Gene Ontology Ontology Comparison Report ========================== Files used: - file 1 (old): go-2011-11-12.obo; date: 08:11:2011 17:10; CVS revision: 1.2378 - file 2 (new): go-2011-11-19.obo; date: 18:11:2011 17:55; CVS revision: 1.2388 NEW TERMS ========= ID name namespace GO:0038046 enkephalin receptor activity molecular_function GO:0038047 morphine receptor activity molecular_function GO:0038048 dynorphin receptor activity molecular_function GO:0072693 protein targeting to prospore membrane biological_process GO:0097184 response to azide biological_process GO:0097185 cellular response to azide biological_process GO:2001227 quercitrin binding molecular_function OBSOLETIONS =========== GO:0001619, lysosphingolipid and lysophosphatidic acid receptor activity (molecular_function) Consider: GO:0038036, GO:0070915 GO:0004986, delta-opioid receptor activity (molecular_function) This term was made obsolete because the receptor is defined based on its pharmacological properties. Consider: GO:0038046 GO:0004987, kappa-opioid receptor activity (molecular_function) This term was made obsolete because the receptor is defined based on its pharmacological properties. Consider: GO:0038048 GO:0004988, mu-opioid receptor activity (molecular_function) This term was made obsolete because the receptor is defined based on its pharmacological properties. Consider: GO:0004979, GO:0038046, GO:0038047 GO:0015051, X-opioid receptor activity (molecular_function) This term was made obsolete because the receptor is defined based on its pharmacological properties. Consider: GO:0001626 GO:0045233, natural killer cell receptor activity (molecular_function) This term was made obsolete because the receptor is defined based on its cellular expression pattern, and the definition is inaccurate: receptors on natural killer cells can either activate or inhibit natural killer (NK) cell-mediated cytotoxicity. Consider: GO:0002769, GO:0004888, GO:0030101 TERM MERGES =========== None TERM CHANGES ============ GO:0000755 : cytogamy - synonym: "zygote formation" NARROW [] + synonym: "zygote formation" RELATED [] GO:0000916 : contractile ring contraction involved in cell cycle cytokinesis - synonym: "cytokinesis, contractile ring contraction" EXACT [GOC:dph, GOC:tb] - synonym: "contractile ring constriction" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] + synonym: "cytokinesis, contractile ring contraction" BROAD [GOC:dph, GOC:tb] + synonym: "contractile ring constriction" BROAD [GOC:ascb_2009, GOC:dph, GOC:tb] GO:0001071 : nucleic acid binding transcription factor activity + relationship: part_of GO:2001141 GO:0001586 : Gi/o-coupled serotonin receptor activity - name: 5-HT1 receptor activity + name: Gi/o-coupled serotonin receptor activity - def: A serotonin receptor activity that acts via coupling to Gi/Go to initiate a change in cell activity. + def: Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels. + synonym: "5-HT1 receptor activity" EXACT [GOC:bf] + synonym: "serotonin receptor activity, coupled via Gi/o" EXACT [GOC:bf] GO:0001587 : Gq/11-coupled serotonin receptor activity - name: 5-HT2 receptor activity + name: Gq/11-coupled serotonin receptor activity - def: A serotonin receptor activity that acts via coupling to G11/q to initiate a change in cell activity. + def: Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels. + synonym: "5-HT2 receptor activity" BROAD [GOC:bf] + synonym: "serotonin receptor activity, coupled via Gq/11" EXACT [GOC:bf] GO:0001619 : lysosphingolipid and lysophosphatidic acid receptor activity - is_a: GO:0045125 + is_obsolete: true + consider: GO:0038036 + consider: GO:0070915 GO:0001626 : nociceptin receptor activity - name: nociceptin/orphanin-FQ receptor activity + name: nociceptin receptor activity - def: Combining with the peptide nociceptin/orphanin-FQ to initiate a change in cell activity. + def: Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein. + synonym: "orphanin-FQ receptor activity" EXACT [GOC:bf] + synonym: "X-opioid receptor activity" RELATED [GOC:bf] + synonym: "OFQ receptor activity" EXACT [PR:000012940] + synonym: "nociceptin/orphanin-FQ receptor activity" EXACT [GOC:bf] - is_a: GO:0004930 + is_a: GO:0004985 GO:0004953 : icosanoid receptor activity + relationship: has_part GO:0050542 GO:0004969 : histamine receptor activity + relationship: has_part GO:0051381 GO:0004979 : beta-endorphin receptor activity - def: Combining with beta-endorphin to initiate a change in cell activity. + def: Combining with beta-endorphin, and transmitting the signal across the membrane by activating an associated G-protein. Beta-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor proopiomelanocortin (POMC). + synonym: "mu-opioid receptor activity" RELATED [GOC:bf] + is_a: GO:0004985 + relationship: has_part GO:0031626 GO:0004985 : opioid receptor activity - def: Combining with an opioid, any narcotic derived from or resembling opium, to initiate a change in cell activity. + def: Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein. GO:0004986 : delta-opioid receptor activity - def: Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of delta-opioid receptors, including the activity of enkephalins as ligands. + def: OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of delta-opioid receptors, including the activity of enkephalins as ligands. + comment: This term was made obsolete because the receptor is defined based on its pharmacological properties. - is_a: GO:0004985 + is_obsolete: true + consider: GO:0038046 GO:0004987 : kappa-opioid receptor activity - def: Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of kappa-opioid receptors, including high affinity for dynorphins. + def: OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of kappa-opioid receptors, including high affinity for dynorphins. + comment: This term was made obsolete because the receptor is defined based on its pharmacological properties. - is_a: GO:0004985 + is_obsolete: true + consider: GO:0038048 GO:0004988 : mu-opioid receptor activity - def: Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of mu-opioid receptors, including high affinity for enkephalins and beta-endorphin but low affinity for dynorphins. + def: OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of mu-opioid receptors, including high affinity for enkephalins and beta-endorphin but low affinity for dynorphins. + comment: This term was made obsolete because the receptor is defined based on its pharmacological properties. - is_a: GO:0004985 + is_obsolete: true + consider: GO:0004979 + consider: GO:0038046 + consider: GO:0038047 GO:0004993 : serotonin receptor activity - def: Combining with the biogenic amine serotonin, a neurotransmitter and hormone found in vertebrates, invertebrates and plants, to initiate a change in cell activity. + def: Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. + relationship: has_part GO:0051378 GO:0004995 : tachykinin receptor activity - def: Combining with tachykinin to initiate a change in cell activity. + def: Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein. GO:0005055 : laminin receptor activity + relationship: has_part GO:0043236 GO:0005220 : inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity + relationship: has_part GO:0070679 GO:0006351 : transcription, DNA-dependent + synonym: "transcription regulator activity" RELATED [] GO:0006352 : transcription initiation, DNA-dependent + synonym: "transcription initiation factor activity" RELATED [] GO:0006353 : transcription termination, DNA-dependent + synonym: "transcription termination factor activity" RELATED [] GO:0006360 : transcription from RNA polymerase I promoter + synonym: "RNA polymerase I transcription factor activity" RELATED [] GO:0006362 : transcription elongation from RNA polymerase I promoter + synonym: "RNA polymerase I transcription elongation factor activity" RELATED [] GO:0006363 : termination of RNA polymerase I transcription + synonym: "RNA polymerase I transcription termination factor activity" RELATED [] GO:0006366 : transcription from RNA polymerase II promoter + synonym: "RNA polymerase II transcription factor activity" RELATED [] GO:0006368 : transcription elongation from RNA polymerase II promoter + synonym: "RNA polymerase II transcription elongation factor activity" RELATED [] GO:0006369 : termination of RNA polymerase II transcription + synonym: "RNA polymerase II transcription termination factor activity" RELATED [] GO:0006383 : transcription from RNA polymerase III promoter + synonym: "RNA polymerase III transcription factor activity" RELATED [] GO:0006385 : transcription elongation from RNA polymerase III promoter + synonym: "RNA polymerase III transcription elongation factor activity" RELATED [] GO:0006386 : termination of RNA polymerase III transcription + synonym: "RNA polymerase III transcription termination factor activity" RELATED [] GO:0007338 : single fertilization - synonym: "zygote biosynthesis" BROAD [] - synonym: "zygote formation" BROAD [] + synonym: "zygote formation" RELATED [] + synonym: "zygote biosynthesis" RELATED [] GO:0008158 : hedgehog receptor activity - def: Combining with a hedgehog protein to initiate a change in cell activity. + def: Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity. GO:0015051 : X-opioid receptor activity - def: Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of X-opioid receptors. + def: OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of X-opioid receptors. + comment: This term was made obsolete because the receptor is defined based on its pharmacological properties. - is_a: GO:0004985 + is_obsolete: true + consider: GO:0001626 GO:0016708 : oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor - def: Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen is incorporated into one donor. + def: Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen are incorporated into one donor. GO:0021724 : inferior raphe nucleus development + synonym: "inferior central nucleus development" BROAD [] + synonym: "posterior raphe nucleus development" BROAD [] GO:0021725 : superior raphe nucleus development + synonym: "anterior raphe nucleus development" BROAD [] + synonym: "superior central nucleus development" BROAD [] GO:0031554 : regulation of transcription termination, DNA-dependent + synonym: "transcription antiterminator activity" RELATED [] GO:0032784 : regulation of transcription elongation, DNA-dependent + synonym: "transcription elongation regulator activity" RELATED [] GO:0032785 : negative regulation of transcription elongation, DNA-dependent + synonym: "negative transcription elongation regulator activity" RELATED [] GO:0032786 : positive regulation of transcription elongation, DNA-dependent + synonym: "positive transcription elongation regulator activity" RELATED [] GO:0045233 : natural killer cell receptor activity - def: A receptor found on the surface of natural killer cells which binds Class I MHC antigens and is required for activation of NK activity. It belongs to the Ly49i family. + def: OBSOLETE. A receptor found on the surface of natural killer cells which binds Class I MHC antigens and is required for activation of NK activity. It belongs to the Ly49i family. + comment: This term was made obsolete because the receptor is defined based on its cellular expression pattern, and the definition is inaccurate: receptors on natural killer cells can either activate or inhibit natural killer (NK) cell-mediated cytotoxicity. - is_a: GO:0004888 + is_obsolete: true + consider: GO:0002769 + consider: GO:0004888 + consider: GO:0030101 GO:0045892 : negative regulation of transcription, DNA-dependent + synonym: "transcription repressor activity" RELATED [] GO:0045893 : positive regulation of transcription, DNA-dependent + synonym: "transcription activator activity" RELATED [] GO:0055119 : relaxation of cardiac muscle - is_a: GO:0055118 GO:0071555 : cell wall organization + is_a: GO:0016043 GO:0072661 : protein targeting to plasma membrane - is_a: GO:0006605 + is_a: GO:0006612 FILE STATS ========== Term counts for the old and new files Ontology Old file New file Change molecular function 9142 9140 -2 (9142 defined) (9140 defined) cellular component 2922 2922 (2922 defined) (2922 defined) biological process 21588 21591 +3 (21588 defined) (21591 defined) Obsolete 1597 1603 +6 (4.5% of total) (4.5% of total) (+0.4%) Totals 33652 33653 +7 (0.0%) 33652 (100.0%) defined 33653 (100.0%) defined 35249 inc. obs 35256 inc. obs