Ontology Comparison Report ========================== Files used: - file 1 (old): go-2011-06-25.obo; date: 24:06:2011 15:09; CVS revision: 1.2067 - file 2 (new): go-2011-07-02.obo; date: 01:07:2011 14:52; CVS revision: 1.2074 NEW TERMS ========= ID name namespace GO:0002189 ribose phosphate diphosphokinase complex cellular_component GO:0035915 pore complex assembly in other organism biological_process GO:0035916 modulation of calcium channel activity in other organism biological_process GO:0035917 negative regulation of calcium channel activity in other organism biological_process GO:0035918 negative regulation of voltage-gated calcium channel activity in other organism biological_process GO:0035919 negative regulation of low voltage-gated calcium channel activity in other organism biological_process GO:0035920 negative regulation of high voltage-gated calcium channel activity in other organism biological_process GO:0038021 leptin receptor activity molecular_function GO:0038022 olfactory receptor activity, G-protein coupled molecular_function GO:0097089 methyl-branched fatty acid metabolic process biological_process GO:2000794 regulation of epithelial cell proliferation involved in lung morphogenesis biological_process GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis biological_process GO:2000796 Notch signaling pathway involved in negative regulation of venous endothelial cell fate commitment biological_process GO:2000797 regulation of amniotic stem cell differentiation biological_process GO:2000798 negative regulation of amniotic stem cell differentiation biological_process GO:2000799 positive regulation of amniotic stem cell differentiation biological_process GO:2000800 regulation of endocardial cushion to mesenchymal transition involved in heart valve formation biological_process GO:2000801 negative regulation of endocardial cushion to mesenchymal transition involved in heart valve formation biological_process GO:2000802 positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation biological_process GO:2000803 endosomal signal transduction biological_process OBSOLETIONS =========== None TERM MERGES =========== GO:0008095, inositol-1,4,5-trisphosphate receptor activity was merged into GO:0005220, inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity TERM CHANGES ============ GO:0004984 : olfactory receptor activity - def: Combining with airborne compounds to initiate a change in cell activity. These receptors are used for the sense of smell. + def: Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell. + synonym: "odorant receptor activity" EXACT [PMID:19135896, PMID:21041441] - is_a: GO:0004930 + is_a: GO:0004888 + relationship: part_of GO:0050911 GO:0005044 : scavenger receptor activity - def: Combining with acetylated low-density lipoproteins, advanced glycation end products, or other polyanionic ligands to initiate a change in cell activity. + def: Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand to initiate a change in cell activity. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs). Following ligand binding, scavenger receptors can mediate intracellular signaling and/or ligand internalization. - synonym: "macrophage receptor activity" EXACT [] + synonym: "macrophage receptor activity" NARROW [] GO:0005220 : inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity + alt_id: GO:0008095 - def: Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate has been bound by the channel complex or one of its constituent parts. + def: Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts. + synonym: "IP3 receptor activity" EXACT [] + synonym: "InsP3 receptor" EXACT [GOC:bf] + synonym: "inositol-1,4,5-trisphosphate receptor activity" EXACT [] - is_a: GO:0008095 + is_a: GO:0004872 + relationship: part_of GO:0048016 GO:0007172 : signal complex assembly - def: The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell. Complex formation involves dimerization of a receptor protein tyrosine kinase followed by the association of several different intracellular signaling molecules with the cytoplasmic tails of the receptors. + def: The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell. + is_a: GO:0009966 - relationship: part_of GO:0007169 GO:0008527 : taste receptor activity + relationship: part_of GO:0050912 GO:0015469 : channel-forming toxin activity - consider: GO:0046931 + consider: GO:0035915 GO:0031585 : regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity - name: regulation of inositol-1,4,5-triphosphate receptor activity + name: regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity - def: Any process that modulates the frequency, rate or extent of the activity of the IP3 receptor. + def: Any process that modulates the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel. + synonym: "regulation of inositol-1,4,5-triphosphate receptor activity" EXACT [GOC:signaling] - intersection_of: regulates GO:0008095 + intersection_of: regulates GO:0005220 - relationship: regulates GO:0008095 + relationship: regulates GO:0005220 GO:0031586 : negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity - name: negative regulation of inositol-1,4,5-trisphosphate receptor activity + name: negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity - def: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the IP3 receptor. + def: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel. + synonym: "negative regulation of inositol 1,4,5-trisphosphate receptor activity" EXACT [GOC:signaling] - intersection_of: negatively_regulates GO:0008095 + intersection_of: negatively_regulates GO:0005220 - relationship: negatively_regulates GO:0008095 + relationship: negatively_regulates GO:0005220 GO:0031587 : positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity - name: positive regulation of inositol-1,4,5-trisphosphate receptor activity + name: positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity - def: Any process that activates or increases the frequency, rate or extent of the activity of the IP3 receptor. + def: Any process that activates or increases the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel. + synonym: "positive regulation of inositol-1,4,5-trisphosphate receptor activity" EXACT [GOC:bf] - intersection_of: positively_regulates GO:0008095 + intersection_of: positively_regulates GO:0005220 - relationship: positively_regulates GO:0008095 + relationship: positively_regulates GO:0005220 GO:0033038 : bitter taste receptor activity + relationship: part_of GO:0001580 GO:0033039 : salty taste receptor activity + relationship: part_of GO:0001583 GO:0033040 : sour taste receptor activity + relationship: part_of GO:0001581 GO:0033041 : sweet taste receptor activity + relationship: part_of GO:0001582 GO:0033042 : umami taste receptor activity + relationship: part_of GO:0046535 GO:0033210 : leptin-mediated signaling pathway - def: A series of molecular signals generated as a consequence of leptin binding to a cell surface receptor. + def: A series of molecular signals generated as a consequence of leptin binding to a cell surface receptor. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. + is_a: GO:0044320 GO:0043113 : receptor clustering - relationship: part_of GO:0007172 GO:0046931 : pore complex assembly - synonym: "channel-forming toxin activity" RELATED [] GO:0060501 : positive regulation of epithelial cell proliferation involved in lung morphogenesis + is_a: GO:2000794 FILE STATS ========== Term counts for the old and new files Ontology Old file New file Change molecular function 9023 9024 +1 (9023 defined) (9024 defined) cellular component 2855 2856 +1 (2855 defined) (2856 defined) biological process 20983 21000 +17 (20982 defined) (20999 defined) Obsolete 1559 1559 0 (4.5% of total) (4.5% of total) (0.0%) Totals 32861 32880 +19 (+0.1%) 32860 (100.0%) defined 32879 (100.0%) defined 34420 inc. obs 34439 inc. obs