# HISTORY 27 Mar 2016: Updated by: TOUCHUP-v1.15 18 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20150217: Eukaryota_PTN001224574 has function G-protein coupled peptide receptor activity (GO:0008528) 20150217: Euteleostomi_PTN000757870 has function follicle-stimulating hormone receptor activity (GO:0004963) 20150217: Euteleostomi_PTN000689916 has function luteinizing hormone receptor activity (GO:0004964) 20150217: Euteleostomi_PTN000689893 has function thyroid-stimulating hormone receptor activity (GO:0004996) # cellular_component 20150217: Eukaryota_PTN001224574 is found in integral component of plasma membrane (GO:0005887) # biological_process 20150217: Eukaryota_PTN001224574 participates in adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189) 20150217: Eukaryota_PTN001224574 participates in hormone-mediated signaling pathway (GO:0009755) 20150217: Eukaryota_PTN001224574 participates in activation of adenylate cyclase activity (GO:0007190) 20150217: Euteleostomi_PTN000757870 participates in follicle-stimulating hormone signaling pathway (GO:0042699) 20150217: Euteleostomi_PTN000757870 participates in primary ovarian follicle growth (GO:0001545) 20150217: Euteleostomi_PTN000757870 participates in regulation of osteoclast differentiation (GO:0045670) 20150217: Euteleostomi_PTN000689916 participates in phospholipase C-activating G-protein coupled receptor signaling pathway (GO:0007200) 20150217: Euteleostomi_PTN000689916 participates in ovulation cycle process (GO:0022602) 20150217: Euteleostomi_PTN000689916 participates in development of primary male sexual characteristics (GO:0046546) 20150217: Euteleostomi_PTN000689893 participates in nervous system development (GO:0007399) 20150217: Euteleostomi_PTN000689893 participates in thyroid-stimulating hormone signaling pathway (GO:0038194) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).