# HISTORY 28 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.12 18 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150930: Eukaryota_PTN002000154 contributes to function enzyme activator activity (GO:0008047) 20150930: Eukaryota_PTN002000154 has function signal transducer activity (GO:0004871) # cellular_component 20150930: Eukaryota_PTN002000154 is found in heterotrimeric G-protein complex (GO:0005834) 20150930: Eukaryota_PTN002000154 is found in cytoplasm (GO:0005737) # biological_process 20150930: Eukaryota_PTN002000154 participates in adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189) 20150930: Eukaryota_PTN002000154 participates in heterotrimeric G-protein complex cycle (GO:0031684) 20150930: Eukaryota_PTN002000154 participates in cAMP-mediated signaling (GO:0019933) 20150930: Dikarya_PTN002000156 participates in pheromone-dependent signal transduction involved in conjugation with cellular fusion (GO:0000750) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).