# HISTORY 18 Oct 2016: Saved by krc using Paint 2.25 # molecular_function 20161018: root_PTN001091980 has function malate synthase activity (GO:0004474) 20161018: root_PTN001091980 has function magnesium ion binding (GO:0000287) # cellular_component 20161018: root_PTN001091980 is found in cytosol (GO:0005829) # biological_process 20161018: root_PTN001091980 participates in glyoxylate catabolic process (GO:0009436) 20100707: Mycobacterium tuberculosis H37Rv_P9WK17 to coenzyme A metabolic process (GO:0015936) was challenged because This paper, PMID:16877713, seems to be saying that coenzyme A is bound as part of the malate synthase complex, but it seems to be a cofactor. I don't see any indication that this enzyme is doing anything with respect to the actual biosynthesis or metabolism of coenzyme A. # CHALLENGED 18 Oct 2016: Mycobacterium tuberculosis H37Rv_P9WK17 annotation to coenzyme A metabolic process (GO:0015936) from [PMID:16877713] was challenged # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).