# HISTORY 04 Aug 2016: Updated by: TOUCHUP-v1.21 # molecular_function 20160421: root_PTN000778111 has function 4 iron, 4 sulfur cluster binding (GO:0051539) 20160421: root_PTN000778111 has function quinolinate synthetase A activity (GO:0008987) # cellular_component 20160421: Eukaryota_PTN001254884 is found in chloroplast (GO:0009507) 20160421: Bacteria _PTN000778117 is found in cytosol (GO:0005829) # biological_process 20160421: root_PTN000778111 participates in 'de novo' NAD biosynthetic process from aspartate (GO:0034628) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).