Gene Ontology Ontology Comparison Report ========================== Files used: - file 1 (old): go-2012-01-07.obo; date: 06:01:2012 16:33; CVS revision: 1.2481 - file 2 (new): go-2012-01-14.obo; date: 13:01:2012 15:54; CVS revision: 1.2512 NEW TERMS ========= ID name namespace GO:0036089 cleavage furrow formation biological_process GO:0036090 cleavage furrow ingression biological_process GO:0036091 positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress biological_process GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process biological_process GO:0038059 IKKalpha-IKKalpha complex cellular_component GO:0038060 nitric oxide-cGMP-mediated signaling pathway biological_process GO:0044458 motile cilium assembly biological_process GO:0044465 regulation of sensory perception of pain in another organism biological_process GO:0052867 phosphatidylinositol-1,4,5-trisphosphate 5-phosphatase activity molecular_function GO:0052868 protein-lysine lysyltransferase activity molecular_function GO:0061396 regulation of transcription from RNA polymerase II promoter in response to copper ion biological_process GO:0061397 positive regulation of transcription from RNA polymerase II promoter in response to copper ion biological_process GO:0061398 negative regulation of transcription from RNA polymerase II promoter in response to copper ion biological_process GO:0061399 positive regulation of transcription from RNA polymerase II promoter in response to cobalt ion biological_process GO:0061400 positive regulation of transcription from RNA polymerase II promoter in response to calcium ion biological_process GO:0061401 positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment biological_process GO:0061402 positive regulation of transcription from RNA polymerase II promoter in response to acidity biological_process GO:0061403 positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress biological_process GO:0061404 positive regulation of transcription from RNA polymerase II promoter in response to increased salt biological_process GO:0061405 positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure biological_process GO:0061406 positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation biological_process GO:0061407 positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide biological_process GO:0061408 positive regulation of transcription from RNA polymerase II promoter in response to heat stress biological_process GO:0061409 positive regulation of transcription from RNA polymerase II promoter in response to freezing biological_process GO:0061410 positive regulation of transcription from RNA polymerase II promoter in response to ethanol biological_process GO:0061411 positive regulation of transcription from RNA polymerase II promoter in response to cold biological_process GO:0061412 positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation biological_process GO:0097210 response to gonadotropin-releasing hormone biological_process GO:0097211 cellular response to gonadotropin-releasing hormone biological_process GO:0097212 lysosomal membrane organization biological_process GO:0097213 regulation of lysosomal membrane permeability biological_process GO:0097214 positive regulation of lysosomal membrane permeability biological_process GO:0097215 negative regulation of lysosomal membrane permeability biological_process GO:0097216 guanosine tetraphosphate binding molecular_function GO:0097217 sieve area cellular_component GO:0097218 sieve plate cellular_component GO:0097219 compound sieve plate cellular_component GO:0097220 simple sieve plate cellular_component GO:1900003 regulation of serine-type endopeptidase activity biological_process GO:1900004 negative regulation of serine-type endopeptidase activity biological_process GO:1900005 positive regulation of serine-type endopeptidase activity biological_process GO:1900006 positive regulation of dendrite development biological_process GO:1900007 regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging biological_process GO:1900008 negative regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging biological_process GO:1900009 positive regulation of extrachromosomal rDNA circle accumulation involved in replicative cell aging biological_process GO:1900010 regulation of corticotropin-releasing hormone receptor activity biological_process GO:1900011 negative regulation of corticotropin-releasing hormone receptor activity biological_process GO:1900012 positive regulation of corticotropin-releasing hormone receptor activity