negatively_regulates GO:0004709
GO:0051927 : negative regulation of calcium ion transport via voltage-gated calcium channel activity
is_a
GO:0032413
 is_a
GO:2001258
GO:0052204 : negative regulation of molecular function in other organism involved in symbiotic interaction
is_a
GO:0044092
GO:0052205 : modulation of molecular function in other organism involved in symbiotic interaction
is_a
GO:0065009
GO:0060337 : type I interferon-mediated signaling pathway
def
A series of molecular events generated as a consequence of a type I interferon binding to a cell surface receptor. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
 def
A series of molecular signals initiated by the binding of a type I interferon binding to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
GO:0060490 : lateral sprouting involved in lung morphogenesis
intersection_of
GO:0060601
part_of GO:0060441
GO:0060599 : lateral sprouting involved in mammary gland duct morphogenesis
intersection_of
GO:0060601
part_of GO:0060444
GO:0060660 : epidermis morphogenesis involved in nipple formation
intersection_of
GO:0048730
part_of GO:0060658
GO:0060680 : lateral sprouting involved in ureteric bud morphogenesis
intersection_of
GO:0060601
part_of GO:0001658
GO:0060797 : transforming growth factor beta receptor signaling pathway involved in primary germ layer cell fate commitment
def
The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands and ultimately resulting in the commitment of an unspecified fate to adopt a mesoderm fate.
 def
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to an unspecified cell adopting a mesoderm fate.
GO:0060803 : BMP signaling pathway involved in mesodermal cell fate specification
def
A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor and ultimately resulting in an cell becoming specified to adopt a mesodermal fate.
 def
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to a cell becoming specified to adopt a mesodermal fate.
GO:0060826 : transforming growth factor beta receptor signaling pathway involved in neural plate anterior/posterior pattern formation
def
The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands, contributing to the formation of the neural plate anterior/posterior pattern.
 def
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the formation of the neural plate anterior/posterior pattern.
GO:0060835 : transforming growth factor receptor beta signaling pathway involved in oral/aboral axis specification
def
The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to the specification of the oral/aboral axis.
 def
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the specification of the oral/aboral axis.
GO:0060869 : transmembrane receptor protein serine/threonine kinase signaling pathway involved in floral organ abscission
def
The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand that contributes to the process of floral organ abscission.
 def
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, which contributes to the process of floral organ abscission.
GO:0061057 : peptidoglycan recognition protein signaling pathway
def
The series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and mediated by Imd. The main outcome of the Imd signaling is the production of antimicrobial peptides.
 def
A series of molecular signals initiated by binding of peptidoglycan to a receptor on the surface of the target cell and ending with regulation of a downstream cellular process. The main outcome of the Imd signaling is the production of antimicrobial peptides.
GO:0061149 : BMP signaling pathway involved in ureter morphogenesis
def
A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the shaping of the ureter. The ureter is a tube that extends from the kidney to the bladder.
 def
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the shaping of the ureter. The ureter is a tube that extends from the kidney to the bladder.
GO:0061151 : BMP signaling pathway involved in renal system segmentation
def
A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor and contributing to the segmentation of the renal system.
 def
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the segmentation of the renal system.
GO:0061312 : BMP signaling pathway involved in heart development
def
A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor and contributing to the progression of the heart over time.
 def
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of the heart over time.
GO:0061353 : BMP signaling pathway involved in Malpighian tubule cell chemotaxis
def
The series of molecular signals generated as a consequence of a BMP receptor binding to one of its physiological ligands leading to the directed movement of a Malpighian tubule cells toward a stimulus and contributing to the shaping of the tubule.
 def
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the directed movement of a Malpighian tubule cell toward a stimulus, thereby contributing to the shaping of the tubule.
GO:0061372 : activin receptor signaling pathway involved in heart jogging
def
A series of molecular signals generated as a consequence of any member of the activin family binding to a cell surface receptor and contributing to the process of heart jogging.
 def
A series of molecular signals initiated by the binding of a member of the activin family to a receptor on the surface of a target cell, and contributing to the process of heart jogging.
GO:0070102 : interleukin-6-mediated signaling pathway
def
A series of molecular events generated as a consequence of interleukin-6 binding to a cell surface receptor.
 def
A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0070106 : interleukin-27-mediated signaling pathway
def
A series of molecular events generated as a consequence of interleukin-27 binding to a cell surface receptor.
 def
A series of molecular signals initiated by the binding of interleukin-27 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0070757 : interleukin-35-mediated signaling pathway
def
A series of molecular events generated as a consequence of interleukin-35 binding to a cell surface receptor.
 def
A series of molecular signals initiated by the binding of interleukin-35 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0071847 : TNFSF11-mediated signaling pathway
def
A series of molecular signals generated as a consequence of tumor necrosis factor ligand superfamily member 11 (TNFSF11) binding to a cell surface receptor.
 def
A series of molecular signals initiated by the binding of tumor necrosis factor ligand superfamily member 11 (TNFSF11) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
GO:0071893 : BMP signaling pathway involved in nephric duct formation
def
A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to nephric duct formation.
 def
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to nephric duct formation.
GO:0090010 : transforming growth factor beta receptor signaling pathway involved in primitive streak formation
def
The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands contributing to the formation of the primitive streak.
 def
A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the formation of the primitive streak.
GO:0090247 : cell motility involved in somitogenic axis elongation
intersection_of
GO:0048870
part_of GO:0090245
GO:2000728 : regulation of mRNA export from nucleus in response to heat stress
is_a
GO:0080135
 is_a
GO:1900034

File Stats

Term counts for the old and new files
Ontology Old file New file Change
molecular function 9208
9208 (100.0%) defined 		9212
9212 (100.0%) defined 		+4
cellular component 2949
2949 (100.0%) defined 		2950
2950 (100.0%) defined 		+1
biological process 21823
21823 (100.0%) defined 		21867
21867 (100.0%) defined 		+44
Obsolete 1609
(4.5% of total)		 1611
(4.5% of total)		 +2 (+0.1%)
Totals 33980
33980 (100.0%) defined
35589 inc. obsoletes 		34029
34029 (100.0%) defined
35640 inc. obsoletes 		+51 (+0.1%)

Ontology report info