# HISTORY 28 Mar 2016: Updated by: TOUCHUP-v1.15 14 Mar 2016: Updated by: TOUCHUP-v1.12 18 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20151109: Fungi_PTN001998997 has function RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978) 20151109: Fungi_PTN001998997 has function copper ion binding (GO:0005507) 20151109: Fungi_PTN001998997 has function RNA polymerase II transcription factor activity, copper ion regulated core promoter proximal region sequence-specific binding (GO:0001202) # cellular_component 20151109: Fungi_PTN001998997 is found in nucleus (GO:0005634) # biological_process 20151109: Fungi_PTN001998997 participates in cellular copper ion homeostasis (GO:0006878) 20151109: Fungi_PTN001998997 participates in cellular iron ion homeostasis (GO:0006879) 20151109: Fungi_PTN001998997 participates in positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 20151109: Fungi_PTN001998997 participates in cellular response to acidic pH (GO:0071468) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).