# HISTORY 28 Oct 2016: Saved by pgaudet using Paint 2.25 # molecular_function 20161028: root_PTN000530450 has function oxidoreductase activity, acting on a sulfur group of donors (GO:0016667) 20161028: node_PTN002456842 has function glutathione-disulfide reductase activity (GO:0004362) 20161028: cellular organisms_PTN001487220 has function thioredoxin-disulfide reductase activity (GO:0004791) 20161028: node_PTN002456842 has LOST/MODIFIED function thioredoxin-disulfide reductase activity (GO:0004791) # cellular_component 20161028: root_PTN000530450 is found in cytoplasm (GO:0005737) 20161028: Eukaryota_PTN002456829 is found in mitochondrion (GO:0005739) 20161028: Eukaryota_PTN000530453 is found in mitochondrion (GO:0005739) 20161028: Viridiplantae_PTN000530610 is found in mitochondrion (GO:0005739) 20161028: Viridiplantae_PTN000530610 is found in chloroplast stroma (GO:0009570) 20161028: Opisthokonta_PTN002456835 is found in mitochondrion (GO:0005739) # biological_process 20161028: root_PTN000530450 participates in cellular oxidant detoxification (GO:0098869) 20161028: root_PTN000530450 participates in response to oxygen radical (GO:0000305) 20161028: root_PTN000530450 participates in cell redox homeostasis (GO:0045454) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).