biological_process GO:1900015 regulation of cytokine production involved in inflammatory response biological_process GO:1900016 negative regulation of cytokine production involved in inflammatory response biological_process GO:1900017 positive regulation of cytokine production involved in inflammatory response biological_process GO:1900018 phosphorylation of RNA polymerase II C-terminal domain serine 5 residues involved in recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex biological_process GO:1900019 regulation of protein kinase C activity biological_process GO:1900020 positive regulation of protein kinase C activity biological_process GO:1900022 regulation of D-erythro-sphingosine kinase activity biological_process GO:1900023 positive regulation of D-erythro-sphingosine kinase activity biological_process GO:1900024 regulation of substrate adhesion-dependent cell spreading biological_process GO:1900025 negative regulation of substrate adhesion-dependent cell spreading biological_process GO:1900026 positive regulation of substrate adhesion-dependent cell spreading biological_process GO:1900027 regulation of ruffle assembly biological_process GO:1900028 negative regulation of ruffle assembly biological_process GO:1900029 positive regulation of ruffle assembly biological_process GO:1900030 regulation of pectin biosynthetic process biological_process GO:1900032 regulation of trichome patterning biological_process GO:1900033 negative regulation of trichome patterning biological_process GO:2001289 lipid X metabolic process biological_process OBSOLETIONS =========== None TERM MERGES =========== None TERM CHANGES ============ GO:0000155 : two-component sensor activity + relationship: part_of GO:0023014 GO:0003376 : sphingosine-1-phosphate signaling pathway - name: sphingolipid signaling pathway + name: sphingosine-1-phosphate signaling pathway - def: A series of molecular signals mediated by a sphingolipid. + def: A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription. + comment: Sphingosine-1-phosphate (S1P) can act both as an extracellular ligand for cell surface G-protein coupled receptors, and as an intracellular second messenger. GO:0003376 describes a pathway where S1P acts as an extracellular ligand. Where S1P acts within the cell to transmit a signal, consider instead 'intracellular signal transduction ; GO:0035556' or 'G-protein signaling, coupled to S1P second messenger (sphingosine kinase activating) ; GO:0001789'. - synonym: "sphingolipid signalling pathway" EXACT [GOC:mah] + synonym: "S1P-stimulated signal transduction pathway" EXACT [PMID:22001186] + synonym: "S1P receptor signaling pathway" EXACT [GOC:bf] + synonym: "S1P-activated GPCR signaling pathway" EXACT [GOC:bf] + synonym: "S1P signaling pathway" EXACT [GOC:bf] + synonym: "sphingolipid signaling pathway" BROAD [GOC:bf] + synonym: "S1P-activated G-protein coupled receptor signaling pathway" EXACT [GOC:bf] + synonym: "sphingolipid signalling pathway" BROAD [GOC:mah] + xref: Reactome:REACT_18416.2 "S1P-binding receptors bind S1P" - is_a: GO:0007165 + is_a: GO:0007186 GO:0003377 : regulation of apoptosis by sphingosine-1-phosphate signaling pathway - name: regulation of apoptosis by sphingolipid signaling pathway + name: regulation of apoptosis by sphingosine-1-phosphate signaling pathway - def: A series of molecular signals mediated by a sphingolipid that modulates the rate, frequency, or extent of apoptosis. + def: A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of apoptosis. - synonym: "regulation of apoptosis by sphingolipid signalling pathway" EXACT [GOC:mah] + synonym: "regulation of apoptosis by sphingolipid signaling pathway" BROAD [GOC:bf] + synonym: "regulation of apoptosis by sphingolipid signalling pathway" BROAD [GOC:mah] GO:0003378 : regulation of inflammatory response by sphingosine-1-phosphate signaling pathway - name: regulation of inflammatory response by sphingolipid signaling pathway + name: regulation of inflammatory response by sphingosine-1-phosphate signaling pathway - def: A series of molecular signals mediated by a sphingolipid that modulates the rate, frequency, or extent of the inflammatory response. + def: A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of the inflammatory response. - synonym: "regulation of inflammatory response by sphingolipid signalling pathway" EXACT [GOC:mah] + synonym: "regulation of inflammatory response by sphingolipid signaling pathway" BROAD [GOC:bf] + synonym: "regulation of inflammatory response by sphingolipid signalling pathway" BROAD [GOC:mah] GO:0004190 : aspartic-type endopeptidase activity + synonym: "aspartate protease activity" EXACT [GOC:mah, GOC:vw] GO:0004430 : 1-phosphatidylinositol 4-kinase activity - relationship: part_of GO:0046854 GO:0004702 : receptor signaling protein serine/threonine kinase activity + relationship: part_of GO:0023014 GO:0004716 : receptor signaling protein tyrosine kinase activity + relationship: part_of GO:0023014 GO:0004728 : receptor signaling protein tyrosine phosphatase activity + relationship: part_of GO:0023014 GO:0004897 : ciliary neurotrophic factor receptor activity - def: Combining with ciliary neurotrophic factor to initiate a change in cell activity. + def: Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal to initiate a change in cell activity. GO:0004923 : leukemia inhibitory factor receptor activity - def: Combining with leukemia inhibitory factor to initiate a change in cell activity. + def: Combining with leukemia inhibitory factor (LIF) and transmitting the signal to initiate a change in cell activity. GO:0004967 : glucagon receptor activity + relationship: part_of GO:0071377 GO:0004968 : gonadotropin-releasing hormone receptor activity - def: Combining with gonadotropin-releasing hormone to initiate a change in cell activity. + def: Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus. + synonym: "GnRH receptor activity" EXACT [] + relationship: part_of GO:0097211 GO:0007166 : cell surface receptor signaling pathway - name: cell surface receptor linked signaling pathway + name: cell surface receptor signaling pathway + synonym: "cell surface receptor linked signaling pathway" EXACT [GOC:bf] GO:0007249 : I-kappaB kinase/NF-kappaB cascade - xref: REACTOME:REACT_13696.1 "NF-kB is activated and signals survival, Homo sapiens" + xref: Reactome:REACT_13696.1 "NF-kB is activated and signals survival, Homo sapiens" GO:0007250 : activation of NF-kappaB-inducing kinase activity - synonym: "positive regulation of NF-kappaB-inducing kinase activity" EXACT [] + synonym: "activation of NIK activity" EXACT [GOC:bf] + synonym: "positive regulation of NF-kappaB-inducing kinase activity" BROAD [] GO:0007263 : nitric oxide mediated signal transduction - def: A series of molecular signals mediated by nitric oxide (NO). + def: Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms. + synonym: "nitric oxide signaling" EXACT [GOC:bf] - is_a: GO:0007165 + is_a: GO:0019932 GO:0008385 : IkappaB kinase complex + synonym: "trimeric IKK complex" EXACT [PMID:21173796] + synonym: "heterotrimeric IKK complex" EXACT [GOC:bf] GO:0015056 : corticotrophin-releasing factor receptor activity + relationship: part_of GO:0071376 GO:0016303 : 1-phosphatidylinositol-3-kinase activity + is_a: GO:0035004 + relationship: part_of GO:0036092 GO:0016307 : phosphatidylinositol phosphate kinase activity + synonym: "phosphatidylinositol monophosphate kinase activity" EXACT [GOC:bf] GO:0016316 : phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity + relationship: part_of GO:0036092 GO:0016500 : protein-hormone receptor activity + relationship: has_part GO:0017046 GO:0016503 : pheromone receptor activity + relationship: has_part GO:0005550 GO:0019221 : cytokine-mediated signaling pathway - def: Any series of molecular signals generated as a consequence of a cytokine binding to a cell surface receptor. + def: A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0019722 : calcium-mediated signaling - def: A series of molecular signals in which a cell uses calcium ions to convert a signal into a response. + def: Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. GO:0019932 : second-messenger-mediated signaling - def: A series of molecular signals in which an ion or small molecule is formed or released into the cytosol, thereby helping relay the signal within the cell. + def: Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell. GO:0019933 : cAMP-mediated signaling - def: A series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response. + def: Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell. GO:0019934 : cGMP-mediated signaling - def: A series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response. + def: Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell. GO:0019935 : cyclic-nucleotide-mediated signaling - def: A series of molecular signals in which a cell uses a cyclic nucleotide to convert an extracellular signal into a response. + def: Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell. GO:0023014 : signal transduction by phosphorylation - name: signal transduction