# HISTORY 27 Mar 2016: Updated by: TOUCHUP-v1.15 18 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20151007: root_PTN001209376 has function oxidoreductase activity (GO:0016491) 20151007: Eukaryota_PTN000757302 has function C-22 sterol desaturase activity (GO:0000249) 20151007: Eukaryota_PTN001209305 has function sterol 14-demethylase activity (GO:0008398) 20151007: Eukaryota_PTN000669383 has function monooxygenase activity (GO:0004497) 20151007: Magnoliophyta_PTN000669512 has function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen (GO:0016709) 20151007: rosids_PTN001958088 has function (+)-abscisic acid 8'-hydroxylase activity (GO:0010295) 20151007: Magnoliophyta_PTN001209420 has function (+)-abscisic acid 8'-hydroxylase activity (GO:0010295) 20151007: Magnoliophyta_PTN001958145 has function steroid hydroxylase activity (GO:0008395) 20151007: Magnoliophyta_PTN001958145 has function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen (GO:0016709) 20151007: Magnoliophyta_PTN001958375 has function ent-kaurenoate oxidase activity (GO:0051777) 20151007: Magnoliophyta_PTN000669442 has function oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen (GO:0016709) 20151007: node_PTN001209360 has function monooxygenase activity (GO:0004497) 20151007: node_PTN001209360 has function heme binding (GO:0020037) 20151007: Bacteria _PTN001209364 has function steroid hydroxylase activity (GO:0008395) 20151007: Bacteria _PTN001209364 has function cholest-4-en-3-one 26-monooxygenase activity (GO:0036199) # cellular_component 20151007: Eukaryota_PTN001209305 is found in endoplasmic reticulum (GO:0005783) 20151007: Eukaryota_PTN001209305 is found in plasma membrane (GO:0005886) 20151007: Magnoliophyta_PTN001958007 is found in chloroplast envelope (GO:0009941) 20151007: Pentapetalae_PTN001958056 is found in chloroplast envelope (GO:0009941) 20151007: Pentapetalae_PTN001958056 is found in chloroplast thylakoid membrane (GO:0009535) 20151007: Magnoliophyta_PTN001958375 is found in endoplasmic reticulum (GO:0005783) 20151007: Pentapetalae_PTN001958522 is found in endoplasmic reticulum (GO:0005783) 20151007: node_PTN001209360 is found in plasma membrane (GO:0005886) # biological_process 20151007: root_PTN001209376 participates in sterol metabolic process (GO:0016125) 20151007: Eukaryota_PTN000757302 participates in sterol biosynthetic process (GO:0016126) 20151007: Eukaryota_PTN000669384 participates in ergosterol biosynthetic process (GO:0006696) 20151007: Eukaryota_PTN001209305 participates in sterol biosynthetic process (GO:0016126) 20151007: Fungi_PTN001209323 participates in ergosterol biosynthetic process (GO:0006696) 20151007: Opisthokonta_PTN001209306 participates in cholesterol biosynthetic process via 24,25-dihydrolanosterol (GO:0033488) 20151007: Pentapetalae_PTN001958056 participates in defense response (GO:0006952) 20151007: Pentapetalae_PTN001958056 participates in jasmonic acid biosynthetic process (GO:0009695) 20151007: Embryophyta_PTN001209423 participates in brassinosteroid biosynthetic process (GO:0016132) 20151007: Embryophyta_PTN001209423 participates in multicellular organism development (GO:0007275) 20151007: Embryophyta_PTN001209423 participates in brassinosteroid homeostasis (GO:0010268) 20151007: Magnoliophyta_PTN000669512 participates in abscisic acid metabolic process (GO:0009687) 20151007: Magnoliophyta_PTN001958375 participates in gibberellin biosynthetic process (GO:0009686) 20151007: Bacteria _PTN001209364 participates in cholesterol catabolic process (GO:0006707) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).