# HISTORY 26 Apr 2016: Updated by: TOUCHUP-v1.15 20 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function # cellular_component # biological_process # PRUNED 26 Apr 2016: Pentapetalae_PTN002219154 has been pruned from tree # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES 20 Mar 2016: Pentapetalae_PTN002219154 has been pruned from tree MSA looks terrible across the diamond node, so suspect it is not true. Pruning plant sequences and leaving insect sequences in this family. No annotations as it looks like the D. melanogaster annotation is from an HTP paper. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).