# HISTORY 28 Mar 2016: Updated by: TOUCHUP-v1.15 18 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20140617: node_PTN000700357 has function receptor binding (GO:0005102) 20140617: node_PTN000700357 has function non-membrane spanning protein tyrosine kinase activity (GO:0004715) 20140729: Mammalia_PTN001231348 has function growth hormone receptor binding (GO:0005131) 20140728: Mammalia_PTN001231348 has function histone kinase activity (H3-Y41 specific) (GO:0035401) 20140729: Euteleostomi_PTN000701141 has function growth factor receptor binding (GO:0070851) 20140729: Euteleostomi_PTN000701141 has function hormone receptor binding (GO:0051427) 20140617: Opisthokonta_PTN001231474 has LOST/MODIFIED function receptor binding (GO:0005102) # cellular_component 20140618: node_PTN000700357 is found in extrinsic component of cytoplasmic side of plasma membrane (GO:0031234) # biological_process 20140728: node_PTN000700357 participates in peptidyl-tyrosine autophosphorylation (GO:0038083) 20140731: node_PTN000700357 participates in innate immune response (GO:0045087) 20140729: node_PTN000700357 participates in regulation of cell proliferation (GO:0042127) 20140728: node_PTN000700357 participates in transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 20140729: node_PTN000700357 participates in cell differentiation (GO:0030154) 20140730: Deuterostomia_PTN000700475 participates in cell adhesion (GO:0007155) 20140730: Deuterostomia_PTN000700475 participates in cytoskeleton organization (GO:0007010) 20140729: Deuterostomia_PTN000700475 participates in negative regulation of apoptotic process (GO:0043066) 20140730: Chordata_PTN001231249 participates in regulation of cell adhesion (GO:0030155) 20140731: Chordata_PTN001231249 participates in epidermal growth factor receptor signaling pathway (GO:0007173) 20140730: Chordata_PTN001231249 participates in angiogenesis (GO:0001525) 20140731: Deuterostomia_PTN000700775 participates in epidermal growth factor receptor signaling pathway (GO:0007173) 20140730: Deuterostomia_PTN000700775 participates in cell adhesion (GO:0007155) 20140730: Deuterostomia_PTN000700775 participates in chemotaxis (GO:0006935) 20140730: Deuterostomia_PTN000700775 participates in regulation of mast cell degranulation (GO:0043304) 20140730: Boreoeutheria_PTN000700801 participates in Fc-epsilon receptor signaling pathway (GO:0038095) 20140730: Euteleostomi_PTN000700361 participates in NK T cell differentiation (GO:0001865) 20140730: Amniota_PTN000700439 participates in tissue regeneration (GO:0042246) 20140731: Amniota_PTN000700439 participates in integrin-mediated signaling pathway (GO:0007229) 20140730: Amniota_PTN000700439 participates in regulation of platelet activation (GO:0010543) 20140730: Euteleostomi_PTN000700727 participates in signal transduction in response to DNA damage (GO:0042770) 20140731: Opisthokonta_PTN001231165 participates in cell migration (GO:0016477) 20140729: Mammalia_PTN000700628 participates in B cell differentiation (GO:0030183) 20140729: Mammalia_PTN000700628 participates in positive regulation of T cell proliferation (GO:0042102) 20140729: Mammalia_PTN000700628 participates in T cell homeostasis (GO:0043029) 20140729: Euteleostomi_PTN000700624 participates in tyrosine phosphorylation of STAT protein (GO:0007260) 20140729: Euteleostomi_PTN000700624 participates in erythrocyte differentiation (GO:0030218) 20140729: Euteleostomi_PTN000700624 participates in cytokine-mediated signaling pathway (GO:0019221) 20140729: Euteleostomi_PTN000700624 participates in regulation of apoptotic process (GO:0042981) 20140729: Euteleostomi_PTN000700624 participates in inflammatory response (GO:0006954) 20140729: Mammalia_PTN001231348 participates in regulation of cell adhesion (GO:0030155) 20140729: Euteleostomi_PTN000700673 participates in regulation of cytokine production (GO:0001817) 20140729: Euteleostomi_PTN000700673 participates in central nervous system development (GO:0007417) 20140729: Euteleostomi_PTN000700673 participates in regulation of Fc receptor mediated stimulatory signaling pathway (GO:0060368) 20140729: Euteleostomi_PTN000700673 participates in adherens junction organization (GO:0034332) 20140729: Euteleostomi_PTN000700478 participates in neutrophil activation involved in immune response (GO:0002283) 20140729: Euteleostomi_PTN000700478 participates in inflammatory response (GO:0006954) 20140729: Euteleostomi_PTN000700478 participates in positive regulation of alpha-beta T cell proliferation (GO:0046641) 20140729: Euteleostomi_PTN000700478 participates in B cell receptor signaling pathway (GO:0050853) 20140729: Euteleostomi_PTN000700478 participates in macrophage activation involved in immune response (GO:0002281) 20140729: Euteleostomi_PTN000700478 participates in positive regulation of mast cell degranulation (GO:0043306) 20140729: Euteleostomi_PTN000700478 