Annotation inferences using phylogenetic treesThe goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).
This is a transcription factor protein family. The Opisthokonts members are well annotated to transcription factor activity; Plant members do not have EXP annotations.

MF:
- sequence-specific DNA binding transcription factor activity GO:0003700: propagated to Opisthokonts PTN799249; other transcription factor related terms and DNA binding terms are not propagated. I feel that it is more appropriate to propagate GO:0003700 than other more specific terms, GO:0003700 is also the most widely used term for annotations in this family.

CC:
- nucleus: propagate to the root.
- cytoplasm: propagate to the root.

BP:
- cellular response to cAMP: to PTN5018.
- cullular response to gonadotropin stimulus: to PTN5018.
- glomerular visceral epithelial cell differentiation: to PTN5064.
- negative regulation of apoptotic process: to PTN5018.
- myelination: to PTN5091.
- negative regulation of cell proliferation: to PTN5064.
- regulation of neuronal synaptic plasticity: to PTN5091.
- regulation of long-term neuronal synaptic plasticity: to PTN5019.
- skeletal muscle cell differentiation: to PTN5091 and PTN5019.