# HISTORY
04 Aug 2016: Saved by suzi using Paint 2.22
27 Mar 2016: Updated by: TOUCHUP-v1.15
18 Mar 2016: Updated by: TOUCHUP-v1.14
08 May 2016: Updated by: TOUCHUP-v1.18

# molecular_function
20131118: root_PTN000684825 has function receptor signaling protein serine/threonine kinase activity (GO:0004702) 
20131122: Eumetazoa_PTN001220872 has function MAP kinase kinase activity (GO:0004708) 

# cellular_component
20131118: root_PTN000684825 is found in cytoplasm (GO:0005737) 

# biological_process
20131122: Eumetazoa_PTN001220668 participates in apoptotic process (GO:0006915) 
20131122: Eukaryota_PTN000685129 participates in mitotic cell cycle (GO:0000278) 
20131121: Bilateria_PTN000685295 participates in axonogenesis (GO:0007409) 
20131122: Bilateria_PTN000685295 participates in actin cytoskeleton organization (GO:0030036) 
20131119: Euteleostomi_PTN000685299 participates in regulation of apoptotic process (GO:0042981) 
20131121: Bilateria_PTN000685542 participates in apoptotic process (GO:0006915) 
20131121: Bilateria_PTN000685542 participates in regulation of cell differentiation (GO:0045595) 
20131122: Eukaryota_PTN001220664 participates in actin cytoskeleton organization (GO:0030036) 
20131119: Eumetazoa_PTN001220914 participates in hippo signaling (GO:0035329) 
20131119: Deuterostomia_PTN000686022 participates in negative regulation of canonical Wnt signaling pathway (GO:0090090) 
20131122: Opisthokonta_PTN001221166 does NOT participate in mitotic cell cycle (GO:0000278) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
The term is not propagated to PTN001221310, because the kinase activity is not detected based on literature.
All the biological process propagations are based on literatures. Only the cellular processes are propagated.
- cytokenesis and mitotic cell cycle are only shown in fungus under Eukaryota_PTN000685129. There is no evidence in multicellular animals. Therefore, lost is used to stop the propagation of those terms at Opisthokonta_PTN001221166
- response to stress (GO:0006950) seems to be found in almost all orthologous groups and all species (yeast, dicty, mammals, etc). It seems to be evolved very early. therefore, it is propagated to the root_PTN000684825

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).