# HISTORY
26 Apr 2016: Updated by: TOUCHUP-v1.15
19 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20140912: Bilateria_PTN001268347 has function K63-linked polyubiquitin binding (GO:0070530) 

# cellular_component
20140729: Bilateria_PTN001268347 is found in nucleus (GO:0005634) 
20140729: Bilateria_PTN001268347 is found in cytoplasm (GO:0005737) 
20140728: Euteleostomi_PTN000774283 is found in cytoplasmic, membrane-bounded vesicle (GO:0016023) 
20140728: Euteleostomi_PTN000774283 is found in Golgi apparatus (GO:0005794) 
20140729: Euteleostomi_PTN000774296 is found in IkappaB kinase complex (GO:0008385) 

# biological_process
20140729: Bilateria_PTN001268347 participates in regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122) 
20140728: Euteleostomi_PTN000774283 participates in protein targeting to Golgi (GO:0000042) 
20140728: Euteleostomi_PTN000774283 participates in Golgi ribbon formation (GO:0090161) 
20140729: Euteleostomi_PTN000774296 participates in positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
OPTN
Most studies of optineurin have focused on its binding partners and, to a lesser extent, possible functional properties. Optineurin interacts with adenovirus E3-14.7K , Huntington, RAB8, transcription factor IIIA , and myosin VI. siRNA studies have suggested that optineurin plays a role in Golgi integrity and the exocytosis of vesicular-stomatitis-virus G protein. Optineurin normally resides in the cytoplasm, but it has recently been shown to shuttle to the nucleus in NIH 3T3 cells stimulated with H2O2, although the biological significance of this is not yet known. Despite the enumeration of these individual activities, how optineurin might regulate cell functions is unclear.
PMID:15837803
http://www.ncbi.nlm.nih.gov/pubmed/15837803?dopt=Abstract
optineurin may link myosin VI to Rab8, as it has been suggested that it links huntingtin to Rab8. Optineurin as a myosin VI–binding partner present at the Golgi complex, plays a role in post-Golgi membrane traffic to the cell surface
PMID:21040294
Unraveling the Golgi ribbon
Golgi membranes in vertebrate cells are integrated into a single compact entity termed the Golgi ribbon that is normally localized in the perinuclear area
So propagate the Golgi ribbon formation to upper clay Euteleostomi_PTN000774283
Ikbkg:
PMID:16858400
The IkappaB kinase (IKK) complex is composed of three subunits, IKKalpha, IKKbeta, and IKKgamma (NEMO). While IKKalpha and IKKbeta are highly similar catalytic subunits, both capable of IkappaB phosphorylation in vitro, IKKgamma is a regulatory subunit.
There is a mouse paper that is not been annotated yet, that talks about Optn and Ikbkg
PMID:17702576
Ikbkg , the regulatory subunit of the IkappaB kinase (IKK) that activates NF-kappaB, is essential for NF-kappaB activation. Optineurin competitively antagonized Ikbkg's binding to polyUb RIP, and its overexpression inhibited TNFalpha-induced NF-kappaB activation.
microRNA silencing of optineurin resulted in markedly enhanced TNFalpha-induced NF-kappaB activity.
Propagate to the root:
Regulation of I-kappaB kinase/NF-KappaB signaling
Will annotate the mouse paper and come back paint negative regulation of I-kappaB kinase/NF-KappaB signaling to the upper clay Euteleostomi_PTN000774283
Will also find and add a Enzyme regulator activity to Ikbkg, and propagate to the lower clay.
LN

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).