participates in adaptive immune response (GO:0002250) 20140729: Euteleostomi_PTN000700478 participates in regulation of platelet aggregation (GO:0090330) 20140729: Euteleostomi_PTN000700478 participates in positive regulation of cell adhesion mediated by integrin (GO:0033630) 20140729: Euteleostomi_PTN000700478 participates in positive regulation of B cell differentiation (GO:0045579) 20140729: Euteleostomi_PTN000701087 participates in regulation of apoptotic process (GO:0042981) 20140731: Euteleostomi_PTN000701087 participates in cell migration (GO:0016477) 20140731: Euteleostomi_PTN000701087 participates in central nervous system development (GO:0007417) 20140731: Euteleostomi_PTN000701087 participates in T cell activation (GO:0042110) 20140731: Euteleostomi_PTN000701087 participates in T cell receptor signaling pathway (GO:0050852) 20140731: Euteleostomi_PTN000701141 participates in progesterone receptor signaling pathway (GO:0050847) 20140731: Euteleostomi_PTN000701141 participates in bone resorption (GO:0045453) 20140731: Euteleostomi_PTN000701141 participates in cell adhesion (GO:0007155) 20140731: Euteleostomi_PTN000701141 participates in negative regulation of intrinsic apoptotic signaling pathway (GO:2001243) 20140731: Euteleostomi_PTN000701141 participates in regulation of podosome assembly (GO:0071801) 20140731: Euteleostomi_PTN000701141 participates in epidermal growth factor receptor signaling pathway (GO:0007173) 20140731: Euteleostomi_PTN000701141 participates in negative regulation of extrinsic apoptotic signaling pathway (GO:2001237) 20140731: Euteleostomi_PTN000701141 participates in platelet-derived growth factor receptor signaling pathway (GO:0048008) 20140731: Euteleostomi_PTN000701141 participates in osteoclast development (GO:0036035) 20140731: Euteleostomi_PTN000701141 participates in central nervous system development (GO:0007417) 20140731: Euteleostomi_PTN000701141 participates in intracellular estrogen receptor signaling pathway (GO:0030520) 20140731: Euteleostomi_PTN000701141 participates in regulation of cell cycle (GO:0051726) 20140731: Euteleostomi_PTN001563156 participates in integrin-mediated signaling pathway (GO:0007229) 20140731: Euteleostomi_PTN001563156 participates in cell migration (GO:0016477) 20140731: Euteleostomi_PTN000701114 participates in T cell differentiation (GO:0030217) 20140731: Euteleostomi_PTN000701114 participates in B cell receptor signaling pathway (GO:0050853) 20140729: Amniota_PTN001231382 participates in regulation of apoptotic process (GO:0042981) 20140730: Euteleostomi_PTN000700963 participates in cytoskeleton organization (GO:0007010) 20140729: Euteleostomi_PTN000700963 participates in negative regulation of apoptotic process (GO:0043066) 20140730: Euteleostomi_PTN000700963 participates in regulation of podosome assembly (GO:0071801) 20140730: Euteleostomi_PTN000700963 participates in regulation of phagocytosis (GO:0050764) 20140730: Euteleostomi_PTN000701010 participates in chemotaxis (GO:0006935) 20140730: Euteleostomi_PTN000701010 participates in regulation of mast cell degranulation (GO:0043304) 20140731: Euteleostomi_PTN000701010 participates in central nervous system development (GO:0007417) 20140730: Euteleostomi_PTN000701010 participates in negative regulation of B cell proliferation (GO:0030889) 20140730: Euteleostomi_PTN000701010 participates in Fc receptor mediated stimulatory signaling pathway (GO:0002431) 20140729: Euteleostomi_PTN000701010 participates in tolerance induction to self antigen (GO:0002513) 20140730: Euteleostomi_PTN000701010 participates in cellular response to DNA damage stimulus (GO:0006974) 20140729: Euteleostomi_PTN000701010 participates in inflammatory response (GO:0006954) 20140730: Euteleostomi_PTN000701010 participates in regulation of platelet aggregation (GO:0090330) 20140730: Euteleostomi_PTN000701010 participates in platelet degranulation (GO:0002576) 20140730: Euteleostomi_PTN000701010 participates in positive regulation of dendritic cell apoptotic process (GO:2000670) 20140730: Euteleostomi_PTN000701010 participates in neuron projection development (GO:0031175) 20140730: Euteleostomi_PTN000701010 participates in dendritic cell differentiation (GO:0097028) 20140730: Euteleostomi_PTN000701010 participates in regulation of B cell apoptotic process (GO:0002902) 20140730: Euteleostomi_PTN000701010 participates in regulation of B cell receptor signaling pathway (GO:0050855) 20140730: Euteleostomi_PTN000701010 participates in cell migration (GO:0016477) 20140730: Euteleostomi_PTN000701010 participates in negative regulation of mast cell proliferation (GO:0070667) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES Human TNK2 has evidence for both Tyr and Ser kinase activity; however this is very unusual; do not propagate. # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).