# molecular_function 20140815: root_PTN000756675 has function chaperone binding (GO:0051087) 20140815: root_PTN000756675 has function unfolded protein binding (GO:0051082) # cellular_component 20140815: root_PTN001180601 located in chloroplast envelope (GO:0009941) 20140815: root_PTN001180601 located in chloroplast thylakoid membrane (GO:0009535) 20140815: LUCA_PTN001531278 located in cytoplasm (GO:0005737) 20140815: Fungi_PTN001180221 located in nucleus (GO:0005634) 20140815: Fungi_PTN001180221 located in cytosol (GO:0005829) 20140815: Embryophyta_PTN001531554 located in chloroplast (GO:0009507) 20140815: Eukaryota_PTN001180473 located in endoplasmic reticulum (GO:0005783) 20140815: Eumetazoa_PTN001180543 located in mitochondrion (GO:0005739) 20140815: mitosporic Nakaseomyces_PTN001531405 located in endoplasmic reticulum (GO:0005783) 20140815: Eukaryota_PTN001180179 located in mitochondrion (GO:0005739) 20140815: Eukaryota_PTN001531327 located in cytosol (GO:0005829) 20140815: Eukaryota_PTN001180323 located in cytosol (GO:0005829) 20140815: root_PTN001180601 located in chloroplast (GO:0009507) # biological_process 20140815: Eumetazoa_PTN001180543 participates in regulation of apoptotic process (GO:0042981) 20140815: Eumetazoa_PTN001180543 participates in mitochondrion organization (GO:0007005) 20140815: mitosporic Nakaseomyces_PTN001531405 participates in ER-associated ubiquitin-dependent protein catabolic process (GO:0030433) 20140815: mitosporic Nakaseomyces_PTN001531405 participates in protein folding in endoplasmic reticulum (GO:0034975) 20140815: root_PTN000756675 participates in protein refolding (GO:0042026) # Notes MAF: Large scale mitochondrial membrane lovcation in Yeast have too many false positives to be trusted. Apart from "refolding" (propagated to the root thanks to ECOLI._dnaJ), no other clear exp evidences. Even location is difficult to propagate in such a tree. Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).