# HISTORY
28 Mar 2016: Updated by: TOUCHUP-v1.15
18 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20140729: Eukaryota_PTN000784925 has function protein serine/threonine kinase activity (GO:0004674) 

# cellular_component
20140729: Eukaryota_PTN000784925 is found in nucleus (GO:0005634) 
20140729: Eukaryota_PTN000784925 is found in cytoplasm (GO:0005737) 

# biological_process
20140729: Eukaryota_PTN000784925 participates in intracellular signal transduction (GO:0035556) 
20140729: node_PTN001563216 participates in positive regulation of NF-kappaB transcription factor activity (GO:0051092) 
20140730: node_PTN001563216 participates in toll-like receptor signaling pathway (GO:0002224) 
20140729: node_PTN001563216 participates in interleukin-1-mediated signaling pathway (GO:0070498) 
20140730: Euteleostomi_PTN000701380 participates in negative regulation of MAP kinase activity (GO:0043407) 
20140730: Tetrapoda_PTN000701420 participates in positive regulation of MAP kinase activity (GO:0043406) 
20140730: Tetrapoda_PTN000701420 participates in positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123) 
20140730: Tetrapoda_PTN000701420 participates in toll-like receptor 4 signaling pathway (GO:0034142) 
20140730: Ecdysozoa_PTN000701449 participates in Toll signaling pathway (GO:0008063) 
20140730: Euteleostomi_PTN000701356 participates in positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123) 
20140730: Pancrustacea_PTN001563255 participates in Toll signaling pathway (GO:0008063) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
The interleukin 1 mediated signaling pathway is only annotated to IRAK1-3, because IRAK4 is under a different clade and none of the sequences have a GO annotation of that term.

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).