Gene Ontology Definition Changes
Files used:
- file 1 (old): 18:11:2011 17:55, cvs revision 1.2388
- file 2 (new): 24:11:2011 22:03, cvs revision 1.2403
- Database: unknown DB type, unknown DB release name
Terms with changed definitions
GO:0006915 : apoptotic process
(was apoptosis)
OLD: A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell.
NEW: A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathways) which typically lead to rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. The process ends when the cell has died. The process is divided into a signaling pathway phase and into an execution phase, which is triggered by the former.
GO:0007165 : signal transduction
OLD: The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal, e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell, and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
NEW: The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
GO:0007166 : cell surface receptor linked signaling pathway
OLD: Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell.
NEW: A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
GO:0007186 : G-protein coupled receptor signaling pathway
OLD: Any series of molecular signals initiated by an extracellular signal combining with a receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription.
NEW: Any series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription.
GO:0007532 : regulation of mating-type specific transcription, DNA-dependent
(was regulation of transcription, mating-type specific)
OLD: Any mating-type specific process that modulates the frequency, rate or extent of transcription.
NEW: Any mating-type specific process that modulates the frequency, rate or extent of cellular DNA-dependent transcription.
GO:0008219 : cell death
OLD: A biological process that results in permanent cessation of all vital functions of a cell.
NEW: Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as \"apoptotic bodies\"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo.
GO:0012501 : programmed cell death
OLD: Cell death resulting from activation of endogenous cellular processes.
NEW: A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
GO:0031931 : TORC1 complex
OLD: A protein complex that contains the TOR (target of rapamycin) serine/threonine kinase and mediates temporal control of cell growth via regulation of translation, transcription, ribosome biogenesis, nutrient transport, and autophagy. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p; in mammals the complex contains orthologs of the yeast proteins.
NEW: A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p.
GO:0031932 : TORC2 complex
OLD: A protein complex that contains the TOR (target of rapamycin) serine/threonine kinase and mediates spatial control of cell growth via regulation of actin cytoskeleton polarization. In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p; in mammals the complex contains orthologs of the yeast proteins.
NEW: A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p.
GO:0034505 : tooth mineralization
OLD: The process in which calcium salts are deposited into calcareous tooth structures such as dental enamel, dentine and cementum.
NEW: The process in which calcium salts are deposited into calcareous tooth structures such as dental enamel, dentin and cementum.
GO:0038023 : signaling receptor activity
OLD: Receiving an extracellular or intracellular signal and transmitting the signal to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
NEW: Receiving a signal and transmitting the signal in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
GO:0042475 : odontogenesis of dentin-containing tooth
(was odontogenesis of dentine-containing tooth)
OLD: The process whose specific outcome is the progression of a dentine-containing tooth over time, from its formation to the mature structure. A dentine-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and are composed mainly of dentine, a dense calcified substance, covered by a layer of enamel.
NEW: The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel.
GO:0042981 : regulation of apoptotic process
(was regulation of apoptosis)
OLD: Any process that modulates the occurrence or rate of cell death by apoptosis.
NEW: Any process that modulates the occurrence or rate of cell death by apoptotic process.
GO:0043065 : positive regulation of apoptotic process
(was positive regulation of apoptosis)
OLD: Any process that activates or increases the frequency, rate or extent of cell death by apoptosis.
NEW: Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
GO:0043066 : negative regulation of apoptotic process
(was negative regulation of apoptosis)
OLD: Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptosis.
NEW: Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
0 annotations
GO:0045894 : negative regulation of mating-type specific transcription, DNA-dependent
(was negative regulation of transcription, mating-type specific)
OLD: Any mating-type specific process that stops, prevents or reduces the rate of transcription.
NEW: Any mating-type specific process that stops, prevents or reduces the rate of cellular DNA-dependent transcription.
GO:0045895 : positive regulation of mating-type specific transcription, DNA-dependent
(was positive regulation of transcription, mating-type specific)
OLD: Any mating-type specific process that activates or increases the rate of transcription.
NEW: Any mating-type specific process that activates or increases the rate of cellular DNA-dependent transcription.
GO:0046848 : hydroxyapatite binding
OLD: Interacting selectively and non-covalently with hydroxyapatite, the calcium phosphate mineral of formula Ca10(PO4)6(OH)2 found both in rocks of nonorganic origin and as a component of bone and dentine.
NEW: Interacting selectively and non-covalently with hydroxyapatite, the calcium phosphate mineral of formula Ca10(PO4)6(OH)2 found both in rocks of nonorganic origin and as a component of bone and dentin.
0 annotations
GO:0060790 : tooth placode formation
OLD: The developmental process in which the tooth placode forms. An tooth placode is a thickening of the ectoderm that will give rise to the tooth bud.
NEW: The developmental process in which the tooth placode forms. A tooth placode is a thickening of the ectoderm that will give rise to the tooth bud.
GO:0061364 : apoptotic process involved in luteolysis
(was apoptosis involved in luteolysis)
OLD: The process of apoptosis that contributes to luteolysis.
NEW: The apoptotic process that contributes to luteolysis.
0 annotations
GO:0070468 : dentin secretion
(was dentine secretion)
OLD: The regulated release by odontoblasts of the extracellular matrix constituents, including collagen, that form the basis of dentine.
NEW: The regulated release by odontoblasts of the extracellular matrix constituents, including collagen, that form the basis of dentin.
GO:0071895 : odontoblast differentiation
OLD: The process in which a relatively unspecialized cell of neural crest origin acquires the specialized features of an odontoblast, a cell on the outer surface of the dental pulp whose biological function is the creation of dentine.
NEW: The process in which a relatively unspecialized cell of neural crest origin acquires the specialized features of an odontoblast, a cell on the outer surface of the dental pulp whose biological function is the creation of dentin.
GO:0090034 : regulation of chaperone-mediated protein complex assembly
(was regulation of cellular chaperone-mediated protein complex assembly)
OLD: Any process that modulates the frequency, rate, or extent of cellular chaperone-mediated protein complex assembly. Cellular chaperone-mediated protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell, mediated by chaperone molecules that do not form part of the finished complex.
NEW: Any process that modulates the frequency, rate, or extent of chaperone-mediated protein complex assembly. Chaperone-mediated protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex.
GO:0090035 : positive regulation of chaperone-mediated protein complex assembly
(was positive regulation of cellular chaperone-mediated protein complex assembly)
OLD: Any process that increases the frequency, rate, or extent of cellular chaperone-mediated protein complex assembly. Cellular chaperone-mediated protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell, mediated by chaperone molecules that do not form part of the finished complex.
NEW: Any process that increases the frequency, rate, or extent of chaperone-mediated protein complex assembly. Chaperone-mediated protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex.