Gene Ontology Definition Changes
Files used:
- file 1 (old): 14:10:2011 16:31, cvs revision 1.2327
- file 2 (new): 21:10:2011 10:06, cvs revision 1.2341
- Database: unknown DB type, unknown DB release name
Terms with changed definitions
GO:0001608 : G-protein coupled nucleotide receptor activity
(was nucleotide receptor activity, G-protein coupled)
OLD: Receiving a nucleotide or nucleotide derivative, and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity.
NEW: Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
GO:0001609 : G-protein coupled adenosine receptor activity
(was adenosine receptor activity, G-protein coupled)
OLD: Combining with adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity.
NEW: Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
GO:0001637 : G-protein coupled chemoattractant receptor activity
(was G-protein chemoattractant receptor activity)
OLD: Combining with a chemoattractant peptide to initiate a G-protein mediated change in cell activity.
NEW: Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
GO:0001640 : adenylate cyclase inhibiting metabotropic glutamate receptor activity
OLD: A G-protein coupled receptor that binds glutamate and inhibits adenylate cyclase activity.
NEW: Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity.
0 annotations
GO:0001647 : G-protein coupled cytokinin receptor activity
OLD: Combining with a cytokinin to initiate a change in cell activity. The receptor is G-protein coupled.
NEW: Combining with cytokinin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
GO:0001664 : G-protein coupled receptor binding
(was G-protein-coupled receptor binding)
OLD: Interacting selectively and non-covalently with a G-protein-coupled receptor.
NEW: Interacting selectively and non-covalently with a G-protein coupled receptor.
GO:0004889 : acetylcholine-activated cation-selective channel activity
(was nicotinic acetylcholine-activated cation-selective channel activity)
OLD: Catalysis of the transmembrane transfer of a cation by a channel that acts as a nicotinic acetylcholine receptor, and opens upon binding acetylcholine.
NEW: Catalysis of the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine.
GO:0004930 : G-protein coupled receptor activity
OLD: A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.
NEW: Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
GO:0004935 : adrenergic receptor activity
OLD: Combining with epinephrine or norepinephrine to initiate a change in cell activity.
NEW: Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex.
GO:0005892 : acetylcholine-gated channel complex
(was nicotinic acetylcholine-gated receptor-channel complex)
OLD: A protein complex that acts as an acetylcholine receptor, and forms a transmembrane channel through which ions may pass in response to ligand binding. The complex is a homo- or heteropentamer of subunits that are members of a neurotransmitter receptor superfamily.
NEW: A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding.
GO:0007186 : G-protein coupled receptor signaling pathway
(was G-protein coupled receptor protein signaling pathway)
OLD: The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand.
NEW: Any series of molecular signals initiated by an extracellular signal combining with a receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription.
GO:0007197 : inhibition of adenylate cyclase activity by G-protein coupled acetylcholine receptor signaling pathway
(was inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway)
OLD: The series of molecular signals generated as a consequence of a muscarinic acetylcholine receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP.
NEW: The series of molecular signals generated as a consequence of a G-protein coupled acetylcholine receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP.
GO:0007207 : activation of phospholipase C activity by G-protein coupled acetylcholine receptor signaling pathway
(was activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway)
OLD: The series of molecular signals generated as a consequence of a muscarinic acetylcholine receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate.
NEW: The series of molecular signals generated as a consequence of a G-protein coupled acetylcholine receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate.
GO:0007213 : G-protein coupled acetylcholine receptor signaling pathway
(was muscarinic acetylcholine receptor signaling pathway)
OLD: The series of molecular signals generated as a consequence of a muscarinic acetylcholine receptor binding to one of its physiological ligands; muscarinic acetylcholine receptors activate inhibitory G proteins and can be activated by the fungal alkaloid muscarine.
NEW: Any series of molecular signals initiated by an acetylcholine receptor on the surface of the target cell binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription.
GO:0008020 : G-protein coupled photoreceptor activity
OLD: A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light.
NEW: Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
GO:0008227 : G-protein coupled amine receptor activity
OLD: A receptor that binds an extracellular amine and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers.
NEW: Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
GO:0008528 : G-protein coupled peptide receptor activity
(was peptide receptor activity, G-protein coupled)
OLD: Combining with an extracellular or intracellular peptide to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state.
NEW: Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
GO:0016907 : G-protein coupled acetylcholine receptor activity
OLD: Combining with acetylcholine to initiate a change in cell activity via activation of a G protein.
NEW: Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
0 annotations
GO:0031789 : G-protein coupled acetylcholine receptor binding
(was muscarinic acetylcholine receptor binding)
OLD: Interacting selectively and non-covalently with a muscarinic acetylcholine receptor.
NEW: Interacting selectively and non-covalently with a G-protein coupled acetylcholine receptor.
0 annotations
GO:0033282 : protein C inhibitor-acrosin complex
OLD: A heterodimeric protein complex of protein C inhibitor and acrosin; complex formation inhibits the protease activity of acrosin.
NEW: A heterodimeric protein complex of protein C inhibitor (SERPINA5) and acrosin; formation of the complex inhibits the protease activity of acrosin.
0 annotations
GO:0038022 : G-protein coupled olfactory receptor activity
(was olfactory receptor activity, G-protein coupled)
OLD: Combining with an odorant and transmitting the signal to a heterotrimeric G-protein complex, to initiate a change in cell activity in response to detection of smell.
NEW: Combining with an odorant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
GO:0045028 : G-protein coupled purinergic nucleotide receptor activity
(was purinergic nucleotide receptor activity, G-protein coupled)
OLD: Combining with a purine nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity.
NEW: Combining with a purine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.
GO:0045125 : bioactive lipid receptor activity
OLD: Combining with a bioactive lipid to initiate a change in cell activity. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes.
NEW: Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes.
GO:0071340 : skeletal muscle acetylcholine-gated channel clustering
(was skeletal muscle nicotinic acetylcholine receptor clustering)
OLD: The accumulation of acetylcholine receptors (AChRs) in a narrow, central region of muscle fibers, in apposition to nerve terminals.
NEW: The accumulation of acetylcholine-gated cation channels in a narrow, central region of muscle fibers, in apposition to nerve terminals.
GO:0071553 : G-protein coupled pyrimidinergic nucleotide receptor activity
(was pyrimidinergic nucleotide receptor activity, G-protein coupled)
OLD: Combining with a pyrimidine nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity.
NEW: Combining with a pyrimidine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.