# molecular_function
20141113: Eukaryota_PTN000043893 has function protein kinase inhibitor activity (GO:0004860)
# cellular_component
20141113: Eukaryota_PTN000043893 located in cytoplasm (GO:0005737)
# biological_process
20141114: root_PTN000043896 participates in negative regulation of insulin receptor signaling pathway (GO:0046627)
20141113: Eukaryota_PTN000043893 participates in cytokine-mediated signaling pathway (GO:0019221)
20141113: Eukaryota_PTN000043893 participates in negative regulation of protein kinase activity (GO:0006469)
20141113: Eumetazoa_PTN000822858 participates in negative regulation of epidermal growth factor receptor signaling pathway (GO:0042059)
20141113: Eukaryota_PTN000043893 participates in negative regulation of JAK-STAT cascade (GO:0046426)
# Notes
Nov 14 2014 - HM


Annotation inferences using phylogenetic trees

The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).