# HISTORY 26 Apr 2016: Updated by: TOUCHUP-v1.15 21 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function # cellular_component # biological_process # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES Only the human TEX40 protein is annotated, and only to "cytoplasm" from GO_REF:0000054 "Gene Ontology annotation based on curation of intracellular localizations of expressed fusion proteins in living cells." about LIFEdb, 2013, a database that was created to manage the experimental data produced by the German Cancer Research Institute (DKFZ) and its collaborators, from work on cDNAs contained in the German cDNA Consortium collection, and which is based on large scale localization of fusion proteins. I have not propagated an annotation based solely on this large scale experiment. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).