# HISTORY 28 Mar 2016: Updated by: TOUCHUP-v1.15 18 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20151109: Eukaryota_PTN002001416 has function 3',5'-cyclic-GMP phosphodiesterase activity (GO:0047555) 20151109: Eukaryota_PTN002001416 has function 3',5'-cyclic-AMP phosphodiesterase activity (GO:0004115) # cellular_component # biological_process 20151109: Eukaryota_PTN002001416 participates in cGMP catabolic process (GO:0046069) 20151109: Eukaryota_PTN002001416 participates in cAMP catabolic process (GO:0006198) 20151109: Eukaryota_PTN002001416 participates in negative regulation of cAMP biosynthetic process (GO:0030818) 20151109: Eukaryota_PTN002001416 participates in negative regulation of cAMP-dependent protein kinase activity (GO:2000480) 20151109: Eukaryota_PTN002001416 participates in negative regulation of glucose mediated signaling pathway (GO:1902660) 20151109: Eukaryota_PTN002001416 participates in regulation of cAMP-mediated signaling (GO:0043949) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).