Gene Ontology Definition Changes

2 / 2 direct

GO:0001566 : non-kinase phorbol ester receptor activity

OLD: Phorbol ester/diacylglycerol binding proteins that do not have intrinsic kinase activity.
NEW: Combining with a phorbol ester and transmitting the signal by a mechanism independent of kinase activity.

1 / 1 direct

GO:0001571 : non-tyrosine kinase fibroblast growth factor receptor activity

OLD: A receptor belonging to the FGFR family but lacking the tyrosine kinase domain.
NEW: Combining with fibroblast growth factor (FGF) and transmitting the signal by a mechanism independent of tyrosine kinase activity.

218 / direct

GO:0001608 : nucleotide receptor activity, G-protein coupled

OLD: A GPCR that binds a nucleotide or nucleotide derivative as its ligand.
NEW: Receiving a nucleotide or nucleotide derivative, and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity.

14 / 14 direct

GO:0001618 : viral receptor activity

OLD: Combining with a virus component to initiate a change in cell activity.
NEW: Combining with a virus component and mediating entry of the virus into the cell.

6 / 6 direct

GO:0004873 : asialoglycoprotein receptor activity

OLD: The mediation of the endocytosis of plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed; recognizes the terminal galactose and N-acetylgalactosamine units; the complex of receptor and ligand is internalized and transported to a sorting organelle where disassociation occurs, the receptor being recycled to the cell membrane.
NEW: Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N-acetylgalactosamine units of the asialoglycoprotein, the receptor-ligand complex is internalized and transported to a sorting organelle where disassociation occurs before the receptor is recycled to the cell membrane.

4 / 4 direct

GO:0004874 : aryl hydrocarbon receptor activity

OLD: Combining with an aryl hydrocarbon to initiate a change in cell activity.
NEW: Combining with an aryl hydrocarbon to initiate a change in cell activity. The aryl hydrocarbon receptor is a ligand-activated transcription factor which translocates to the nucleus to activate transcription upon ligand-binding.

8 / 8 direct

GO:0004998 : transferrin receptor activity

OLD: Combining with transferrin to initiate a change in cell activity.
NEW: Combining selectively with transferrin, and delivering transferrin into the cell via endocytosis. Transferrin is a major iron carrier protein in vertebrates.

74 / 74 direct

GO:0005041 : low-density lipoprotein receptor activity

OLD: Combining with a low-density lipoprotein particle to initiate a change in cell activity.
NEW: Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein into the cell via endocytosis.

551 / 551 direct

GO:0005044 : scavenger receptor activity

OLD: Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand to initiate a change in cell activity. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs). Following ligand binding, scavenger receptors can mediate intracellular signaling and/or ligand internalization.
NEW: Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs).

1 / 1 direct

GO:0008196 : vitellogenin receptor activity

OLD: Combining with vitellogenin to initiate a change in cell activity.
NEW: Receiving vitellogenin, and delivering vitellogenin into the cell via endocytosis.

406 / 406 direct

GO:0009307 : DNA restriction-modification system

OLD: Any process that protect an organism from invading foreign DNA by methylation of self DNA at specific sequences and nucleolytic cleavage of unmethylated foreign DNA.
NEW: Any process that protects an organism from invading foreign DNA by methylation of self DNA at specific sequences and nucleolytic cleavage of unmethylated foreign DNA.

0 annotations

GO:0016964 : alpha-2 macroglobulin receptor activity

OLD: Combining with an alpha-2 macroglobulin to initiate a change in cell activity.
NEW: Combining with alpha-2 macroglobulin and delivering alpha-2 macroglobulin into the cell via receptor-mediated endocytosis.

10 / 4 direct

GO:0020007 : apical complex

OLD: Protruding complex at the anterior end of some life cycle stages of all apicomplexan parasites, involved in both the attachment and penetration of the host cell by the parasite.
NEW: A group of cytoskeletal structures and associated membrane-bounded organelles found at the anterior end of adult obligate intracellular protozoan parasites in the phylum Apicomplexa. The apical complex is involved in attachment to and penetration of the host cell, and in parasite proliferation.

5 / direct

GO:0030226 : apolipoprotein receptor activity

OLD: Combining with an apolipoprotein, the protein component of a lipoprotein, to initiate a change in cell activity.
NEW: Combining with an apolipoprotein to initiate a change in cell activity.

109 / 9 direct

GO:0030228 : lipoprotein particle receptor activity

OLD: Combining with a lipoprotein particle to initiate a change in cell activity. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids.
NEW: Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids.

20 / 20 direct

GO:0030229 : very-low-density lipoprotein particle receptor activity

OLD: Combining with a very-low-density lipoprotein particle to initiate a change in cell activity.
NEW: Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis.

0 annotations

GO:0030745 : dimethylhistidine N-methyltransferase activity

OLD: Catalysis of the reaction: S-adenosyl-L-methionine + NN1,NN1-dimethyl-L-histidine = S-adenosyl-L-homocysteine + NN1,NN1,NN1-trimethyl-L-histidine.
NEW: Catalysis of the reaction: S-adenosyl-L-methionine + N-alpha,N-alpha-dimethyl-L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine.

0 annotations

GO:0033568 : lactoferrin receptor activity

OLD: Combining with lactoferrin to initiate a change in cell activity.
NEW: Combining with lactoferrin and delivering lactoferrin into the cell via endocytosis. Lactoferrin is an iron-binding glycoprotein which binds ferric iron most efficiently at low pH.

5 / 5 direct

GO:0034188 : apolipoprotein A-I receptor activity

OLD: Combining with apolipoprotein A-I to initiate a change in cell activity.
NEW: Combining with apolipoprotein A-I and transmitting the signal to initiate a change in cell activity.

7 / 7 direct

GO:0070287 : ferritin receptor activity

OLD: Combining with ferritin, an iron-storing protein complex, to initiate a change in cell activity.
NEW: Combining with ferritin, and delivering ferritin into the cell via endocytosis.

6 / 6 direct

GO:0070506 : high-density lipoprotein particle receptor activity

OLD: Combining with a high-density lipoprotein particle to initiate a change in cell activity.
NEW: Combining with a high-density lipoprotein particle and delivering the high-density lipoprotein into the cell via endocytosis.

15 / direct

GO:0071963 : establishment or maintenance of cell polarity regulating cell shape

OLD: Any cellular process that results in the specification, formation or maintenance of a polarized intracellular organization or cell growth patterns that regulates the shaping of a cell.
NEW: Any cellular process that results in the specification, formation or maintenance of a polarized intracellular organization or cell growth patterns that regulate the shape of a cell.

0 annotations

GO:0097108 : hedgehog family protein binding

(was hedgehog binding)

OLD: Interacting selectively and non-covalently with a hedgehog protein, a signaling protein involved in development.
NEW: Interacting selectively and non-covalently with a member of the hedgehog protein family, signaling proteins involved in development.

0 annotations

GO:0097109 : neuroligin family protein binding

(was neuroligin binding)

OLD: Interacting selectively and non-covalently with neuroligin, a neuronal cell surface protein on the postsynaptic membrane that mediates synapse formation between neurons.
NEW: Interacting selectively and non-covalently with a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation.