# molecular_function
20150313: Eukaryota_PTN000000763 has function RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978)
20150313: Eukaryota_PTN000000763 has function transcription regulatory region DNA binding (GO:0044212)
20150313: Eukaryota_PTN000000763 has function RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001077)
# cellular_component
20150313: Eukaryota_PTN000000763 located in cytoplasm (GO:0005737)
20150313: Eukaryota_PTN000000763 located in nucleus (GO:0005634)
# biological_process
20150313: Euteleostomi_PTN000000819 participates in melanocyte differentiation (GO:0030318)
20150313: Eukaryota_PTN000000763 participates in positive regulation of transcription from RNA polymerase II promoter (GO:0045944)
# Notes



Annotation inferences using phylogenetic trees

The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).