# HISTORY 27 Mar 2016: Updated by: TOUCHUP-v1.15 18 Nov 2015: redistribution of PTN000666829 from PTHR24259 to PTHR24256 18 Nov 2015: redistribution of PTN001208528 from PTHR24272 to PTHR24256 18 Mar 2016: Updated by: TOUCHUP-v1.14 # molecular_function 20140730: Boreoeutheria_PTN000666829 has function threonine-type endopeptidase activity (GO:0004298) # cellular_component 20150414: Euteleostomi_PTN000668442 is found in extracellular space (GO:0005615) # biological_process 20150414: Euteleostomi_PTN000668442 participates in hepatocyte growth factor receptor signaling pathway (GO:0048012) 20150414: Euteleostomi_PTN000668442 participates in positive regulation of cell proliferation (GO:0008284) 20150414: Euteleostomi_PTN000668442 participates in morphogenesis of a branching epithelium (GO:0061138) 20150414: Boreoeutheria_PTN000668522 participates in positive regulation of apoptotic process (GO:0043065) # WARNINGS - THE FOLLOWING HAVE BEEN REMOVED FOR THE REASONS NOTED ## Annotations that have been removed. 20140730: Opisthokonta_PTN001207579 to serine-type endopeptidase activity (GO:0004252) doesn't pass taxon checks # NOTES # REFERENCE Annotation inferences using phylogenetic trees The goal of the GO Reference Genome Project, described in PMID 19578431, is to provide accurate, complete and consistent GO annotations for all genes in twelve model organism genomes. To this end, GO curators are annotating evolutionary trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree by sequence similarity (ISS), and unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. The annotations are done using a tool called PAINT (Phylogenetic Annotation and INference Tool).