# HISTORY 08 May 2016: Updated by: TOUCHUP-v1.18 18 Mar 2016: Updated by: TOUCHUP-v1.14 27 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20140207: root_PTN001225609 has function transcription factor activity, sequence-specific DNA binding (GO:0003700) # cellular_component # biological_process 20140207: root_PTN001225609 participates in regulation of transcription, DNA-templated (GO:0006355) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES root is a duplication. MF Triangulation supports assigning "sequence-specific DNA binding transcription factor activity (GO:0003700)" in root. This is rather low confidence but in the absence of other information it is nevertheless useful. CC **Cannot propagate nucleus to the root because there is a 'not' annotation to nucleolus. Needs to be fixed. This is due to HPA being annotated to 'nucleus not nucleolus' by HPA. BP Although there are 52 different BP annotated, only 3 are found more than once or twice: negative regulation of transcription from RNA polymerase II promoter negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated Therefore, propagated "regulation of transcription, DNA-templated" to root # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).