# HISTORY 26 Oct 2016: Saved by pgaudet using Paint 2.25 # molecular_function 20161026: Eukaryota_PTN001963821 has function transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001227) 20161026: Eukaryota_PTN001963821 has function sequence-specific DNA binding (GO:0043565) 20161026: Eukaryota_PTN001963821 has function RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) # cellular_component 20161026: Eukaryota_PTN001963821 is found in nucleus (GO:0005634) # biological_process 20161026: Eukaryota_PTN001963821 participates in negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 20161026: Eukaryota_PTN001963821 participates in cell differentiation (GO:0030154) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).