# HISTORY 07 May 2016: Updated by: TOUCHUP-v1.18 18 Mar 2016: Updated by: TOUCHUP-v1.14 27 Mar 2016: Updated by: TOUCHUP-v1.15 # molecular_function 20150114: root_PTN000682064 has function protein serine/threonine kinase activity (GO:0004674) 20150114: Opisthokonta_PTN001219258 has function ribosomal protein S6 kinase activity (GO:0004711) 20150116: Opisthokonta_PTN001219224 has function histone kinase activity (H3-S10 specific) (GO:0035175) # cellular_component 20150114: root_PTN000682064 is found in nucleus (GO:0005634) 20150114: root_PTN000682064 is found in cytoplasm (GO:0005737) 20150114: Eukaryota_PTN000682243 is found in plasma membrane (GO:0005886) # biological_process 20150114: root_PTN000682064 participates in intracellular signal transduction (GO:0035556) 20150116: Amniota_PTN000682128 participates in cellular response to insulin stimulus (GO:0032869) 20150114: Opisthokonta_PTN001219224 participates in histone H3-S28 phosphorylation (GO:0043988) 20150114: Opisthokonta_PTN001219224 participates in positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 20150114: Opisthokonta_PTN001219224 participates in histone H3-S10 phosphorylation (GO:0043987) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).