# molecular_function
20150408: Eukaryota_PTN000360213 has function ubiquitin conjugating enzyme binding (GO:0031624)
20150408: Eukaryota_PTN000360213 has function ubiquitin protein ligase activity (GO:0061630)
# cellular_component
20150408: Eumetazoa_PTN001018176 located in intrinsic component of endoplasmic reticulum membrane (GO:0031227)
20150408: Tetrapoda_PTN000360279 located in nucleus (GO:0005634)
20150408: Eukaryota_PTN000360213 located in intracellular (GO:0005622)
# biological_process
20150408: Mammalia_PTN000360260 participates in serotonin metabolic process (GO:0042428)
20150408: Mammalia_PTN000360260 participates in norepinephrine metabolic process (GO:0042415)
20150408: Mammalia_PTN000360260 participates in adult behavior (GO:0030534)
20150408: Eukaryota_PTN000360213 participates in positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)
20150408: Eukaryota_PTN000360213 participates in protein polyubiquitination (GO:0000209)
# Notes



Annotation inferences using phylogenetic trees

The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).