# HISTORY
27 Mar 2016: Updated by: TOUCHUP-v1.15
18 Mar 2016: Updated by: TOUCHUP-v1.14

# molecular_function
20141204: Eukaryota_PTN001208501 has function serine-type endopeptidase activity (GO:0004252) 

# cellular_component
20141204: Mammalia_PTN000760904 is found in extracellular space (GO:0005615) 
20141204: Mammalia_PTN000668264 is found in intracellular membrane-bounded organelle (GO:0043231) 
20141204: Mammalia_PTN000668264 is found in cytoplasm (GO:0005737) 
20141211: Boreoeutheria_PTN001208506 is found in azurophil granule (GO:0042582) 

# biological_process
20141204: Eukaryota_PTN001208501 participates in protein processing (GO:0016485) 
20141204: Mammalia_PTN000668264 participates in immune response (GO:0006955) 

# WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED

# NOTES
MAF:endopeptidases that activate or inactivates protein activities. This is protein processing but not proteolysis. Most seem to play a role in immune response but due to lack of evidence, could not propagate it to the  root.
AZU1 cleaves insulin-like growth factor-binding protein-1, -2 and -4. PMID: 21550830
PG and MAF Reviewed 2014-12-10

# REFERENCE
Annotation inferences using phylogenetic trees
The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).