# molecular_function
20150414: Euteleostomi_PTN000668396 has function phosphatidylinositol 3-kinase catalytic subunit binding (GO:0036313)
20150414: Eumetazoa_PTN001208528 lost/modified serine-type peptidase activity (GO:0008236) capacity
20150414: Eumetazoa_PTN001208617 lost/modified serine-type peptidase activity (GO:0008236) capacity
20150414: Eukaryota_PTN000718629 has function serine-type peptidase activity (GO:0008236)
20150414: Bilateria_PTN001208567 has function serine-type endopeptidase activity (GO:0004252)
# cellular_component
20150414: Euteleostomi_PTN000668417 located in extracellular space (GO:0005615)
20150414: Euteleostomi_PTN000668442 located in extracellular space (GO:0005615)
# biological_process
20150414: Euteleostomi_PTN000668442 participates in morphogenesis of a branching epithelium (GO:0061138)
20150414: Euteleostomi_PTN000668442 participates in positive regulation of cell proliferation (GO:0008284)
20150414: Euteleostomi_PTN000668442 participates in hepatocyte growth factor receptor signaling pathway (GO:0048012)
20150414: Euteleostomi_PTN000668396 participates in negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)
20150414: Euteleostomi_PTN000668396 participates in negative regulation of phosphatidylinositol 3-kinase activity (GO:0043553)
20150414: Eutheria_PTN000668522 participates in positive regulation of apoptotic process (GO:0043065)
20150414: Bilateria_PTN001208567 participates in proteolysis (GO:0006508)
# Notes



Annotation inferences using phylogenetic trees

The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).