# HISTORY 05 Oct 2016: Saved by mfeuerma using Paint 2.22 # molecular_function 20161005: root_PTN000048554 has function mevalonate kinase activity (GO:0004496) 20161005: Eukaryota_PTN002214956 has LOST/MODIFIED function mevalonate kinase activity (GO:0004496) 20161005: Eukaryota_PTN002214956 has function glucuronokinase activity (GO:0047940) # cellular_component 20161005: root_PTN000048554 is found in cytosol (GO:0005829) # biological_process 20161005: root_PTN000048554 participates in isopentenyl diphosphate biosynthetic process, mevalonate pathway (GO:0019287) 20161005: Eukaryota_PTN002214956 does NOT participate in isopentenyl diphosphate biosynthetic process, mevalonate pathway (GO:0019287) 20161005: Eukaryota_PTN002214956 participates in cell wall biogenesis (GO:0042546) 20161005: root_PTN000048554 participates in sterol metabolic process (GO:0016125) 20161005: Eukaryota_PTN002214956 does NOT participate in sterol metabolic process (GO:0016125) 20161005: Fungi_PTN000825284 participates in ergosterol biosynthetic process (GO:0006696) 20161005: Eumetazoa_PTN000825262 participates in cholesterol biosynthetic process (GO:0006695) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).