# HISTORY 28 Mar 2016: Updated by: TOUCHUP-v1.15 18 Nov 2015: redistribution of PTN000701352 from PTHR24420 to PTHR26392 18 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150225: Eukaryota_PTN000701352 has function non-membrane spanning protein tyrosine kinase activity (GO:0004715) 20150414: Chordata_PTN001237949 has function MAP kinase kinase kinase activity (GO:0004709) # cellular_component 20150225: Eukaryota_PTN000701352 is found in extracellular region (GO:0005576) 20150414: Chordata_PTN001237949 is found in intracellular (GO:0005622) # biological_process 20150414: Chordata_PTN001237949 participates in activation of MAPKK activity (GO:0000186) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).