Gene Ontology Definition Changes

2 / 2 direct

GO:0001586 : Gi/o-coupled serotonin receptor activity

(was 5-HT1 receptor activity)

OLD: A serotonin receptor activity that acts via coupling to Gi/Go to initiate a change in cell activity.
NEW: Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels.

2 / 2 direct

GO:0001587 : Gq/11-coupled serotonin receptor activity

(was 5-HT2 receptor activity)

OLD: A serotonin receptor activity that acts via coupling to G11/q to initiate a change in cell activity.
NEW: Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels.

0 annotations

GO:0001626 : nociceptin receptor activity

(was nociceptin/orphanin-FQ receptor activity)

OLD: Combining with the peptide nociceptin/orphanin-FQ to initiate a change in cell activity.
NEW: Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein.

0 annotations

GO:0004979 : beta-endorphin receptor activity

OLD: Combining with beta-endorphin to initiate a change in cell activity.
NEW: Combining with beta-endorphin, and transmitting the signal across the membrane by activating an associated G-protein. Beta-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor proopiomelanocortin (POMC).

84 / 19 direct

GO:0004985 : opioid receptor activity

OLD: Combining with an opioid, any narcotic derived from or resembling opium, to initiate a change in cell activity.
NEW: Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein.

123 / 119 direct

GO:0004993 : serotonin receptor activity

OLD: Combining with the biogenic amine serotonin, a neurotransmitter and hormone found in vertebrates, invertebrates and plants, to initiate a change in cell activity.
NEW: Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.

43 / 38 direct

GO:0004995 : tachykinin receptor activity

OLD: Combining with tachykinin to initiate a change in cell activity.
NEW: Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein.

130 / 130 direct

GO:0008158 : hedgehog receptor activity

OLD: Combining with a hedgehog protein to initiate a change in cell activity.
NEW: Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity.

328 / 107 direct

GO:0016708 : oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

OLD: Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen is incorporated into one donor.
NEW: Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen are incorporated into one donor.