via phosphorylation event + name: signal transduction by phosphorylation - def: The process in which a signal is conveyed via the transfer of one or more phosphate groups. + def: A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate. + synonym: "signal transduction via phosphorylation event" RELATED [GOC:bf] + is_a: GO:0016310 GO:0023015 : signal transduction by cis-phosphorylation - name: signal transduction via a cis-phosphorylation event + name: signal transduction by cis-phosphorylation - def: The process in which a signal is conveyed via the transfer of one or more phosphate groups by a kinase to a residue in the same kinase molecule. + def: A process in which the transfer of one or more phosphate groups by a kinase to a residue in the same kinase molecule transmits a signal. For example, ligand-binding can induce autophosphorylation of the activated receptor, creating binding sites for intracellular signaling molecules. - synonym: "signal transmission via auto-phosphorylation" EXACT [] + synonym: "signal transmission via auto-phosphorylation" RELATED [] + synonym: "signal transduction via a cis-phosphorylation event" RELATED [GOC:bf] GO:0023016 : signal transduction by trans-phosphorylation - name: signal transduction via a trans-phosphorylation event + name: signal transduction by trans-phosphorylation - def: The process in which a signal is conveyed via the transfer of one or more phosphate groups by a kinase to a residue in a different molecule. + def: A process in which the transfer of one or more phosphate groups by a kinase to a residue in a different molecule transmits a signal. + synonym: "signal transduction via a trans-phosphorylation event" RELATED [GOC:bf] GO:0023035 : CD40 signaling pathway - def: Any series of molecular signals generated as a consequence of the receptor CD40 binding to one of its physiological ligands. + def: A series of molecular signals initiated by the binding of the cell surface receptor CD40 to one of its physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0023045 : signal transduction by conformational transition - name: signal transduction via conformational transition + name: signal transduction by conformational transition - def: The process whereby a signal is passed on within a cell by triggering a conformational change in the molecule that is receiving the signal. + def: A process where induction of a conformational change in a molecule transmits a signal to that molecule. + synonym: "signal transduction via conformational transition" RELATED [GOC:bf] GO:0031530 : gonadotropin-releasing hormone receptor binding - def: Interacting selectively and non-covalently with a receptor for gonadotropin-releasing hormone, a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. + def: Interacting selectively and non-covalently with a receptor for gonadotropin-releasing hormone (GnRH), a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. + synonym: "GnRH receptor binding" EXACT [] GO:0033173 : calcineurin-NFAT signaling cascade - name: calcineurin-NFAT signaling pathway + name: calcineurin-NFAT signaling cascade - def: A series of molecular signals that results in activation of transcription by a member of the NFAT protein family as a consequence of NFAT dephosphorylation by activated calcineurin. The signaling is generated by a receptor binding a ligand, followed by activation of phospholipase C and the subsequent release of inositol trisphosphate, which in turn leads to an increase in intracellular calcium ion concentration that mediates the activation of calcineurin. + def: Any intracellular signal transduction in which the signal is passed on within the by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G-protein coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+). - synonym: "calcineurin-NFAT signalling pathway" EXACT [] + synonym: "calcineurin-NFAT signalling pathway" RELATED [] + synonym: "calcineurin-NFAT signaling pathway" RELATED [GOC:bf] GO:0033211 : adiponectin-mediated signaling pathway - def: A series of molecular signals generated as a consequence of adiponectin binding to a cell surface receptor. + def: A series of molecular signals initiated by the binding of adiponectin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0035004 : phosphatidylinositol 3-kinase activity - def: Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring to generate the 3-phosphoinositides: phosphatidylinositol-3-phosphate [PI(3)P], phosphatidylinositol-3,4-bisphosphate [PI(3,4)P2] and phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3]. + def: Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol 3-phosphate. This reaction is the addition of a phosphate group to phosphatidylinositol or one of its phosphorylated derivatives at the 3' position of the inositol ring. GO:0035005 : 1-phosphatidylinositol-4-phosphate 3-kinase activity + is_a: GO:0035004 GO:0035014 : phosphatidylinositol 3-kinase regulator activity + relationship: part_of GO:0043551 GO:0035689 : chemokine (C-C motif) ligand 5 signaling pathway - def: A series of molecular events generated as a consequence of the chemokine CCL5 binding to a cell surface receptor. + def: A series of molecular signals initiated by the binding of the chemokine CCL5 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0035722 : interleukin-12-mediated signaling pathway - def: A series of molecular signals generated as a consequence of interleukin-12 binding to a cell surface receptor. + def: A series of molecular signals initiated by the binding of interleukin-12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0038027 : apolipoprotein A-I-mediated signaling pathway - def: Any series of molecular signals initiated by the binding of apolipoprotein A-I to a cell surface receptor. + def: A series of molecular signals initiated by the binding of apolipoprotein A-I to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0038036 : sphingosine-1-phosphate receptor activity + relationship: part_of GO:0003376 GO:0039537 : suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway + synonym: "suppression by virus of host RIG-I/MDA5 signaling pathway" RELATED [GOC:bf] + synonym: "suppression by virus of host RIG-like receptor signaling pathway" RELATED [GOC:bf] + synonym: "suppression by virus of host RIG-like helicase signaling pathway" RELATED [GOC:bf] + synonym: "suppression by virus of host RLR signaling pathway" RELATED [GOC:bf] + synonym: "suppression by virus of host RIG-I-like receptor (RLR) signaling pathway" RELATED [GOC:bf] + is_a: GO:0075111 GO:0043812 : phosphatidylinositol-4-phosphate phosphatase activity + is_a: GO:0034596 GO:0043813 : phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity + relationship: part_of GO:0036092 GO:0046934 : phosphatidylinositol-4,5-bisphosphate 3-kinase activity + is_a: GO:0035004 GO:0048016 : inositol phosphate-mediated signaling - def: A series of molecular signals in which a cell uses a water-soluble inositol phosphate to convert a signal into a response. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6). + def: Any intracellular signal transduction in which the signal is passed on within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6). GO:0051448 : gonadotropin-releasing hormone binding - def: Interacting selectively and non-covalently with gonadotropin-releasing hormone, a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary and it is synthesized and released by the hypothalamus. + def: Interacting selectively and non-covalently with gonadotropin-releasing hormone (GnRH), a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus. + synonym: "GnRH binding" EXACT [] GO:0052742 : phosphatidylinositol kinase activity + relationship: part_of GO:0046854 GO:0052813 : phosphatidylinositol bisphosphate kinase activity + relationship: part_of GO:0046854 GO:0052866 : phosphatidylinositol phosphate phosphatase activity + synonym: "phosphoinositide phosphatase activity" EXACT [] GO:0060333 : interferon-gamma-mediated signaling pathway - def: A series of molecular events generated as a consequence of interferon-gamma binding to a cell surface receptor. + def: A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0061311 : cell surface receptor signaling pathway involved in heart development - name: cell surface receptor linked signaling pathway involved in heart development + name: cell surface receptor signaling pathway involved in heart development - def: Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell contributing to the progression of the heart over time. + def: Any series of molecular signals initiated by the binding of a receptor on the surface of a cell to a physiological ligand, which contributes to the progression of the heart over time. + synonym: "cell surface receptor linked signaling pathway involved in heart development" EXACT [GOC:bf] GO:0070098 : chemokine-mediated signaling pathway - def: A series of molecular signals generated as a consequence of a chemokine binding to a cell surface receptor. + def: A series of molecular signals initiated by the binding of a chemokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0070120 : ciliary neurotrophic factor-mediated signaling pathway - def: A series of molecular signals generated as a consequence of a ciliary neurotrophic factor binding to a cell surface receptor. + def: A series of molecular signals initiated by the binding of a ciliary neurotrophic factor (CNTF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0070498 : interleukin-1-mediated signaling pathway - def: A series of molecular signals generated as a consequence of interleukin-1 binding to a cell surface receptor. + def: A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GO:0070884 : regulation of calcineurin-NFAT signaling cascade - name: regulation of calcineurin-NFAT signaling pathway + name: regulation of calcineurin-NFAT signaling cascade - def: Any process that modulates the frequency, rate or extent of signaling via the calcineurin-NFAT signaling pathway. + def: Any process that modulates the frequency, rate or extent of the calcineurin-NFAT signaling cascade. - synonym: "regulation of calcineurin-NFAT signalling pathway" EXACT [GOC:mah] + synonym: "regulation of calcineurin-NFAT signaling pathway" RELATED [GOC:bf] + synonym: "regulation of calcineurin-NFAT signalling cascade" EXACT [GOC:mah] GO:0070885 : negative regulation of calcineurin-NFAT signaling cascade - name: negative regulation of calcineurin-NFAT signaling pathway + name: negative regulation of calcineurin-NFAT signaling cascade - def: Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the calcineurin-NFAT signaling pathway. + def: Any process that stops, prevents, or reduces the frequency, rate or extent of the calcineurin-NFAT signaling cascade. - synonym: "down regulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah] - synonym: "down-regulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah] - synonym: "inhibition of calcineurin-NFAT signaling pathway" NARROW [GOC:mah] - synonym: "downregulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah] - synonym: "negative regulation of calcineurin-NFAT signalling pathway" EXACT [GOC:mah] + synonym: "negative regulation of calcineurin-NFAT signaling pathway" RELATED [GOC:bf] + synonym: "inhibition of calcineurin-NFAT signaling cascade" NARROW [GOC:mah] + synonym: "down regulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah] + synonym: "negative regulation of calcineurin-NFAT signalling cascade" EXACT [GOC:mah] + synonym: "down-regulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah] + synonym: "termination of calcineurin-NFAT signaling cascade" NARROW [GOC:bf] + synonym: "downregulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah] GO:0070886 : positive regulation of calcineurin-NFAT signaling cascade - name: positive regulation of calcineurin-NFAT signaling pathway + name: positive regulation of calcineurin-NFAT signaling cascade - def: Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling pathway. + def: Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling cascade. - synonym: "up regulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah] - synonym: "positive regulation of calcineurin-NFAT signalling pathway" EXACT [GOC:mah] - synonym: "upregulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah] - synonym: "up-regulation of calcineurin-NFAT signaling pathway" EXACT [GOC:mah] - synonym: "stimulation of calcineurin-NFAT signaling pathway" NARROW [GOC:mah] - synonym: "activation of calcineurin-NFAT signaling pathway" NARROW [GOC:mah] + synonym: "upregulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah] + synonym: "activation of calcineurin-NFAT signaling cascade" NARROW [GOC:mah] + synonym: "up-regulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah] + synonym: "positive regulation of calcineurin-NFAT signaling pathway" RELATED [GOC:bf] + synonym: "positive regulation of calcineurin-NFAT signalling cascade" EXACT [GOC:mah] + synonym: "stimulation of calcineurin-NFAT signaling cascade" NARROW [GOC:mah] + synonym: "up regulation of calcineurin-NFAT signaling cascade" EXACT [GOC:mah] GO:2000819 : regulation of nucleotide-excision repair FILE STATS ========== Term counts for the old and new files Ontology Old file New file Change molecular function 9205 9208 +3 (9205 defined) (9208 defined) cellular component 2944 2949 +5 (2944 defined) (2949 defined) biological process 21765 21823 +58 (21765 defined) (21823 defined) Obsolete 1609 1609 0 (4.5% of total) (4.5% of total) (0.0%) Totals 33914 33980 +66 (+0.2%) 33914 (100.0%) defined 33980 (100.0%) defined 35523 inc. obs 35589 inc. obs