# HISTORY 26 Apr 2016: Updated by: TOUCHUP-v1.15 19 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150806: Eukaryota_PTN001259483 has function pre-mRNA 5'-splice site binding (GO:0030627) # cellular_component 20150806: Eukaryota_PTN001259483 is found in prespliceosome (GO:0071010) 20150806: Eukaryota_PTN001259483 is found in commitment complex (GO:0000243) 20150806: Eukaryota_PTN001259483 is found in U1 snRNP (GO:0005685) # biological_process 20150806: Eukaryota_PTN001259483 participates in mRNA 5'-splice site recognition (GO:0000395) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES This family contains the U1 small nuclear ribonucleoprotein C subunit of the U1 snRNP, encoded by the SNRPC gene in vertebrates and the YHC1 gene in S. cerevisiae. The U1 snRNP is one the first snRNP to assemble onto the pre-mRNA, recognizing the 5' splice site (Wahl et al. 2009 PMID:19239890). # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).