# molecular_function
20141129: Eumetazoa_PTN001220492 has function JUN kinase kinase activity (GO:0008545)
20141129: Eumetazoa_PTN001220507 has function JUN kinase kinase activity (GO:0008545)
20141124: Eukaryota_PTN000684494 has function MAP kinase kinase activity (GO:0004708)
# cellular_component
20141129: Eukaryota_PTN000684494 located in intracellular (GO:0005622)
# biological_process
20141205: Eutheria_PTN000684587 participates in neuron differentiation (GO:0030182)
20141205: Chordata_PTN000684580 participates in regulation of stress-activated MAPK cascade (GO:0032872)
20141205: Fungi_PTN001220544 participates in cellular hyperosmotic response (GO:0071474)
20141205: Fungi_PTN001220544 participates in activation of MAPK activity involved in osmosensory signaling pathway (GO:0000169)
20141129: Eumetazoa_PTN001220492 participates in activation of JUN kinase activity (GO:0007257)
20141129: Eumetazoa_PTN001220507 participates in activation of JUN kinase activity (GO:0007257)
20141129: Eukaryota_PTN000684494 participates in activation of MAPK activity (GO:0000187)
# Notes



Annotation inferences using phylogenetic trees

The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).